Ocular Theraputics and Drug Delivery  book cover
1st Edition

Ocular Theraputics and Drug Delivery

ISBN 9781566762137
Published December 12, 1995 by CRC Press
587 Pages

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Book Description

Since ocular therapeutics and drug delivery is a subject of interest to specialists from various disciplines such as chemical, biochemical, medical, pharmaceutical, and toxicological, it truly presents a unique situation requiring a multi-disciplinary approach in understanding and addressing various problems. Yet we see that scientists associated with these areas are working, by and large, independently of one another, thus limiting dissemination of knowledge, experience and ideas that would greatly enhance the overall progress in this area of research. Regrettably, the information currently available in ocular therapeutics and drug delivery, though extensive, is still fragmented into various disciplines making meaningful synthesis difficult. Several books are available that cover one or two aspects of the multi-disciplinary fields on an individual basis; however, none is available that covers all of them. The chapters contained in this book are specific to various interrelated areas of ocular therapeutics and drug delivery and are written by acknowledged experts from both academia and industry. The book itself is divided into five parts, namely: (I) overview,basic principles, and methodology; (II) pathopharmacology and clinical applications; (III) chemical/ biochemical approaches to ocular drug delivery; (IV) formulation and drug delivery considerations; and (V) industrial and regulatory considerations.
Individual chapters in each section, apart from presenting a concise text, entail an extensive listing of references.

Table of Contents

Part I: Overview, Basic Principles and Methodology

Ocular Therapeutics and Drug Delivery: An Overview - Indra K. Reddy, Ph.D., St. John's University, and Madurai G. Ganesan, Ph.D., American Cyanamid Company
Surface Chemical Aspects of Ocular Drug Delivery Systems - C. P. Singh, Ph.D., and Dinesh O. Shah, Ph.D., University of Florida
Biological Barriers to Ocular Drug Delivery - John C. Lang, Ph.D., Alcon Laboratories, Inc., and Monica M. Stiemke, Ph.D., University of Texas Health Science Center at Houston
Pharmacodynamic and Pharmacokinetic Correlations of Ophthalmic Drugs - Diane D.-S. Tang-Liu, Ph.D., and Andrew Acheampong, Ph.D., Allergan Inc.; Du-Shieng Chien, Ph.D., Miles, Inc.; and Joel I. Usansky, Ph.D., Allergan Inc.
Drug Metabolizing Enzyme Systems in the Eye - Gondi N. Kumar, Ph.D., Medical University of South Carolina

Part II: Pathopharmacology and Clinical Applications

Artificial Tear Formulations, Irrigating Solutions and Contact Lens Products - Indra K. Reddy, Ph.D., Wahid Aziz, and Robert B. Sause, Ph.D., R.Ph., St. John's University
Clinical Pharmacology of the Anterior Segment of the Eye - Michael A. Barletta, Ph.D., and Indra K. Reddy, Ph.D., St. John's University
Recent Developments in Anti-Glaucoma Drug Research - Markku Leino, M.D., Ph.D., and Arto Urtti, Ph.D., University of Kuopio, Finland
Vitreoretinal Diseases: Pathological Aspects and Therapeutic Strategies - Gholam A. Peyman, M.D., Louisiana State University

Part III: Chemical/Biochemical Approaches to Ocular Drug Delivery

Prodrugs: A Chemical Approach to Ocular Drug Delivery - Vijay K. Tammara, Ph.D., Food and Drug Administration, and Michael A. Crider, Ph.D., Northeast Louisiana University
The Use of Retrometabolic Drug Design Concepts in Ophthalmic Drug Discovery - Nicholas Bodor, Ph.D., D.Sc., University of Florida
Development of Soft Drugs for Ophthalmic Use - John F. Howes, Ph.D., Pharmos Corp.

Part IV: Formulation and Drug Delivery Considerations

Topical Ophthalmic Formulation: Basic Considerations - Nutan K. Gangrade, Ph.D., Nehru B. Gaddipati, Ph.D., and Madurai G. Ganesan, Ph.D., American Cyanamid Co.; and Indra K. Reddy, Ph.D., St. John's University
Polymers in Ophthalmic Drug Delivery Systems - Mansoor A. Khan, Ph.D., Northeast Louisiana University, and Manzer J. Durrani, Ph.D., BFGoodrich
Microparticulates as Ocular Delivery Systems - Abhay Joshi, Ph.D., Allergan Inc.
Protein and Peptide Drug Delivery to the Eye - Ajay K. Banga, Ph.D., University of Auburn
Evaluation of Primary Ocular Irritation: Alternatives to the Draize Test - Christine M. Hutak, Ph.D., New York College of Osteopathic Medicine, and Richard B. Jacaruso, M.S., D.O., Winthrop University Hospital

Part V: Industrial and Regulatory Considerations

Packaging Aspects of Ophthalmic Products - Nehru B. Gaddipati, Ph.D., Nutan K. Gangrade, Ph.D., and Madurai G. Ganesan, Ph.D., American Cyanamid Co.; and Indra K. Reddy, Ph.D., St. John's University
A Brief History of Drug Regulation and Regulatory Issues Governing Ophthalmic Products: A Biopharmaceutic Perspective - Vijay K. Tammara, Ph.D., Raman K. Baweja, Ph.D., Angelica G. Dorantes, Ph.D., and John P. Hunt, B.S., Food and Drug Administration

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Reddy, Indra K.


"Collectively, the book emerges as a comprehensive, interdisciplinary text that will certainly establish the current basis of ocular therapeutics and drug delivery system design. Dr. Reddy has assembled a group of excellent authors and timely topics to produce a text that should set the standard for the field."

- Joseph R. Robinson, Ph.D., Division Chair and Professor of Pharmacy and Ophthalmology, University of Wisconsin, Madison From the Preface