Paradoxes In Immunology  book cover
1st Edition

Paradoxes In Immunology

ISBN 9780367251710
Published February 27, 2021 by CRC Press
336 Pages

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Book Description

First published in 1986: Paradoxes play a key role in the advancement of science. They are associated with excitement, and with the knowledge that we must be looking at something the wrong way. This book discusses in detail Paradoxes in Immunology.

Table of Contents

1. The Problem of Antigen-Receptor Heterogeneity and the Coherent Regulation of the Immune Response

Peter A. Bretscher

2. Can a Mammalian Species with Monomorphic Class 1 MHC Molecules Succeed?

Alix G. Darden and J. Wayne Streilein

3. Immunological Quiescence Towards Self: Rethinking the Paradigm of Clonal Abortion

Erwin Diener and Cory A. Waters

4. The One Receptor Model and T-Cells with High Affinity for Nonself Other Than Alloantigen

Peter C. Doherty

5. Suppressor T-Cells Are Not Easily Cloned by Methods for Clothing Helper T-Cells

Diane D. Eardley and Pamela Hunt

6. Genetic Linkage of MHC and IGH-V-Linked Gene Products on T-Cell Regulatory Molecules

Patrick M. Flood

7. Anomalous Prolonged Allograft Survival after Deliberate Immunization against Graft-Specific Alloantigens

Reginald M. Gorczynski and Maria Robillard

Paul I. Terasaki

8. Tumor Dormancy as a Result of Simple Competition between Tumor Cells and Cytolytic Effector Cells

Jaques R. Hiernaux et al.

9. The Smell of H-2

Geoffrey W. Hoffman

10. Why Is the Immune System Not Overwhelmed by Suppression? A Reductionist Paradox

Robert H. Loblay and Antony Basten

11. Are Rheumatoid Factors Produced during Conventional Immune Responses Beneficial to the Host?

Audrey J. Manheimer-Lory and Constantin A. Bona

12. T-Cell Regulation without Clonal Selection by Antigen? Polygamous Suppressor Cells and Monogamous Helper Cells at High Frequencies

Inga Melchers and Klaus Eichmann

13. Does Clonal Selection Apply to T-Cells?

Richard G. Miller

14. B-Cells Can Be Activated in More Than One Way

N. Avrion Mitchison and Michael J.H. Ratcliffe

15. T-Cell Proliferation and Differentiation

N. Avrion Mitchison

16. Idiotypic Networks in Tumor Immunity

Karen A. Nelson and Gerald T. Nepom

17. The Paradox of Carbohydrate Histocompatibility Antigens

Christopher R. Parish

18. Paradoxes in B-Cell Stimulation by Polymeric Antigen and the Immunon Concept

Alan S. Perelson

19. Regulation of Idiotypic Profiles: Expected Dominance and Paradoxical Loss of T15 Expression

Jose Quintas and Gregory Wemhoff

20. The Isogeneic Barrier Revisited: Cell Dose Effects and Loss of MHC Control of Responses

Lydia Sikora and Julia G. Levy

21. Paradoxical Primary Response of (P1 x P2) F1 Female Mice to Male P1 and P2 Skin

Elizabeth Simpson

22. Idiotypes, Allotypes, and a Paradox of Inheritance

E.J. Steele

23. Are There Unique 1 Region-Controlled Determinants on T-Cells?

Tomio Tada, Wojciech Uracz, and Ryo Abe

24. I-J – Immunoregulatory Molecules in Search of a Gene

Carl Waltenbaugh

25. Differences in the Recognition of MHC Class 1 Molecules by T-Cells and Antibodies

Marie Rose van Schravendijk, John E. Coligan, and William E. Biddison

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Geoffrey W. Hoffman is currently an Associate Professor in two departments at the University of British Columbia, namely, Physics and Microbiology.

Julia G. Levy is full Professor at the University of British Columbia in the Department of Microbiology.

Gerald T. Nepom is currently Director of the Division of Immunology at Virginia Mason Research Center in Seattle, Washington.