First published in 1986: Paradoxes play a key role in the advancement of science. They are associated with excitement, and with the knowledge that we must be looking at something the wrong way. This book discusses in detail Paradoxes in Immunology.
Table of Contents
1. The Problem of Antigen-Receptor Heterogeneity and the Coherent Regulation of the Immune Response
Peter A. Bretscher
2. Can a Mammalian Species with Monomorphic Class 1 MHC Molecules Succeed?
Alix G. Darden and J. Wayne Streilein
3. Immunological Quiescence Towards Self: Rethinking the Paradigm of Clonal Abortion
Erwin Diener and Cory A. Waters
4. The One Receptor Model and T-Cells with High Affinity for Nonself Other Than Alloantigen
Peter C. Doherty
5. Suppressor T-Cells Are Not Easily Cloned by Methods for Clothing Helper T-Cells
Diane D. Eardley and Pamela Hunt
6. Genetic Linkage of MHC and IGH-V-Linked Gene Products on T-Cell Regulatory Molecules
Patrick M. Flood
7. Anomalous Prolonged Allograft Survival after Deliberate Immunization against Graft-Specific Alloantigens
Reginald M. Gorczynski and Maria Robillard
Paul I. Terasaki
8. Tumor Dormancy as a Result of Simple Competition between Tumor Cells and Cytolytic Effector Cells
Jaques R. Hiernaux et al.
9. The Smell of H-2
Geoffrey W. Hoffman
10. Why Is the Immune System Not Overwhelmed by Suppression? A Reductionist Paradox
Robert H. Loblay and Antony Basten
11. Are Rheumatoid Factors Produced during Conventional Immune Responses Beneficial to the Host?
Audrey J. Manheimer-Lory and Constantin A. Bona
12. T-Cell Regulation without Clonal Selection by Antigen? Polygamous Suppressor Cells and Monogamous Helper Cells at High Frequencies
Inga Melchers and Klaus Eichmann
13. Does Clonal Selection Apply to T-Cells?
Richard G. Miller
14. B-Cells Can Be Activated in More Than One Way
N. Avrion Mitchison and Michael J.H. Ratcliffe
15. T-Cell Proliferation and Differentiation
N. Avrion Mitchison
16. Idiotypic Networks in Tumor Immunity
Karen A. Nelson and Gerald T. Nepom
17. The Paradox of Carbohydrate Histocompatibility Antigens
Christopher R. Parish
18. Paradoxes in B-Cell Stimulation by Polymeric Antigen and the Immunon Concept
Alan S. Perelson
19. Regulation of Idiotypic Profiles: Expected Dominance and Paradoxical Loss of T15 Expression
Jose Quintas and Gregory Wemhoff
20. The Isogeneic Barrier Revisited: Cell Dose Effects and Loss of MHC Control of Responses
Lydia Sikora and Julia G. Levy
21. Paradoxical Primary Response of (P1 x P2) F1 Female Mice to Male P1 and P2 Skin
22. Idiotypes, Allotypes, and a Paradox of Inheritance
23. Are There Unique 1 Region-Controlled Determinants on T-Cells?
Tomio Tada, Wojciech Uracz, and Ryo Abe
24. I-J – Immunoregulatory Molecules in Search of a Gene
25. Differences in the Recognition of MHC Class 1 Molecules by T-Cells and Antibodies
Marie Rose van Schravendijk, John E. Coligan, and William E. Biddison
Geoffrey W. Hoffman is currently an Associate Professor in two departments at the University of British Columbia, namely, Physics and Microbiology.
Julia G. Levy is full Professor at the University of British Columbia in the Department of Microbiology.
Gerald T. Nepom is currently Director of the Division of Immunology at Virginia Mason Research Center in Seattle, Washington.