Neuronal Cytoskeleton: Morphogenesis, Transport, and Synaptic Transmission, 1st Edition (Hardback) book cover

Neuronal Cytoskeleton

Morphogenesis, Transport, and Synaptic Transmission, 1st Edition

By Hirokawa

CRC Press

300 pages

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Hardback: 9780849377419
pub: 1994-01-12
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This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.

Table of Contents

Overview: The Neuronal Cytoskeleton: Roles in Neuronal Morphogenesis and Organelle Transport, N. Hirokawa

Molecular Genetics of Kinesin Motors, L.S.B. Goldstein

Characterization of Human Kinesin Heavy Chain Genes, R. Vale, F. Navone, J. Niclas, and N. Hom-Booher

The Molecular Basis of Fast Axonal Transport, G.S. Bloom

Regulation of Organella Transport by Phosphorylation of Kinesin and by Decoration of Microtubules with Microtubule-Associated Proteins, R. Sato-Yoshitake, Y. Okada, S. Okabe, T. Umeyama, and N. Hirokawa

Axonal Homeostasis and the Nature of Regulated Retrograde Organelle Transport, P.J. Hollenbeck and R.S. Weld

Kinectin: A Kinesin Receptor on Endoplasmic Reticulum, I. Toyoshima and M.P. Sheetz

Neurogenesis and Cytoskeleton: Expression of the Nestin Intermediate Filament in Neurepithelial Stem Cells, L.B. Zimmerman and R.D.G. McKay

Molecular and Developmental Studies of Neuronal Intermediate Filaments, G.Y. Ching, M.P. Kaplan, and R.K.H. Liem

Gelsolin is Involved in Myelin Formation, J. Tanaka and K. Sobue

Dynamics of the Neuronal Cytoskeleton, S. Okabe and N. Hirokawa

Sites of Microtubule Assembly in Growing, M.M. Black and A. Brown

Regulation of Tubulin Organization in the Axon, T. Tashiro

Steroid Hormone Effect of Neuronal Configuration-In Vivo and In Vitro Studies, M. Kawata, K. Yuri, N. Morita, and M. Morimoto

Microtubule Bundling by Tau Proteins In Vivo, Y. Kanai and N. Hirokawa

Nuclear Tau Proteins: Implications in Alzheimer's Disease and Down Syndrome, R.P. Zinkowski, R.E. Powers, P.A. Loomis, Y. Wang, and L.I. Binder

Tau Proteins and Alzheimer's Disease, M. Goedert

Abnormal Phosphorylation of Tau in the Alzheimer's Disease Brain, M. Hasegawa, M. Morishima, K. Takio, M. Suzuki, A. Watanabe, T. Arai, K. Titani, and Y. Ihara

Ca2+-Dependent Regulation of the Neuronal Cytoskeleton, K. Sobue

Annexin VI-Binding Proteins in Brain, M. Inui, T. Watanabe, M. Iga, B.-Y. Chen, and K. Sobue

Is Dynamin GTPase a Microtubule Associated Motor?, T. Nakata, Y. Noda, K. Maeda, R. Sato-Yoshitake, Y. Okada, R. Takemura, and N. Hirokawa

Compartmentation of p60c-src Complex in Developing Rat Forebrain Membrane, K. Ozawa, S. Tadokoro, M. Kira, M. Takahashi, O. Takeuchi, and K. Sobue

Identifying Novel Synapse Associated Proteins, C.C. Garner, A. Garner, B. Vob, U. Appeltauer, and E.D. Gundelfinger)

Subject Index

Author Index

Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / Neuroscience