Edited by a renowned international expert in the field, Nuclear Medicine Physics offers an up-to-date, state-of-the-art account of the physics behind the theoretical foundation and applications of nuclear medicine. It covers important physical aspects of the methods and instruments involved in modern nuclear medicine, along with related biological topics.
The book first discusses the physics of and machines for producing radioisotopes suitable for use in conventional nuclear medicine and PET. After focusing on positron physics and the applications of positrons in medicine and biology, it describes the use of radiopharmaceuticals in molecular imaging, clinical, and research studies. The text then covers modern radiation detectors and measuring methods, including those used in nuclear imaging, as well as numerous imaging methodologies and models, such as two- and three-dimensional image reconstruction algorithms, data processing sequences, new nuclear oncology techniques, and physiological models of the central nervous system. It also introduces biological systems theory, nuclear medicine methods as systems theory procedures, and aspects of kinetic modeling. The final chapter explores dosimetry and the biological effects of ionizing radiation.
With many new developments occurring in nuclear medicine, it is important to understand how advanced approaches are being used in emerging applications. Offering invaluable insight into this growth, Nuclear Medicine Physics provides in-depth descriptions of new radiolabeled biological drugs, new cell labeling techniques, new technical concepts in radiation detection, improvements in instrumentation, and much more.
Table of Contents
Introduction, J.J. Pedroso de Lima
Cyclotron and Radionuclide Production, Francisco J.C. Alves
The Quantitative Aspects of Radionuclide Production
The Cyclotron: Physics and Acceleration Principles
Positron Physics, Adriano Pedroso de Lima and Paulo M. Gordo
The Physical and Chemical Aspects of the Positron and Positronium in Matter
Perspectives on the Medical Applications of Positrons
Radiopharmaceuticals: Development and Main Applications, Antero Abrunhosa and M. Isabel Prata
Radiochemistry and Radiopharmacy in Conventional Nuclear Medicine and PET
Advances in Radiopharmacy and New Trends in Radiochemistry
Radiation Detectors and Image Formation, Francisco J. Caramelo, Carina Guerreiro, Nuno C. Ferreira, and Paulo Crespo
The Physics of Detection Methods
Instrumentation in Nuclear Medicine Imaging: SPECT and PET
Imaging Methodologies, Nuno C. Ferreira, Francisco J. Caramelo, J.J. Pedroso de Lima, Carina Guerreiro, M. Filomena Botelho, Durval C. Costa, Hélder Araújo, and Paulo Crespo
Physical Aspects of the Image in Nuclear Medicine
Reconstruction and Data and Image Processing in Nuclear Medicine
Advanced Methods in Nuclear Oncology
The Central Nervous System: Physiological Models and Clinical Applications
Systems in Nuclear Medicine, J.J. Pedroso de Lima, and António Dourado
Biological Systems Theory and Kinetic Modeling of Radiotracers
Dosimetry and Biological Effects of Radiation, Augusto D. Oliveira and J.J. Pedroso de Lima
Ionizing Radiations: Physics, Dosimetry, and Protection
The Physics of the Biological Effects of Radiation
Nontargeted Effects: Another Option for Low-Dose Radiation Action
João José Pedroso de Lima is a professor emeritus of biophysics at the University of Coimbra in Portugal, where he was president of the executive board of the Institute of Biomedical Research in Light and Image (IBILI). Dr. Lima has published numerous papers and has received over twenty scientific awards, including an honorary degree by the University of Aveiro. His main research interests include nuclear medicine physics, biomedical systems, and biophysics of respiration.
… The data contained here will no doubt prove vital to researchers in multiple disciplines (physics, nuclear medicine, oncology) looking for ways to expand and upgrade patient care (specifically, oncologists charged with diagnosing and treating various forms of cancer will immediately benefit from learning how nuclear imaging techniques can enhance the patient experience in the clinical setting).
—The Electric Review, January 2011