This publication serves as a guide to medical doctors and dentists in the evaluation and management of problems related to nickel allergy. The chemistry, analysis, and monitoring of nickel is explored. Recent advances in the immunology of nickel are dis-cussed. Additionally, sensitization assays for both humans and animals are presented. The clinical, genetic, and epidemiologic as-pects of nickel sensitization and nickel dermatitis are explained. Social and demographic aspects of nickel contact allergy are dis-cussed, as well as the topic of the nickel dermatitis as a pre-ventable health problem.
Chemistry, Analysis, and Monitoring. Human Nickel Exposure and Chemobiokinetics. Carcinogenicity. Nickel Al-loys and Coatings: Release of Nickel. Recent Advances in Im-munology of Nickel. Nickel: Animal Sensitization Assays. Nickel: Human Sensitization Assays. In Vitro Testing in Nickel Con-tact Hypersensitivity. Clinical Concepts in Nickel Testing. Genetic Aspects of Nickel Sensitization. Epidemiology of Nickel Dermatitis. Occupational Nickel Dermatitis. Nickel Allergy and Hand Eczema. Nickel Dermatitis: Its Relationship to Food and Experimental Oral Challenge. Nickel Allergy and Drug Interaction. Nickel Allergy and Orthopedic Prostheses. Nickel Allergy and Dental Treatment Pro-cedures. Social and Demographic Aspects of Nickel Contact Al-lergy. Nickel Dermatitis: A Preventable Health Problem. Index.