This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. The book intends to elaborate functional outcomes of component-to-component relationships using rodent and nonhuman primate in vitro and in vivo models that allow for the directional and quantitative description of the complete organism in response to environmental perturbations. In addition, attention has also been directed to some of the more recent methodologies, including genomics, proteomics and metabolomics, applied in the evolutionary neurobiological field.
Table of Contents
Neurons -- Nerve Cells
Fang Liu, Tucker A. Patterson, Jingshu Zhang, Merle G. Paule, William Slikker, Jr. and Cheng Wang
Cheng Wang, Qi Yin, Shuliang Liu, Xuan Zhang, Fang Liu, Jingshu Zhang, Tucker A. Patterson, Merle G. Paule and William Slikker, Jr.
Oligodendrocytes [myelin-related glial cell in the central nervous system (CNS)]
Shuliang Liu, Merle G. Paule, Fang Liu, Qi Yin, Tucker A. Patterson, William Slikker, Jr. and Cheng Wang
Xuan Zhang, Tucker A. Patterson, Merle G. Paule, Cheng Wang and William Slikker, Jr.
Zhen He, Sherry A. Ferguson, Tucker A. Patterson and Merle G. Paule
Neural Stem Cells in the Adult Brain: Altered Activity in Aging, Alzheimer’s Disease, Mood Disorders and Epilepsy
Ashok K. Shetty and Bharathi Hattiangady
Neural Stem Cells and Transplantation
3D in vitro Models for Developmental Neurotoxicity (DNT)
Luc Stoppini, Jenny Sandström von Tobel, Igor Charvet, Marie-Gabrielle Zurich, Lars Sundstrom and Florianne Monnet-Tschudi
Neural Cell Lines (Lineage)
Advanced Cell Techniques to Study Developmental Neurobiology and Toxicology
Thomas Hartung, Helena T. Hogberg, Marcel Leist, David Pamies and Lena Smirnova
Anesthesia and Neural Plasticity
Blood-Brain Barrier (BBB)
Balabhaskar Prabhakarpandian, Syed Ali and Kapil Pant
Neurotrophins and Alzheimer’s Disease
Neurotransmitters and Receptors
15. Neuronal Ion Channels
Slobodan M. Todorovic
16. Brain Injury - Neuroprotection
Koichi Yuki, Mary Ellen McCann and Sulpicio G. Soriano
Cheng Wang, Ph.D, is a senior scientist at the National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. He also is an adjunct faculty member of the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences (UAMS), Little Rock, USA.
Dr. William Slikker is a recognized expert in neurotoxicology and the director of the National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas.