Oxidative stress induced by the over-production of free radicals and other reactive species is implicated in the pathophysiology of a wide range of human diseases. The evidence implicating oxygen radicals in the etiology of 11 different human diseases or conditions is investigated in this volume. The data supporting this involvement is reviewed and the implications that result are discussed. Topics covered include: Alzheimer's disease; cerebral ischemia; rheumatoid arthritis; inflammatory bowel disease; atherosclerosis; ARDS; critical care medicine; and cancer.
Table of Contents
Free radicals and human disease - trick or treat?; oxygen free radical involvement in cerebral ischemia/reperfusion injury; oxygen radicals and ageing; free radicals in rheumatoid arthritis - redox regulation of gene transcription and proteolytic tissue destruction; implication of reactive oxygen metabolites in inflammatory bowel disease; interleukin-1, neutrophils and oxidants in acute lung injury; free radicals and critical care medicine; human immunodeficiency virus-1 tat protein and oxidant/antioxidant balance; role of reactive oxygen species in multistage carcinogenesis.
Craig Thomas (Author)