PARP as a Therapeutic Target: 1st Edition (Hardback) book cover

PARP as a Therapeutic Target

1st Edition

Edited by Jei Zhang

CRC Press

360 pages | 65 B/W Illus.

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pub: 2002-03-06
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Description

Recent research in cell death mechanisms has rekindled interest in PARP's (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors' dual actions of preventing cell death and abating inflammation have demonstrated remarkable acute effects in animal models of various diseases.

PARP as a Therapeutic Target covers the clinical aspects of this up-and-coming drug that counteracts the damage done by free radicals. Leading international experts currently working on ways to apply it share their views of recent developments and future directions of PARP research. They discuss its therapeutic potential in various disease conditions, such as ischemia, diabetes, cancer, arthritis, inflammatory bowel disease, and septic shock.

The intensified PARP drug development effort has raised expectations for possible clinical trials in the near future to establish the tolerance of PARP inhibitors in healthy humans, its efficacy in treating patients with different diseases, and the long term effect of PARP inhibition. PARP as a Therapeutic Target provides a comprehensive understanding of how PARP works to aid in the better design of its inhibitors for therapeutic purposes.

Table of Contents

Foreword

Nathan A. Berger

Preface

Jie Zhang

Nervous System Functions of Poly(ADP-Ribose) Polymerase-1

Krishna Juluri, Hyo Chol Ha, and Solomon H. Snyder

Role of Poly(ADP-ribose) Polymerase-1 in Neurologic Disorders

Marc F. Poitras, Valina L. Dawson, and Ted M. Dawson

Involvement of PARP-1 and Poly(ADP-Ribosyl)ation in the Maintenance of Genomic Stability

Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, Bassem H. Haddad, Danith Ly, Jie Zhang, and Mark E. Smulson

Functional Testing of Human PARP in Proliferation, Endotoxic Shock, and Radiosensitivity: A Genetic Rescue Study

Zdenko Herceg, Virginie Petrilli, Anton Wutz, Bernhard Auer, Marie-Pierre Cros, and Zhao-Qi Wang

PARP Inhibitors as Neuroprotective Agents for Brain Injury

Joel H. Greenberg, Michelle C. LaPlaca, and Tracy K. McIntosh

PARP Inhibitors and Cardioprotection

Christoph Thiemermann, Nicole Wayman, Michelle C. McDonald, and Prabal K. Chatterjee

Neuroprotection of the Retina with 3-Aminobenzamide, a PARP Inhibitor

Tim T. Lam

Poly(ADP-ribose) Polymerase Inhibitors and Acute Renal Failure

Prabal Kumar Chatterjee and Christoph Thiemermann

Role of Poly(ADP-ribose) Polymerase Activation in the Pathogenesis of Shock and Inflammation

Csaba Szabo

Clinical Development of the Nicotinamides and Benzamides Involving PARP as a Molecular Target

Ronald W. Pero, Anders Olsson, Hann Lindgren, and Tomas Leanderson

Chemoprotective Effect of a Novel PARP Inhibitor

Gyorgy Rabloczky, Laszlo Jaszlits, Gyorgy Bardos, Balazs Sumegi, Kalman Tory, Ildiko Racz, Beatrix Farkas, Attila Sandor, Zoltan Berente, Erzsebet Osz, Judit Szilvassy, Istvan Sziklai, Sandor Bernath, and Peter Literati Nagy

Beneficial Effect of GPI 6150 Treatment in Multiple Animal Models of Diseases

Jie Zhang

Protecting Effect of PARP Inhibition on Ultraviolet Light-Induced Skin Damage

Beatrix Farkas, Balazs Sumegi, Gyorgy Rabloczky, Bela Csete, Balazs Hodosi, Marta Magyarlaki, Sandor Bernath, and Peter Literati Nagy

Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Diabetes Mellitus and Diabetic Vascular Dysfunction

Jon Mabley, Laszlo Virag, and Csaba Szabo

Therapeutic Targeting of the PARPs: Future Challenges, Future Opportunities

Myron K. Jacobson and Elaine L. Jacobson

About the Series

Handbooks in Pharmacology and Toxicology

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Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI017000
SCIENCE / Life Sciences / Cytology