Parkinson's Disease: 2nd Edition (Hardback) book cover

Parkinson's Disease

2nd Edition

Edited by Ronald F. Pfeiffer, Zbigniew K. Wszolek, Manuchair Ebadi

CRC Press

1,308 pages | 171 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9781439807149
pub: 2012-10-09
eBook (VitalSource) : 9780429149344
pub: 2012-10-09
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In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the importance of the non-motor features of the disease. Theories regarding the pathogenesis and pathophysiology of PD have also been refined, and new treatment modalities and advances implemented. Reflecting these changes, this second edition features new chapters devoted to genetic aspects of PD, non-motor features of the disease, and aspects of the pathophysiology, pathogenesis, and treatment of PD.


Praise for the First Edition:

"…an invaluable reference outlining our current understanding of this disease. … contains all the information that any student new to the field requires to develop a thorough understanding of PD. With chapters about everything from epidemiology, to theories of pathogenesis, and back to symptoms and treatment, this book covers the entire range of what we can know about a biological phenomenon, from the molecular, cellular and genetic levels, through to the whole human being and the entire human population. … accessible to both seasoned veterans of Parkinson’s research, looking for the last information in an area outside their direct expertise, and novices, trying to grasp an understanding of the extent of our current knowledge of PD."

—Elissa M. Strome, Department of Experimental Medical Science, Lund University, Sweden, in the Journal of Chemical Neuroanatomy

"I would recommend it highly to those with a specialist’s interest in Parkinson’s disease and to more general neurologists who want an accessible, readable guide to diagnosing and treating this disease."

New England Journal of Medicine

"… tightly constructed and well organized. It stands out as the most comprehensive volume available on this disorder."


"A new encyclopedic collection of clinical wisdom … the largest and most comprehensive of several reference books that focus on this illness … masterfully organized."

Parkinson’s Disease Update

Table of Contents


James Parkinson

Jennifer G. Goldman and Christopher G. Goetz

Parkinson’s Disease: Where Have We Been?

Lawrence W. Elmer

Parkinson’s Disease: Where Are We?

Raúl de la Fuente-Fernández


Epidemiology of Parkinson’s Disease: An Overview

Monica Korell and Caroline M. Tanner

Environmental Toxins and Parkinson’s Disease

Jason R. Cannon and Timothy J. Greenamyre

Rural Environment and Parkinson’s Disease

Daniel Strickland

Industrial and Occupational Exposures and Parkinson Disease

Samuel Goldman

Tetrahydroisoquinolines and Parkinson’s Disease

Mark S. LeDoux

Endogenous Neurotoxins in the Pathogenesis and Progression of Parkinson’s Disease

Shaik Shavali and Manuchair Ebadi


Overview of the Genetics of Parkinsonism

Mathias Toft and Zbigniew K. Wszolek

α-Synuclein and Parkinson’s Disease

Thomas Gasser

LRRK2-Associated Parkinson’s Disease

Jonathan Carr and Soraya BardienParkin-Associated Parkinson’s Disease

Anne Grünewald and Christine KleinPINK1- and DJ-1-Linked Parkinsonism

Eng-King Tan

Genetic and Bioinformatic Tools in Parkinson’s Disease

Tatiana Foroud and Nathan Pankratz

Clinical Features of Parkinson’s Disease

Tremor, Rigidity, and Bradykinesia

Kelvin L. Chou and Howard I. Hurtig

Gait Disorders in Parkinson’s Disease

Yacov Balash, Jeffrey M. Hausdorff, Tanya Gurevich, and Nir Giladi


Padraig O’Suilleabhain

Pain in Parkinson’s Disease

Blair Ford

Restless Legs Syndrome and Periodic Limb Movements of Sleep

Bryan T. Klassen and Charles H. Adler

Fatigue: A Common Comorbidity in Parkinson’s Disease

Anelyssa D’Abreu and Joseph H. Friedman

Visual Dysfunction in Parkinson’s Disease

Robert L. Rodnitzky

Visuo-Cognitive Dysfunctions in Parkinson’s Disease

Andrea Antal, Walter Paulus, and Ivan Bodis-Wollner

Olfactory Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes

Katerina Markopoulou and Bruce A. Chase

Insomnia and Excessive Daytime Sleepiness in Parkinson’s Disease

J.A. Van Gerpen and Pablo Castillo

REM Sleep Behavior Disorder

Aleksandar Videnovic and Cynthia L. Comella

Gastrointestinal Dysfunction in Parkinson’s Disease

Ronald F. Pfeiffer

Urological Dysfunction

Carlos Singer and Henry Moore

Sexual Dysfunction

Cheryl Waters and Janice Smolowitz

Cardiovascular Autonomic Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes

Valeria Iodice, David Low, Ekawat Vichayanrat, and Christopher J. Mathias

Disorders of Thermoregulation in Parkinson’s Disease

Thomas L. Davis

Respiratory Dysfunction

Holly Shill

Depression in Parkinson’s Disease

Steven P. Wengel, Dennis P. McNeilly, and William J. Burke

Anxiety and Parkinson Disease

Jeremy Quickfall, Michael Trew, and Oksana Suchowersky

Apathy in Parkinson’s Disease

Howard D. Weiss and Laura Marsh


Anne L. Barba, B. Kelly Changizi, Donald S. Higgins, Stewart A. Factor, and Eric S. Molho

Pathophysiology of Parkinson’s Disease

Animal Models of Basal Ganglia Injury and Degeneration and Their Application to Parkinson’s Disease Research

Giselle M. Petzinger and Michael W. Jakowec

Neuroanatomy of Parkinson’s Disease

Heiko Braak and Kelly Del Tredici-Braak

Neuropathology of Parkinson’s Disease

John E. Duda and Dennis W. Dickson

Neurophysiology of the Motor Disorder in Parkinson’s Disease

Gaëtan Garraux and Mark Hallett

Neurochemistry of Parkinson’s Disease: Dopamine

L. Charles Murrin

Pathophysiology of Parkinson’s Disease, Neurochemical Pathology: Other Neurotransmitters

Yoshikuni Mizuno

Theories of Pathogenesis

Oxidative Stress

Casey Cook and Leonard Petrucelli

Mitochondrial Dysfunction

Daniel G. Healy and A.H.V. Schapira


Fabio Blandini


Roger Kurlan

Protein Conformational and Metabolic Changes in Parkinson’s Disease

Kevin St. P. McNaught and C. Warren Olanow

Cell Death in Parkinson’s Disease

Shankar Sadasivan, Ané Korff, Ciaran J. Faherty, and Richard Jay Smeyne

Diagnosis of Parkinson’s Disease

Differential Diagnosis of Parkinson’s Disease

Serena W. Hung and Anthony E. Lang

Neuroleptic-Induced Movement Disorders

Manuchair Ebadi

Clinical Diagnostic Criteria for Parkinson’s Disease

Daniel Tarsy and Laurie Gordon

Clinical Batteries and Biomarkers in the Diagnosis of Parkinson’s Disease

Claire Henchcliffe and Un Kang

Rating Scales

Kathleen M. Shannon

MR Imaging of Parkinsonism

James B. Wood

Molecular Imaging in Parkinson Disease

Danna Jennings, David Russell, Ken Marek, and John Seibyl

Positron Emission Tomography in Parkinson’s Disease

Silke Appel-Cresswell, R. Nandhagopal, John R. Adams, and A. Jon Stoessl

Transcranial Ultrasound in Parkinson’s Disease

Daniela Berg, Bettina Faust, and Alexandra Gaenslen

In Vivo Molecular Imaging in Parkinson’s Disease

Sushil K. Sharma and Manuchair Ebadi

Placebo Effect in Parkinson’s Disease

Jayasri Srinivasan, Sarah C. Lidstone, Raúl de la Fuente-Fernández, and A. Jon Stoessl

Treatment of Parkinson’s Disease with Anticholinergic Medications

Duarte Machado and Bahman Jabbari


Kelly E. Lyons and Rajesh Pahwa

MAO-B Inhibitors for the Treatment of Parkinson’s Disease

John Bertoni

Catechol-O-Methyltransferase Inhibitors in the Treatment of Parkinson’s Disease

Mervat Wahba, Theresa A. Zesiewicz, and Robert A. Hauser

Symptomatic Treatment of Parkinson’s Disease: Levodopa

John L. Goudreau and J. Eric Ahlskog

Dopamine Agonists in Parkinson’s Disease

Joseph Jankovic and Toby C. Yaltho

Non-Dopaminergic Drugs for Motor Symptoms

Pierre R. Burkhard and Francois J.G. Vingerhoets

Stereotactic Ablative Procedures for Intractable Parkinson’s Disease

Marco Sassi and Michael S. Okun

Deep Brain Stimulation Surgery

Ryan J. Uitti, Yashiko Baba, and Robert E. Wharen Jr.

Neurotransplantation in the Treatment of Parkinson’s Disease

Penelope Hallett and Ole Isacson

Role of Physical Therapy in Management of Parkinson’s Disease

Rose Wichmann

Speech Therapy in the Treatment of Parkinson’s Disease

Shimon Sapir, Lorraine Ramig, and Cynthia Fox

Dysphagia in Parkinson’s Disease

Lisa A. Newman

Restorative and Functional Occupational Therapy in Parkinson’s Disease

Surya Shah

Neurologic Music Therapy: A Modality to Address the Diverse Needs of People with Parkinson’s Disease

Sandra L. Holten

Dance for Persons with Parkinson’s Disease*

Olie Westheimer

Pathogenesis of Motor Response Complications in Parkinson’s Disease: "Mere Conjectural Suggestions" and Beyond

Leo Verhagen Metman and Christina L. Vaughan

Treatment of Early Parkinson’s Disease

John C. Morgan and Kapil D. Sethi

Treatment of Moderate Parkinson’s Disease

John E. Duda and Matthew B. Stern

Management of Advanced Parkinson’s Disease

Grace S. Lin Liang and James W. Tetrud

Role and Design of Clinical Trials for Parkinson’s Disease

Andrew Siderowf and Stanley Fahn

Future Symptomatic Therapy in Parkinson’s Disease

Ruth Djaldetti, Shlomit Yust-Katz, and Eldad Melamed

Calcium Influx, Free Radicals, and Aging: A Metabolic Burden Linked to Neuronal Loss in Parkinson’s Disease

Javier Sanchez-Padilla, Jaime N. Guzman, and D. James Surmeier

Therapeutic Potential of Exercise in Parkinson’s Disease

Brian K. Schilling

Gene Therapy for Parkinson’s: Disease from Bench to Bedside

Fredric P. Manfredsson, Aaron C. Rising, M. Angela Cenci, Carmen S. Peden, and Ronald J. Mandel

Translating Stem Cell Biology to Regenerative Medicine for Parkinson’s Disease

Florian A. Siebzehnrubl and Dennis A. Steindler

Alternative Drug Delivery in the Treatment of Parkinson’s Disease

Pierre J. Blanchet

Economics of Parkinson’s Disease

Jessica Mastalski, Robert G. Holloway, and Katia Noyes

Informal Caregiving: An Essential Part of the Team

Carmen Dyck and Susan M. Calne

Driving in Parkinson’s Disease

Ergun Y. Uc

Evolution and Potential of the National Parkinson’s Organizations: A Brief Overview

Ruth A. Hagestuen

Comprehensive Parkinson’s Disease Care in Complex Environments

Elaine Cohen, Monique Giroux, Ruth A. Hagestuen, and Gladys Gonzalez-Ramos


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Geriatrics
MEDICAL / Neurology
SCIENCE / Life Sciences / Neuroscience