Particle Toxicology: 1st Edition (Hardback) book cover

Particle Toxicology

1st Edition

Edited by Ken Donaldson, Paul Borm

CRC Press

456 pages | 5 Color Illus. | 101 B/W Illus.

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pub: 2006-12-21
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Description

Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. 

Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of “dose” dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research.

Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop new concepts to understanding particle actions, measurement, testing, and pathogenic exposure to fine and ultrafine particles.

Reviews

“This book contains  22 chapters written by 49 well-recognized international experts who are active in the field of particle toxicology. The extensive bibliography at the end of each chapter provides additional information for readers who wish to explore the subject further. … The authors have presented a clear and authoritative account of what is known about particle toxicology as well as indications of what is unknown. References are reviewed in depth, relevant areas are covered, and the information is presented in a manner that can be grasped by research academics, industrial scientists, and students, as well as those individuals responsible for establishing regulatory policies for airborne contaminants. The chapters are rich with graphs, figures, microphotographs, and tables that are pertinent and helpful in interpreting the text. The strength of this book lies in its in-depth coverage of particle toxicology in terms of models, methods, risk assessment, and health effects. This book successfully integrates a wide variety of evidence and interpretations of the existing animal, human, and short-term in vitro data in this rapidly advancing field of toxicology. … providing the reader with more than a simple review of what has been done, and also presenting issues and concepts that are important to the future development of particle toxicology. …”

— Donald E. Gardner, Editor-in Chief, in Inhalation Toxicology, June 2007

“This well-written book…fully meets the challenge of insightfully summarizing and critically reviewing the state of the science for particle toxicology. …Special attention has been given to reviewing nanoparticle research. …The first few chapters are a must-read in terms of understanding the significance of the problem…. The authors have presented a clear and authoritative account of what is known about particle toxicology as well as indications of what is unknown. References are reviewed in depth, relevant areas are covered, and the information is presented in a manner that can be grasped by research academics, industrial scientists, and students, as well as those individuals responsible for establishing regulatory policies…. The chapters are rich with graphs, figures, microphotographs, and tables…. The strength of this book lies in its in-depth coverage of particle toxicology in terms of models, methods, risk assessment, and health effects. …The authors are to be congratulated for taking on this difficult but important task and carrying it out so well….”  

—Donald E. Gardner, Editor-in-Chief, Inhalation Toxicology, 19:787–788, 2007

Table of Contents

An Introduction to Particle Toxicology: From Coal Mining

to Nanotechnology, P. J. A. Borm and K. Donaldson

Mineralogy and Structure of Pathogenic Particles, T. Jones and K. BéruBé

Particle Dosimetry: Deposition and Clearance from the Respiratory Tract and Translocation towards Extra-Pulmonary Sites, W. G. Kreyling, G. Oberdorster, W. Möller, and M. Semmler-Behnke

Particulate Air Pollutants and Small Airway Remodeling, A. Churg

Particle-Mediated Extracellular Oxidative Stress in the Lung, F. J. Kelly and I. S. Mudway

Particles and Cellular Oxidative and Nitrosative Stress, D. W. Porter, S. S. Leonard, and V. Castranova

Interaction of Particles with Membranes, B. Rothen-Rutishauser, S. Schürch, and P. Gehr

 Particle-Associated Metals and Oxidative Stress in Signaling, J. M. Samet and A. J. Ghio

Proinflammatory Effects of Particles on Macrophages and Epithelial Cells, V. Stone, P. G. Barlow, G. R. Hutchinson, and D. M. Brown

Cell-Signaling Pathways Elicited by Particulates, J. E. Levis and B. T. Mossman

Particle-Associated Organics and Proinflammatory Signaling, F. Marano, S. Boland, and A. Baeza-Squiban

The Asbestos Model of Interstitial Pulmonary Fibrosis: TNF-a and TGF-b1 as Mediators of Asbestos-Induced Lung Fibrogenesis, D. E. Sullivan and A. R. Brody

Effects of Particles on the Immune System, I. Gilmour, T. Stevens, and R. K. Saxena

Effects of Particles on the Cardiovascular System, N. Mills, D. E. Newby, W. MacNee, and K. Donaldson

Susceptibility to Particle Effects, S. R. Kleeberger and R. Howden

Genotoxic Effects of Particles, R. P. F. Schins and T. K. Hei

Approaches to the Toxicological Testing of Particles, K. Donaldson, S. Faux, P. Borm, and V. Stone

Models for Testing the Pulmonary Toxicity of Particles: Lung Bioassay Screening Studies in Male Rats with a New Formulation of TiO2 Particulates, D. B. Warheit, K. L. Reed, and C. M. Sayes

Air Pollution and Human Brain Pathology: A Role for Air Pollutants in the Pathogensis of Alzheimer’s Disease, L. Calderón-Garcidueñas and W. Reed

Biologically-Based Lung Dosimetry and Exposure-Dose-Response Models for Poorly Soluble Inhaled Particles, L. Tran and E. Kuempel

Nanoparticles in Medicine, P. J. A. Borm and D. Muller-Schulte

The Toxicology of Inhaled Particles: Summing Up an Emerging Conceptual Framework, K. Donaldson, L. Tran, and P. Borm Index

Subject Categories

BISAC Subject Codes/Headings:
MED079000
MEDICAL / Pulmonary & Thoracic Medicine
MED096000
MEDICAL / Toxicology
SCI026000
SCIENCE / Environmental Science