1st Edition

Neurotransmitter Receptors in Actions of Antipsychotic Medications

Edited By Michael S. Lidow Copyright 2000

    Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs - drugs that pose a lower risk of developing tardive dyskinesia, have few

    Schizophrenic Syndromes. General Overview of Antipsychotic Medications. Effects of Antipsychotic Drugs on Dopamine Release and Metabolism in the Central Nervous System. Antipsychotic Drugs, Dopamine D2, and Schizophrenia. D1 Dopamine Receptors, Schizophrenia, and Antipsychotic Medications. Serotonin Receptors as Targets of Antipsychotic Medications. Role of Adrenergic Receptors in Effects of Antipsychotic Medications on Prefrontal Cortical Function. Glutamate Receptors in Schizophrenia and Antipsychotic Drugs. Antipsychotic Effects of Sigma Drugs. GABA-ergic Drugs in Schizophrenia. Receptor Occupancy by Antipsychotics - Concepts and Findings. Regulation of Neurotransmitter Receptors by Antipsychotic Medications. Modulation of Cellular Signaling Pathways by Antipsychotic Medications. The Role of Neurotransmitter Receptors in the Adverse Effects of Antipsychotic Drugs. Future Perspectives of Antipsychotic Drug Development.

    Biography

    Michael S. Lidow