1st Edition

Nature's Gift to Neuroscience A Tribute to Sydney Brenner and John Sulston

Edited By Chun-Fang Wu, Joy Alcedo Copyright 2022
    372 Pages
    by CRC Press

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    In the 1960s, Sydney Brenner proposed to use the nematode worm Caenorhabditis elegans to discover the control mechanisms of animal development and to reveal how a small number of neurons generate different behaviours, giving birth to a vibrant community that uses this animal model for their studies. Brenner was aided in his aim by John Sulston, who mapped the C. elegans cell lineages – from a single cell to the multicellular adult – which transformed the field of developmental biology.

    As a tribute to these two men, this book captures the perspectives of some of the early pioneers of the worm community, from Martin Chalfie, Robert Waterston and Donald Moerman to Catherine Rankin, Antony Stretton and John White. It also includes contributions from subsequent generations of the community, who explore the development and function of the C. elegans nervous system. This book features how this animal has become one of the best models for elucidating the biology of different sensory modalities and their complex behavioural outputs, or how this animal’s survival strategies have contributed to our understanding of ageing and neurodegeneration. Thus, this volume documents the development of the C. elegans neuroscience field, from infancy to maturity.

    The chapters in this book were originally published as a special issue of the Journal of Neurogenetics.

    Introduction: Nature's gift to neuroscience 
    Joy Alcedo, Yishi Jin, Douglas S. Portman, Veena Prahlad, David Raizen, Georgia Rapti, X.Z. Shawn Xu, Yun Zhang, and Chun-Fang Wu 
    Part 1: The early years of C. elegans neurogenetics 
    1. My life with Sydney, 1961–1971 
    Antony O. W. Stretton 
    2. John Sulston (1942–2018): a personal perspective 
    Robert H. Waterston and Donald G. Moerman 
    3. A touching story 
    Martin Chalfie 
    4. But can they learn? My accidental discovery of learning and memory in C. elegans 
    Catharine H. Rankin 
    5. Of worms and men 
    John White 
    Part 2: Nervous system development 
    6. A perspective on C. elegans neurodevelopment: from early visionaries to a booming neuroscience research 
    Georgia Rapti 
    7. Neuronal specification in C. elegans: combining lineage inheritance with intercellular signaling 
    Antoine Barrière and Vincent Bertrand 
    8. Molecular mechanisms governing axonal transport: a C. elegans perspective 
    Amruta Vasudevan and Sandhya P. Koushika 
    9. C. elegans MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density 
    Salvatore J. Cherra III, Alexandr Goncharov, Daniela Boassa, Mark Ellisman, and Yishi Jin 
    10. Synaptic remodeling, lessons from C. elegans 
    Andrea Cuentas-Condori and David M. Miller, 3rd 
    11. What about the males? the C. elegans sexually dimorphic nervous system and a CRISPR-based tool to study males in a hermaphroditic species 
    Jonathon D. Walsh, Olivier Boivin, and Maureen M. Barr 
    12. Cell-type-specific promoters for C. elegans glia 
    Wendy Fung, Leigh Wexler, and Maxwell G. Heiman  
    Part 3: From inputs to outputs 
    13. C. elegans: a sensible model for sensory biology 
    Adam J. Iliff and X.Z. Shawn Xu 
    14. Temperature signaling underlying thermotaxis and cold tolerance in Caenorhabditis elegans 
    Asuka Takeishi, Natsune Takagaki, and Atsushi Kuhara 
    15. Mechano-gated channels in C. elegans 
    Umar Al-Sheikh and Lijun Kang 
    16. What can a worm learn in a bacteria-rich habitat? 
    He Liu and Yun Zhang 
    17. C. elegans aversive olfactory learning generates diverse intergenerational effects 
    Ana Goncalves Pereira, Xicotencatl Gracida, Konstantinos Kagias and Yun Zhang 
    Part 4: Social and sexual behaviors 
    18. Social and sexual behaviors in C. elegans: the first fifty years 
    Douglas S. Portman 
    19. Small molecule signals mediate social behaviors in C. elegans 
    Caroline S. Muirhead and Jagan Srinivasan 
    20. Intraguild predation between Pristionchus pacificus and Caenorhabditis elegans: a complex interaction with the potential for aggressive behaviour 
    Kathleen T. Quach and Sreekanth H. Chalasani 
    21. Plasticity of pheromone-mediated avoidance behavior in C. elegans 
    YongJin Cheon, Hyeonjeong Hwang, and Kyuhyung Kim 
    Part 5: Quiescence and sleep 
    22. Worms sleep: a perspective 
    David Raizen 
    23. Cellular damage, including wounding, drives C. elegans stress-induced sleep 
    Desiree L. Goetting, Richard Mansfield, Rony Soto, and Cheryl Van Buskirk 
    24. Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans 
    Madison Honer, Kristen Buscemi, Natalie Barrett, Niknaz Riazati, Gerald Orlando, and Matthew D. Nelson 
    25. Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics 
    Kelsey N. Schuch, Lakshmi Narasimhan Govindarajan, Yuliang Guo, Saba N. Baskoylu, Sarah Kim, Benjamin Kimia, Thomas Serre, and Anne C. Hart 
    26. The OptoGenBox – a device for long-term optogenetics in C. elegans 
    Inka Busack, Florian Jordan, Peleg Sapir, and Henrik Bringmann 
    Part 6: Survival, aging and disease 
    27. Neuromodulators: an essential part of survival 
    Joy Alcedo and Veena Prahlad 
    28. Neuroendocrine control of lipid metabolism: lessons from C. elegans 
    Supriya Srinivasan 
    29. The discovery and consequences of the central role of the nervous system in the control of protein homeostasis 
    Veena Prahlad 
    30. Host-microbe interactions and the behavior of Caenorhabditis elegans 
    Dennis H. Kim and Steven W. Flavell 
    31. Neurogenetics of nictation, a dispersal strategy in nematodes 
    Heeseung Yang, Bo Yun Lee, Hyunsoo Yim, and Junho Lee 
    32. Regulatory systems that mediate the effects of temperature on the lifespan of Caenorhabditis elegans 
    Byounghun Kim, Jongsun Lee, Younghun Kim, and Seung-Jae V. Lee 
    33. The contribution of C. elegans neurogenetics to understanding neurodegenerative diseases 
    Joseph J. H. Liang, Issa A. McKinnon, and Catharine H. Rankin 
    Part 7: Worm photo and art gallery 
    34. A journey to ‘tame a small metazoan organism’, seen through the artistic eyes of C. elegans researchers 
    Eleni Gourgou, Alexandra R. Willis, Sebastian Giunti, Maria J. De Rosa, Amanda G. Charlesworth, Mirella Hernandez Lima, Elizabeth Glater, Sonja Soo, Bianca Pereira, Kübra Akbas, Anushka Deb, Madhushree Kamak, Mark W. Moyle, Annika Traa, Aakanksha Singhvi, Surojit Sural, and Eugene Jennifer Jin 


    Chun-Fang Wu is Editor-in-Chief of the Journal of Neurogenetics. He has conducted neurobiological research in Drosophila, applying genetic, cell biological, physiological, and behavioural techniques in the studies.

    Joy Alcedo is Guest Editor for the C. elegans special issue of the Journal of Neurogenetics. Her research focuses on the sensory and neuromodulatory influences on C. elegans development and survival programs.