New and Exploratory Therapeutic Agents for Asthma: 1st Edition (Hardback) book cover

New and Exploratory Therapeutic Agents for Asthma

1st Edition

By Michael Yeadon, Zuzana Diamant

CRC Press

528 pages

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Hardback: 9780824778613
pub: 1999-11-12
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Description

Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics-as well as potential new therapeutic approaches!

This comprehensive volume addresses the latest treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies.

Presents the most up-to-date information available on the genetics, epidemiology, pathology, pharmacology, and pulmonology of asthma.

Written by more than 20 leading international experts, New and Exploratory Therapeutic Agents for Asthma

  • explores asthma both as incidence of dysfunctional airway smooth muscle and as a disorder of the immune system

  • examines the role of monoclonal antibodies in allergy and asthma

  • describes functions and pharmacokinetic profiles of bronchodilator 2 agonists, anticholinergics, and inhaled glucocorticosteroids

  • investigates the controversy of different types of asthma

  • illustrates the connections between clinical symptoms and the immunopathology of eosinophilic inflammation

  • assesses prospects for the development of a successful oral anti-inflammatory therapy, an immunomodulator that lowers antigen-specific IgE, an anticytokine compound, and an agent that safely combines bronchospasmolytic and anti-inflammatory properties

  • reviews the impact of the recent introduction of antileukotriene agents, clinical findings with PAF antagonists, and selective antimuscarinics

  • evaluates the relationship between improvements in laboratory results and clinical effectiveness

  • and more!

    Containing over 2000 bibliographic citations and a concise introduction for each chapter, New and Exploratory Therapeutic Agents for Asthma is indispensable for pulmonologists, pediatricians, physiologists, immunologists, allergists, pharmaceutical industry scientists, primary care physicians, and medical school students in these disciplines.

  • Reviews

    "

    …well-written and thoroughly referenced….provides up-to-date, easy-to-read, and high-quality coverage of new developments in asthma pharmacotherapies….highly recommend[ed].

    "-Respiratory Care

    Table of Contents

    Epidemiology of Asthma

    Stephen T. Holgate and A. N. Banik

    Pathophysiology of Asthma

    Peter J. Sterk

    Pathology of Asthma

    Ratko Djukanoviâ

    Muscarinic Receptor Subtypes and Anticholinergic Therapy

    Allison D. Fryer, Richard W. Costello, and David B. Jacoby

    Long-Acting 2-Agonist Drugs

    Richard Beasley, Julian Crane, and Carl Burgess

    Inhaled Glucocorticoids, Established and New

    Joseph D. Spahn and Stanley J. Szefler

    Platelet-Activating Factor Antagonists in Bronchial Asthma

    Devendra K. Agrawal and Robert G. Townley

    Tachykinin Receptor Antagonists

    Guy F. Joos and Charles Advenier

    Therapeutic Potential of Phosphodiesterase Type 4 Inhibitors in the Treatment of Asthma

    Bernadette Hughes and Gerry Higgs

    Leukotriene Modulators

    Anthony P. Sampson and Zuzana Diamant

    The Anti-IgE Treatment Strategy for Asthma

    John V. Fahy

    Activity of T-Cell Subsets in Allergic Asthma

    André Boonstra and Huub F. J. Savelkoul

    New Targets for Future Asthma Therapy

    Peter J. Barnes

    Current Practice and Future Trends in Clinical Trials in Asthma

    Johan C. Kips and Romain A. Pauwels

    Subject Categories

    BISAC Subject Codes/Headings:
    MED000000
    MEDICAL / General
    MED079000
    MEDICAL / Pulmonary & Thoracic Medicine