1st Edition
Novel Drug Delivery Systems for Phytoconstituents
Novel Drug Delivery Systems for Phytoconstituents discusses general principles of drug targeting, construction material and technological concerns of different phytoconstituent in delivery systems. It focuses on the development of novel herbal formulations and summarizes their method of preparation, type of active ingredients, route of administration, biological activity and their applications. It dicusses therapeutic activities of plant derived chemicals, their limitations in clinical applications and novel drug delivery solutions to overcome them to provide better therapeutic effects with controlled and targeted drug delivery.
- Focus on drug delivery of phytomolecules
- Act as bridge between natural product scientist and clinical doctors
- Discusses mechanism of poor bioavailability of herbal molecules
- Increases awareness towards phytochemical efficacy
- Summarizes efficient novel delivery systems-based formulations.
It extensively covers the applications of novel drug delivery systems including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid capsules, liposomes, phytosomes, microsphere, transferosomes, and ethosomes. Some chapters are especially focused on anticancer phytodrugs, silymarin, andrographolide, berberine, and curcumin delivery with special emphasis on their application.
Contents
Preface ..................................................................................................................................................... vii
Editors ....................................................................................................................................................... ix
Contributors .............................................................................................................................................. xi
Section I Drug Delivery Systems
1. Novel Drug Delivery Systems for Phytoconstituents: Current and Future Prospects .............. 3
Vikas Sharma, Madhu Gupta, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,
Ramesh K.Goyal, and Kamal Shah
2. Nanocarriers Systems and Their Application for the Delivery of Different
Phytoconstituents ........................................................................................................................... 9
Ebru Altuntaş, Gülgün Yener, and Burcu Özkan
3. Liposome-Based Nanocarrier System for Phytoconstituents .................................................... 45
Ngoc Thuy Trang Le, Linh Phuong Tran Pham, Diem Huong Tran Nguyen, Ngoc Hoang Le,
Tuong Vi Tran, Cuu Khoa Nguyen, and Dai Hai Nguyen
4. Phytosomes as Novel Carriers of Herbal Extracts ...................................................................... 69
Sevgi Güngör, Özlem Akbal-Dağıstan, Evren Algın Yapar, Murat Kartal, and Yıldız Özsoy
5. Lipid-Based Nanoparticles: SLN, NLC, and MAD .................................................................... 81
Rita Cortesi, Paolo Mariani, Markus Drechsler, and Elisabetta Esposito
Section II Application of Phytodrug Delivery
6. Phytosomes as Useful Drug Delivery Systems for Cosmeceutical Application ...................... 105
Francesca Froiio, Agnese Gagliardi, Massimo Fresta, Donato Cosco, and Donatella Paolino
7. Novel UV Filtering Agents for Next-Generation Cosmetics: From Phytochemicals to
Inorganic Nanomaterials ..............................................................................................................121
Aditya Arya and Jayanti Jha
8. Development of Ethosome Formulation for Topical Therapeutic Applications ..................... 137
Mansoureh Nazari Vishkaei, Mohamed B. Khadeer Ahamed, and Amin Malik Shah
Abdul Majid
9. Application of Phytodrug Delivery in Anticancer Therapy ..................................................... 157
Xiuhua Wang and Shirui Mao
Section III Phytomolecule Drug Delivery
10. Improved Silymarin Characteristics for Clinical Applications by Novel Drug
Delivery Systems ........................................................................................................................... 195
Maryam Tabarzad, Fatemeh Ghorbani-Bidkorbeh, and Tahereh Hosseinabadi
11. Silymarin—A Scintillating Phytoantioxidant: Clinical Applications and Bio-delivery
Problems ........................................................................................................................................ 223
Aditya Arya, Subhojit Paul, and Anamika Gangwar
12. Innovative Delivery Systems for Andrographolide Delivery ................................................... 241
A. C. Santos, J. A. D. Sequeira, F. Veiga, A. Figueiras, and A. J. Ribeiro
13. Polymeric Colloidal Carriers for Natural Polyphenolic Compounds ......................................261
Maria Rosaria Lauro, Teresa Musumeci, Francesca Sansone, Giovanni Puglisi, and
Rosario Pignatello
14. Drug Delivery Systems for the Controlled Delivery of Berberine ........................................... 283
Rosario Pignatello, Simona Cianciolo, and Agata K. Giuffrida
15. Lipid-Based Nanoformulations from Plants for Sustainable Drug Delivery ......................... 301
Ilaria Clemente, Ilaria Colzi, and Sara Falsini
16. Nanotechnological-Based Drug Delivery System for Magical Molecule Curcumin:
Delivery, Possibilities and Challenges .........................................................................................313
Madhu Gupta, Vikas Sharma, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,
Kamal Shah, and Ramesh K. Goyal
Index .......................................................................................................................................................333
Biography
Editors
Madhu Gupta has research experience pertaining to drug delivery
to nanoformulations for magical molecule delivery, bioligands for
targeting of bioactives and drug moiety, biopolymers, cancer nanomedicine,
as well as topical delivery that is carried out at the
Department of Pharmaceutical Sciences, Dr. H.S. Gour Central
University, Sagar. Dr. Gupta has done her B. Pharm (Gold Medalist),
M. Pharm, PhD in Pharmaceutics with experience of more than
12 years in academics, administrative functions, and research in
areas of pharmaceutical nanotechnology and targeted drug delivery
related to cancer, fungal infection, and psoriasis.
Presently she is working as an officer on special duty to Vice-
Chancellor in Delhi Pharmaceutical Sciences and Research
University. Along with teaching and research, she is Chief Operating
Officer of World Class Skill Centre courses, PRO, website In-charge,
IQAC in addition to much other managerial work.
She is pioneer scientist in the fields of nanotechnology and drug delivery. She has judiciously exploited
bioligands for targeting of bioactives and drug moiety. She has over 40 research publications to her
credit published in journals of high scientific impact and contributed 18 chapters in various renowned
books and to several international and national books. Dr. Gupta has H-index of 12, i10-index of 14, and
more than 600 citations. She has been awarded by various national and international conferences in the
form of best oral and poster presentation award and other national and international awards. She has
supervised 15 MPharm students. Dr. Gupta has availed several prestigious fellowships and awards
SRF AICTE (NDF), JRF (AICTE), Travel grant awards (DST, ICMR, INSA, and DBT, MPCST), Prof.
G.P. Nair Award (2004), and Prof. C.S. Chauhan Award (2004). She has her research work at BioAsia
Innovation Award—2012, Grace India Awards, Youth Education Award 2018, and Young Researcher
Award. She has successfully completed one project that is funded by MPCST Bhopal.
She is the nominee of CPCSEA and also an active member of various pharmaceutical bodies such
as APTI and others. She is a reviewer of various journals of repute. She has attended various conferences/
seminars/workshops/FDPs as organizer/coordinator/resource person/participant. Dr. Gupta and
her team have been selected for funding of one start-up.
Durgesh Nandini Chauhan completed her BPharm degree in
Pharmacy from the Rajiv Gandhi Proudyogiki Vishwavidyalaya,
Bhopal, India, and her MPharma (pharmaceutical sciences) in pharmaceutics
from Uttar Pradesh Technical University, currently Dr. A.P.J.
Abdul Kalam Technical University, Lucknow, in 2006. Mrs. Durgesh
Nandini Chauhan has 10 years of academic (teaching) experience from
Institutes of India in pharmaceutical sciences. She taught such subjects
as pharmaceutics, pharmacognosy, traditional concepts of medicinal
plants, drug-delivery phytochemistry, cosmetic technology, pharmaceutical
engineering, pharmaceutical packaging, quality assurance,
dosage form designing, and anatomy and physiology.
She is member of the Association of Pharmaceutical Teachers
of India, SILAE: Società Italo-Latinoamericana di Etnomedicina
(The Scientific Network on Ethnomedicine, Italy), and so forth. Her
previous research work includes Penetration Enhancement Studies on Organogel of Oxytetracycline
HCL. She also attended AICTE-sponsored Staff Development Program on “Effects of Teaching and
Learning Skills in Pharmacy-Tool for Improvement of Young Pharmacy Teachers” and workshop on
Analytical Instruments. She has written more than 10 publications in national and international journals,
13 book chapters, and authored 2 books: Optimization and Evaluation of an Organogel and Plant and
Marine Based Phytochemicals for Human Health: Attributes, Potential, and Use. She is also active
as a reviewer for several international scientific journals and active participant in national and international
conferences such as Bhartiya Vigyan Sammelan and International Convention of Society of
Pharmacognosy. Presently she is part of the Ishita Research Organization, Raipur, India, as a freelance
writer and guiding pharmacy, Ayurvedic, and science students in their research projects.
Vikas Sharma is Associate Professor and Principal Shri Rawatpura
Sarkar Institute of Pharmacy Datia, India. Dr. Sharma obtained his
BPharm from Jiwaji University Gwalior, MPharm in Pharmacognosy,
and PhD from Dr. H.S. Gour Central University Sagar, India.
Dr. Sharma has more than 12 years of teaching and research experience.
He has made significant contributions in the area of medicinal
plant research. He has been working on evidence-based validation of
medicinal plants and pharmacological screening of herbal drugs. Dr.
Sharma works on marker and biomarker analysis of herbs for quality
evaluation. He has also made significant contributions to development
of chemical profiling of extracts and formulation through TLC,
HPTLC, and LC-MS. He is supervising scientific research of the postgraduation
and the doctoral level. He has written several researches and
review paper in reputed journals and has contributed several chapters in
books on pharmaceutical and indigenous drugs. He is a member of various professional and academic
bodies like Association of Pharmaceutical Teachers of India (APTI) and the Society of Pharmacognosy.
Nagendra Singh Chauhan obtained his MPharm and PhD from
Department of Pharmaceutical Sciences, Dr. H.S. Gour University,
Sagar in 2006 and 2011. He has around 14 years of research experience.
He is presently working as Senior Scientific Officer Grade-II and
Government Analyst at Drugs Testing Laboratory avam Anusandhan
Kendra, Raipur, Chhattisgarh, India. He has professional expertise in
natural product isolation. He also has hands-on experience in various
techniques like extraction, isolation, and purification of natural products
from plant extracts using various chromatographic techniques for
separation of compounds including column, LC-MS, chromatography,
preparative TLC, and structure elucidation of natural products with the
help of various techniques like UV, mass, IR, and NMR. He is well
versed with the design, conduct, and data treatment of various in vivo
experiments like aphrodisiac, antidiabetic, anti-stress, hair growth,
BPH, hepatoprotective, and reproductive parameters. He has written more than 50 articles published in
national and international journals and 20 book chapters. He has more than 1400 citations with h-index
21 and i10 index of 32 (Google scholar) and scopus h-index 15; 669 citations. He is a member of various
professional and academic bodies like Society of Pharmacognosy, International Natural Product Sciences
Taskforce (INPST) Society, SILAE: Società Italo-Latinoamericana di Etnomedicina (The Scientific
Network on Ethnomedicine, Italy), Institutional Human ethical committee, and the Association of
Pharmaceutical Teachers of India (APTI).
