Noninvasive Molecular Markers in Gynecologic Cancers: 1st Edition (Hardback) book cover

Noninvasive Molecular Markers in Gynecologic Cancers

1st Edition

Edited by Debmalya Barh, Mehmet Gunduz

CRC Press

516 pages | 32 Color Illus. | 44 B/W Illus.

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Hardback: 9781466569386
pub: 2015-01-22
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Early detection is critical for any given cancer. With the advent of the latest omics technologies, molecular markers in combination with conventional diagnostic and screening methods are emerging as next-generation early diagnostic and prognostic strategies that can allow early-stage diagnosis, resulting in more effective treatment and patient care and, in turn, an increased rate of survival. A ready-made resource, Noninvasive Molecular Markers in Gynecologic Cancers not only provides information on noninvasive molecular diagnostic biomarkers, it includes coverage of the epidemiology, clinical features, conventional diagnosis, treatment, and prognosis for these cancers.

With contributions from leading international experts, the book presents a compact but comprehensive overview of gynecologic cancer. Each of the five main gynecologic cancers—ovarian, cervical, uterine, vaginal, and vulvar—have unique signs and symptoms, risk factors, and molecular profile, and therefore requires different prevention strategies. This book describes the different features of each gynecologic cancer in separate chapters covering general information, epidemiology, clinical features, and biomarkers. The book also covers breast cancer and, although rare, fallopian tube cancer, to make it a complete resource.

In cancer treatment, non-invasive diagnosis can avoid complications of biopsy and other unfavorable impacts on patients’ health. DNA, methylation, SNPs, miRNA, mRNA, protein, autoantibodies, metabolite, and omics-based markers from remote media such as blood, plasma, and urine are emerging as noninvasive molecular markers with high specificity and sensitivity towards many cancers. This book classifies the available molecular tumor markers according to their principal characteristics and relative methodologies. It covers markers that not only provide early detection and better treatment options, but are emerging as next-generation personalized diagnostics and targets or therapeutics for personalized cancer treatment.

Table of Contents


Overview of Gynecologic Cancers

Ikbal Kaygusuz, Aydin Kosus, and Hasan Kafali

Cytogenetic Early Markers in Gynecologic Cancers

Murat Oznur, Serap Dede, Debmalya Barh, and Mehmet Gunduz


Early Biomarkers in Breast Cancer

Ruchika Kaul-Ghanekar, Snehal Suryavanshi, and Prerna Raina

Diagnostic and Prognostic Markers of Breast Invasive Lesions

Maria C. Calomarde, Carlos Iglesias, Elisa Moreno-Palacios, Javier De Santiago, and Ignacio Zapardiel

Biomarkers for Early Detection of Familial Breast Cancer

Burak Yilmaz, Catherine A. Moroski-Erkul, Omer Faruk Hatipoglu, Esra Gunduz, Debmalya Barh, and Mehmet Gunduz

DNA Methylation: An Epigenetic Marker of Breast Cancer Influenced by Nutrients Acting as an Environmental Factor

Tarique N. Hasan, Gowhar Shafi, B. Leena Grace, Jesper Tegner, and Anjana Munshi


Biomarkers for Early Detection of Cervical Cancer

Ruchika Kaul-Ghanekar, Amit S. Choudhari, and Savita Pandita

Biomarkers in Cervical Cancer: DNA HR-HPV, p16INK4a, Ki-67, and RNA-m E6/E

María Serrano, María-Dolores Diestro, Marcos Cuerva, Ignacio Zapardiel, Adolfo Loayza, Alicia Hernan, and Javier De Santiago

Biomarkers of Nucleotide Metabolism in Cervical Cancer

Charles A. Kunos, Lauren Shunkwiler, and Gina Ferris


Noninvasive Early Biomarkers in Ovarian Cancer

Sharon A. O’Toole, Eugen Ancuta, Ream Langhe, Dolores J. Cahill, Mairead Murphy, Cara Martin, Lynda McEvoy, Cathy Spillane, Orla Sheils, Emmanuel Petricoin, Lance Liotta, and John J. O'Leary

Biomarkers in Ovarian Endometrioid Carcinoma

Murat Oznur, Serap Memik, Mehmet Gunduz, and Esra Gunduz

MUC16/CA125: A Candidate Tumor Marker for Diagnosis and Therapy in Ovarian Cancer

Houda Bouanene and Jemni Ben Chibani

Role of He4 in the Management of Ovarian Cancer

Daniel Abehsera, Javier De Santiago, and Ignacio Zapardiel


Biomarkers in Endometrial Cancer

Gokhan Nas, Tugce Yasar, Mehmet Gunduz, and Esra Gunduz

Biomarkers in Uterine Mesenchymal and Mixed Malignant Tumors

Rosario Rivera Buery and Esra Gunduz

Noninvasive Early Biomarkers in Fallopian Tube Carcinoma

Panagiotis Peitsidis


Biomarkers for Early Detection of Vaginal Cancers

Zeynep Ocak, Muradiye Acar, Mehmet Gunduz, and Esra Gunduz

Noninvasive Early Biomarkers for Vulvar Cancer

Sara Iacoponi, Marcos Cuerva, Mar Gil, Elisa Moreno-Palacios, Alicia Hernan, Javier De Santiago, and Ignacio Zapardiel

About the Originator


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
MEDICAL / Clinical Medicine
MEDICAL / Pharmacology