Novel Therapies for CNS Injuries: Rationales and Results, 1st Edition (Hardback) book cover

Novel Therapies for CNS Injuries

Rationales and Results, 1st Edition

By Patti L. Peterson, John W. Phillis

CRC Press

416 pages

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Hardback: 9780849376528
pub: 1995-12-12
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This book provides reviews of the epidemiology, evaluation, and patient management of central nervous system (CNS) injuries. Internationally recognized clinicians and basic scientists discuss recent research that has significantly advanced the understanding of the pathophysiology of neuronal death and facilitated development of new therapeutic approaches.

Novel therapeutic agents evaluated in animal models and currently in clinical trials include:

calcium antagonists

glutamate receptor antagonists

inhibitors of glutamate release

endothelial adhesion and nerve growth factors


antioxidants, gangliosides

thrombolytic agents

All of these options, as well as hypothermia as a potentially therapeutic approach, are discussed in this comprehensive volume. It will be invaluable to neurologists, neurosurgeons, intensivists, and emergency medicine physicians who care for CNS injured patients.

Table of Contents


Traumatic and Ischemic Injuries to the Brain and Spinal Cord

Traumatic Brain Injury; Epidemiology, Pathophysiology, and Classification, P.L. Peterson, A. Guyot, and R.D. Zafonte

Spinal Cord Injury; Epidemiological Studies, Diagnosis, and Classification, P.R. Aldana and B.A. Green

Risk Factors and Primary Prevention of Strokes, A.J. Orencia and J. Biller

Current Management Strategies

Current Management Strategies for Traumatic Brain and Spinal Cord Injuries, J.P. Muizelaar and P.L. Peterson

Current Management Strategies for Cerebrovascular Stenosis; Prophylaxis and Treatment, J. Weinberger

Novel Experimental Therapies for CNS Injuries

Thrombolysis in Stroke, A. Durocher and J. Biller

Platelet-Activating Factor Antagonists, D.D. Gilboe, J.H. Fitzpatrick,Jr., and D.B. Kintner

Excitatory Amino Acid Pharmacology in Traumatic Brain Injury, D.H. Smith and T.K. McIntosh

Excitatory Amino Acid Receptor Antagonists in the Treatment of Ischemia, J.W. Phillis

Glutamate Release Inhibition, M.J. Leach and J.H. Swan

Calcium Antagonists for Therapy of Disorders of the Nervous System, S.M. Goldin, R.N. McBurney, and T.J. Turner

Nonenzymic Inhibitors of Free Radical Production, J.W. Phillis

21-Aminosteroids in Acute CNS Injury and Ischemia, E.D. Hall

Antioxidant Enzymes in Cerebral Ischemia and Trauma, G.T. Gobbel and P.H. Chan

Clinical and Laboratory Basis of Hypothermia for the Treatment of Severe Head Injury, G.L. Clifton, C.E. Dixon, and R.L. Hayes

Neuroregeneration as a Repair Mechanism in Brain Injuries: Pharmacological Role of Growth-Promoting Factors, A. Gorio and A.M. di Giulio

Gangliosides, F.H. Geisler

Nitric Oxide, Trophic Factors, and Cerebral Injury, K. Maiese

Purinergic Interventions in Traumatic and Ischemic Injury, K.A. Rudolphi and P. Schubert

The Role of Calcium-Activated Proteolysis in Ischemic Brain Injury, K.S. Lee

Endothelial Adhesion Factors in Traumatic and Ischemic Injuries of the Brain and Spinal Cord, R.M. McCarron

Experimental Therapeutic Opioid Interventions in Traumatic CNS Injury, B.G. Lyeth


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Critical Care
MEDICAL / Neurology
SCIENCE / Life Sciences / Neuroscience