Natural Products and Cardiovascular Health  book cover
1st Edition

Natural Products and Cardiovascular Health

ISBN 9781498789004
Published December 13, 2018 by CRC Press
240 Pages 36 B/W Illustrations

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Book Description

This unique volume provides the latest information on secondary metabolites obtained from selected organisms (plants or microorganisms) that have beneficial effects in the treatment of cardiovascular diseases and an ability to offer protection against their progress. A detailed description of their source, chemistry and mechanism of action is provided, together with results of clinical studies. Here, a clear connection is made between chemical structures, in vitro studies and their clinical significance.The topic is extensive and the audience gains an understanding of the medicinal applications of these groups of secondary metabolites that have the potential to improve cardiovascular health.


  • The latest information on secondary metabolites with beneficial effects in the treatment of cardiovascular diseases.
  • Written by an outstanding team of authors, their work provides new insights into the beneficial effects of different components present in well known plant products, evidencing their impressive cardiovascular effects.
  • This volume discusses novel targets to screen for new drugs and the need for data obtained from clinical studies using natural products in order to better analyze the significance of in vitro experimental data.
  • Here the reader will find a unique and timely volume with an international flavor.
  • This book describes the source, chemistry and mechanism of action of natural products with the potential to improve cardiovascular health.
  • Table of Contents





    Chapter 1 Beneficial Effects of Omega-3 Fatty Acids on Cardiovascular Disease

    Estela Guerrero De León, Mahabir Prashad Gupta and Juan Antonio Morán-Pinzón

    Chapter 2 Natural Polyketides to Prevent Cardiovascular Disease: Statins

    George Hanna and Mark T. Hamann

    Chapter 3 Impact of Dietary Polyphenols on Arterial Stiffness: Outline of Contributing Mechanisms

    Tess De Bruyne, Lynn Roth, Harry Robberecht, Luc Pieters, Guido De Meyer and Nina Hermans

    Chapter 4 Potential Therapeutic Uses of the Genus Cecropia as an Antihypertensive Herbal Medicinal Product

    Mahabir Prashad Gupta, Orlando O. Ortíz, Andrés Rivera-Mondragón and Catherina Caballero-George

    Chapter 5 Berries and Lipids in Cardiovascular Health

    Arpita Basu, Nancy Betts, Paramita Basu and Timothy J. Lyons

    Chapter 6 Cardiovascular Protection Effects of Proanthocyanidins

    Graham C. Llivina, Megan M. Waguespack and Angela I. Calderón

    Chapter 7 Extra-Virgin Olive Oil and Blood Pressure: A New Approach to the Treatment of Cardiovascular Disease

    Ana Belén Segarra, Magdalena Martínez-Cañamero, Germán Domínguez-Vías, Marina Hidalgo, Manuel Ramírez‑Sánchez and Isabel Prieto

    Chapter 8 Role of Herbs and Spices in Cardiovascular Health

    Haroon Khan, Ada Popolo, Marya and Luca Rastrelli

    Chapter 9 Serum Albumin Binding of Natural Substances and Its Influence on the Biological Activity of Endogenous and Synthetic Ligands for G-Protein-Coupled Receptors

    Sarah Engelbeen and Patrick M.L. Vanderheyden


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    Dr. Caballero-George - is a research scientist at the Institute of Scientific Research and High Technology Services (INDICASAT AIP), a government research facility in the Republic of Panama. She is also head of the Laboratory of Pharmacology at this institution and the founder of the Group of Pharmaceutical Research, formed by scientists from Belgium, Germany, Spain, United States, Venezuela, Costa Rica and Panamá. She is the developer of the new Unit for Intellectual Property Management at INDICASAT AIP and active member of a national initiative to thrust Panamanian innovation at the private and government level.Dr. Caballero-George obtained her doctorate degree in Pharmaceutical Sciences at the University of Antwerp (2002) with a scholarship from the National Secretariat of Science and Technology (SENACYT) and the Panamanian Scholarship Institute (IFARHU). She was a visiting scholar at the University of Mississippi in Oxford (2005) and the University of Bönn (2008). In 2011, she received the TWAS-APANAC Young Scientist Award for her work on marine pharmacology of natural products. Her research has focused on studying the effects of natural products from plants and marine fungi on blood pressure regulation as shown in her publications. Dr. Caballero-George was a contributor and editor of a book on Intellectual Property Rights Management in Developing Countries /NAM S&T Center (2013) and more recently, she acted as guest editor of the international journal Planta Medica on the special issue dedicated to Cardiovascular Protection of Natural Products (2015).