The concept of general oxidoreductase function at the plasma level is new. Oxidoreduction at the Plasma Membrane: Relation to Growth and Transport provides the first truly comprehensive coverage of the oxidoreduction reactions in plasma membranes and the role that can now be attributed to these enzymes in controlling growth and other cell functions in plants and animals. The book describes the nature and orientation of oxidoreductases in plasma membranes; the stimulation of cell growth by oxidants reacting with transplasma membrane electron transport; changes in enzymes in tumor cells; and the basis of the growth effects and oxidoreductase stimulation of membrane transport in relation to known second messenger functions, such as cellular pH changes, calcium transport, protein phosphorylation and oxidation levels of pyridine nucleotides. The book then examines the significance of these enzymes in cell culture, tumor growth, nerve transmission, ion transport, and membrane potential. The book also presents a new approach to understanding the action of antitumor drugs and herbicides. Biochemists, biologists, oncologists, cancer researchers, physiologists, and endocrinologists will find this an indispensible reference source as they conduct studies in this exciting new area.
VOLUME I: ANIMALS
Historical Perspective. Oxidoreductase Enzymes in the Plasma Membrane. NADH Oxidase. Oxidation-Reduction Reactions in Secretory Vesicles. Hormone Control of Plasmalemma Electron Transport. The Stimulation of Cell Growth by Extracellular Oxidants. Transmembrane Electron Transport and Growth of Transformed Cells. Confounding Activities of Pyruvate and Ferric Coordination Complexes in the Analysis of Their Contributions to Cell Growth: Hydroperoxide Resistance or Direct Modulation of Cell Activities? Iron Supply and Cell Growth Control. Transferrin Receptor Growth Control in Normal and Transformed Cells. Role of Pyridine Nucleotides in Control of Cell Growth. Na+: H+ Antiport. Plasma Membrane Oxidoreduction and Amino Acid Transport. Interactions of Antitumor Drugs with Plasma Membranes. Redox Control of Neurotransmitter Action. Index.