A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration was held at Araraquara, São Paulo, Brazil in 2011. This meeting was convened as an official satellite of a joint gathering of the International Society for Autonomic Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, Rio de Janeiro. Broad international participation at this event generated stimulating discussion among the invited speakers, leading to the publication of Neurobiology of Body Fluid Homeostasis: Transduction and Integration.
Drawn from the proceedings and filled with rich examples of integrative neurobiology and regulatory physiology, this volume:
- Provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite
- Explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior
- Discusses recent developments in molecular genetics, cell biology, and behavioral plasticity
- Reviews key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure
The book highlights research conducted by leading scientists on signal transduction and sensory afferent mechanisms, molecular genetics, perinatal and adult long-term influences on regulation, central neural integrative circuitry, and autonomic/neuroendocrine effector systems. The findings discussed by the learned contributors are relevant for a basic understanding of disorders such as heat injury, hypertension, and excess salt intake. A unique reference on the neurobiology of body fluid homeostasis, this volume is certain to fuel additional research and stimulate further debate on the topic.
Table of Contents
The Human Penchant for Deranged Salt Balance. Circumventricular Organs: Integrators of Circulating Signals Controlling Hydration, Energy Balance, and Immune Function. Neuroendocrinology of Hydromineral Homeostasis. Preoptic–Periventricular Integrative Mechanisms Involved in Behavior, Fluid–Electrolyte Balance, and Pressor Responses. Diverse Roles of Angiotensin Receptor Intracellular Signaling Pathways in the Control of Water and Salt Intake. Separating Thirst from Hunger. Interdependent Preoptic Osmoregulatory and Thermoregulatory Mechanisms Influencing Body Fluid Balance and Heat Defense. Catecholaminergic Medullary Pathways and Cardiovascular Responses to Expanded Circulating Volume and Increased Osmolarity. Neurochemical Circuits Subserving Fluid Balance and Baroreflex: A Role for Serotonin, Oxytocin, and Gonadal Steroids. Brain Serotonergic Receptors and Control of Fluid Intake and Cardiovascular Function in Rats. Serotonergic Autoinhibition within Dorsal Raphe Nucleus Modulates Sodium Appetite. A Classic Innate Behavior, Sodium Appetite, Is Driven by Hypothalamic Gene-Regulatory Programs Previously Linked to Addiction and Reward. Development of Local RAS in Cardiovascular/Body Fluid Regulatory Systems and Hypertension in Fetal Origins. Sodium Appetite Sensitization. Homeostasis and Body Fluid Regulation: An End Note. Index.
Laurival Antonio De Luca, José Vanderlei Menani, Alan Kim Johnson