Based on the premise that many, if not most, reactions in organic chemistry can be explained by variations of fundamental acid-base concepts, Organic Chemistry: An Acid-Base Approach provides a framework for understanding the subject that goes beyond mere memorization. The individual steps in many important mechanisms rely on acid-base reactions, a
Introduction. Bonding. Alkanes, Isomers, and an Introduction to Nomenclature. Functional Groups. Acids, Bases, Nucleophiles, and Electrophiles. Chemical Reactions, Bond Energy, and Kinetics. Rotamers and Conformation. Stereoisomers: Chirality, Enantiomers, and Diastereomers. Acid-Base Reactions of p-Bonds. Nucleophiles: Lewis Base-Like Reactions at sp3 Carbon. Base-Induced Elimination Reactions. Substitution and Elimination Reactions Can Compete. Spectroscopic Methods of Identification. Organometallic Reagents. Carbonyl Compounds: Structure, Nomenclature, Reactivity. Oxidation. Reactions of Aldehydes and Ketones. Reduction. Carboxylic Acid Derivatives and Acyl Substitution. Aromatic Compounds and Benzene Derivatives. Enolate Anions: Acyl Addition and Acyl Substitution. Difunctional Molecules: Dienes and Conjugated Carbonyl. Compounds.Difunctional Molecules: Pericyclic Reactions. Disconnections and Synthesis. Heteroaromatic Compounds. Multifunctional Compounds: Amino Acids and Peptides. Multifunctional Compounds: Carbohydrates. Index.