Nature's Gift to Neuroscience : A Tribute to Sydney Brenner and John Sulston book cover
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Nature's Gift to Neuroscience
A Tribute to Sydney Brenner and John Sulston



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ISBN 9781032145211
February 28, 2022 Forthcoming by CRC Press
352 Pages

 
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Book Description

In the 1960s, Sydney Brenner proposed to use the nematode worm Caenorhabditis elegans to discover the control mechanisms of animal development and to reveal how a small number of neurons generate different behaviours, giving birth to a vibrant community, which uses this animal model for their studies. Brenner was aided in his aim by John Sulston, who mapped the C. elegans cell lineages – from a single cell to the multicellular adult – which transformed the field of developmental biology.

As a tribute to these two men, this book captures the perspectives of some of the early pioneers of the worm community, from Martin Chalfie, Robert Waterston and Donald Moerman to Catherine Rankin, Antony Stretton and John White. It also includes contributions from subsequent generations of the community, who explore the development and function of the C. elegans nervous system. This book features how this animal has become one of the best models for elucidating the biology of different sensory modalities and their complex behavioural outputs or how this animal’s survival strategies have contributed to our understanding of aging and neurodegeneration. Thus, this volume documents the development of the C. elegans neuroscience field, from infancy to maturity.

The chapters in this book were originally published as a special issue of the Journal of Neurogenetics.

Table of Contents

Introduction

Joy Alcedo, Yishi Jin, Douglas S. Portman, Veena Prahlad, David Raizen, Georgia Rapti, X.Z. Shawn Xu, Yun Zhang, and Chun-Fang Wu

The early years of C. elegans neurogenetics

1. My life with Sydney, 1961–1971

Antony O. W. Stretton

2. John Sulston (1942–2018): a personal perspective

Robert H. Waterston and Donald G. Moerman

3. A touching story

Martin Chalfie

4. But can they learn? My accidental discovery of learning and memory in C. elegans

Catharine H. Rankin

5. Of worms and men

John White

Nervous system development

6. A perspective on C. elegans neurodevelopment: from early visionaries to a booming neuroscience research

Georgia Rapti

7. Neuronal specification in C. elegans: combining lineage inheritance with intercellular signaling

Antoine Barrière and Vincent Bertrand

8. Molecular mechanisms governing axonal transport: a C. elegans perspective

Amruta Vasudevan and Sandhya P. Koushika

9. C. elegans MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density

J. Cherra III, Alexandr Goncharov, Daniela Boassa, Mark Ellisman, and Yishi Jin

10. Synaptic remodeling, lessons from C. elegans

Andrea Cuentas-Condori and David M. Miller, 3rd

11. What about the males? the C. elegans sexually dimorphic nervous system and a CRISPR-based tool to study males in a hermaphroditic species

Jonathon D. Walsh, Olivier Boivin, and Maureen M. Barr

12. Cell-type-specific promoters for C. elegans glia

Wendy Fung, Leigh Wexler, and Maxwell G. Heiman

From inputs to outputs

13. C. elegans: a sensible model for sensory biology

Adam J. Iliff and X.Z. Shawn Xu

14. Temperature signaling underlying thermotaxis and cold tolerance in Caenorhabditis elegans

Asuka Takeishi, Natsune Takagaki, and Atsushi Kuhara

15. Mechano-gated channels in C. elegans

Umar Al-Sheikh and Lijun Kang

16. What can a worm learn in a bacteria-rich habitat?

He Liu and Yun Zhang

17. C. elegans aversive olfactory learning generates diverse intergenerational effects

Ana Goncalves Pereira, Xicotencatl Gracida, Konstantinos Kagias, and Yun Zhang

Social and sexual behaviors

18. Social and sexual behaviors in C. elegans: the first fifty years

Douglas S. Portman

19. Small molecule signals mediate social behaviors in C. elegans

Caroline S. Muirhead and Jagan Srinivasan

20. Intraguild predation between Pristionchus pacificus and Caenorhabditis elegans: a complex interaction with the potential for aggressive behaviour

Kathleen T. Quach and Sreekanth H. Chalasani

21. Plasticity of pheromone-mediated avoidance behavior in C. elegans

YongJin Cheon, Hyeonjeong Hwang, and Kyuhyung Kim

Quiescence and sleep

22. Worms sleep: a perspective

David Raizen

23. Cellular damage, including wounding, drives C. elegans stress-induced sleep

Desiree L. Goetting, Richard Mansfield, Rony Soto, and Cheryl Van Buskirk

24. Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans

Madison Honer, Kristen Buscemi, Natalie Barrett, Niknaz Riazati, Gerald Orlando, and Matthew D. Nelson

25. Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics

Kelsey N. Schuch, Lakshmi Narasimhan Govindarajan, Yuliang Guo, Saba N. Baskoylu, Sarah Kim, Benjamin Kimia, Thomas Serre, and Anne C. Hart

26. The OptoGenBox – a device for long-term optogenetics in C. elegans

Inka Busack, Florian Jordan, Peleg Sapir, and Henrik Bringmann

Survival, aging and disease

27. Neuromodulators: an essential part of survival

Joy Alcedo and Veena Prahlad

28. Neuroendocrine control of lipid metabolism: lessons from C. elegans

Supriya Srinivasan

29. The discovery and consequences of the central role of the nervous system in the control of protein homeostasis

Veena Prahlad

30. Host-microbe interactions and the behavior of Caenorhabditis elegans

Dennis H. Kim and Steven W. Flavell

31. Neurogenetics of nictation, a dispersal strategy in nematodes

Heeseung Yang, Bo Yun Lee, Hyunsoo Yim, and Junho Lee

32. Regulatory systems that mediate the effects of temperature on the lifespan of Caenorhabditis elegans

Byounghun Kim, Jongsun Lee, Younghun Kim, and Seung-Jae V. Lee

33. The contribution of C. elegans neurogenetics to understanding neurodegenerative diseases

Joseph J. H. Liang, Issa A. McKinnon, and Catharine H. Rankin

34. A journey to ‘tame a small metazoan organism’, seen through the artistic eyes of C. elegans researchers

Eleni Gourgou, Alexandra R. Willis, Sebastian Giunti, Maria J. De Rosa, Amanda G. Charlesworth, Mirella Hernandez Lima, Elizabeth Glater, Sonja Soo, Bianca Pereira, Kübra Akbas, Anushka Deb, Madhushree Kamak, Mark W. Moyle, Annika Traa, Aakanksha Singhvi, Surojit Sural, and Eugene Jennifer Jin

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Editor(s)

Biography

Chun-Fang Wu is Editor-in-Chief of the Journal of Neurogenetics. He has conducted neurobiological research in Drosophila, applying genetic, cell biological, physiological, and behavioural techniques in the studies.

Joy Alcedo is Guest Editor for the C. elegans special issue of the Journal of Neurogenetics. Her research focuses on the sensory and neuromodulatory influences on C. elegans development and survival programs.