Novel Therapies for CNS Injuries : Rationales and Results book cover
1st Edition

Novel Therapies for CNS Injuries
Rationales and Results

ISBN 9780849376528
Published December 12, 1995 by CRC Press
416 Pages

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Book Description

This book provides reviews of the epidemiology, evaluation, and patient management of central nervous system (CNS) injuries. Internationally recognized clinicians and basic scientists discuss recent research that has significantly advanced the understanding of the pathophysiology of neuronal death and facilitated development of new therapeutic approaches.
Novel therapeutic agents evaluated in animal models and currently in clinical trials include:
calcium antagonists
glutamate receptor antagonists
inhibitors of glutamate release
endothelial adhesion and nerve growth factors
antioxidants, gangliosides
thrombolytic agents
All of these options, as well as hypothermia as a potentially therapeutic approach, are discussed in this comprehensive volume. It will be invaluable to neurologists, neurosurgeons, intensivists, and emergency medicine physicians who care for CNS injured patients.

Table of Contents

Traumatic and Ischemic Injuries to the Brain and Spinal Cord
Traumatic Brain Injury; Epidemiology, Pathophysiology, and Classification, P.L. Peterson, A. Guyot, and R.D. Zafonte
Spinal Cord Injury; Epidemiological Studies, Diagnosis, and Classification, P.R. Aldana and B.A. Green
Risk Factors and Primary Prevention of Strokes, A.J. Orencia and J. Biller
Current Management Strategies
Current Management Strategies for Traumatic Brain and Spinal Cord Injuries, J.P. Muizelaar and P.L. Peterson
Current Management Strategies for Cerebrovascular Stenosis; Prophylaxis and Treatment, J. Weinberger
Novel Experimental Therapies for CNS Injuries
Thrombolysis in Stroke, A. Durocher and J. Biller
Platelet-Activating Factor Antagonists, D.D. Gilboe, J.H. Fitzpatrick,Jr., and D.B. Kintner
Excitatory Amino Acid Pharmacology in Traumatic Brain Injury, D.H. Smith and T.K. McIntosh
Excitatory Amino Acid Receptor Antagonists in the Treatment of Ischemia, J.W. Phillis
Glutamate Release Inhibition, M.J. Leach and J.H. Swan
Calcium Antagonists for Therapy of Disorders of the Nervous System, S.M. Goldin, R.N. McBurney, and T.J. Turner
Nonenzymic Inhibitors of Free Radical Production, J.W. Phillis
21-Aminosteroids in Acute CNS Injury and Ischemia, E.D. Hall
Antioxidant Enzymes in Cerebral Ischemia and Trauma, G.T. Gobbel and P.H. Chan
Clinical and Laboratory Basis of Hypothermia for the Treatment of Severe Head Injury, G.L. Clifton, C.E. Dixon, and R.L. Hayes
Neuroregeneration as a Repair Mechanism in Brain Injuries: Pharmacological Role of Growth-Promoting Factors, A. Gorio and A.M. di Giulio
Gangliosides, F.H. Geisler
Nitric Oxide, Trophic Factors, and Cerebral Injury, K. Maiese
Purinergic Interventions in Traumatic and Ischemic Injury, K.A. Rudolphi and P. Schubert
The Role of Calcium-Activated Proteolysis in Ischemic Brain Injury, K.S. Lee
Endothelial Adhesion Factors in Traumatic and Ischemic Injuries of the Brain and Spinal Cord, R.M. McCarron
Experimental Therapeutic Opioid Interventions in Traumatic CNS Injury, B.G. Lyeth

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