Peptide and Protein Drug Analysis: 1st Edition (Hardback) book cover

Peptide and Protein Drug Analysis

1st Edition

Edited by Ronald Reid

CRC Press

904 pages

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Description

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design.

Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication.

Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis

  • discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability

  • analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology

  • examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods

  • highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry

  • demonstrates uses of unnatural mutagenesis and combinatorial chemistry

  • explores mass spectrometry, protein sequence, and carbohydrate analysis

  • illustrates bioassays and other new functional analysis methods

  • surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR)

  • addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells

  • reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering

  • and more!

    Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.

  • Reviews

    "

    …an excellent book covering all aspects of peptide and protein chemistry, structure and analysis.

    "-Pharmaceutical Research

    Table of Contents

    Strategies

    Practical Principles of Protein Design,

    Ronald E. Reid and Patrick L. Franchini

    Peptidomimetic and Nonpeptide Drug Discovery: Concepts, Strategies, and Technologies, Tomi K. Sawyer

    Structure Prediction and Molecular Modeling,

    Robin E. J. Munro and William R. Taylor

    Chemical Synthesis of Peptides, Henriette A. Remmer and Gregg B. Fields

    Chemical Synthesis of Proteins, Graham J. Cotton, Maria C. Pietanza, and Tom W. Muir

    Introduction of Unnatural Amino Acids into Proteins, Scott A. Lesley

    Combinatorial Chemistry and the Structure-Function Analysis of Proteins, Rachel L. Winston and Michael C. Fitzgerald

    Folding Polypeptides for Drug Production and Discovery, Elizabeth Strickland, Philip J. Thomas, and Ming Li

    Protein and Peptide Chemical and Physical Stability,

    Bernard N. Violand and Ned R. Siegel

    Bioinformatics and Computational Chemistry in Molecular Design: Recent Advances and Their Applications, Jin Li and Barry Robson

    Chemical Analysis

    High Pressure Liquid Chromatography of Peptides and Proteins, Marie-Isabel Aguilar

    Practical Aspects of Peptide and Protein Analysis by Capillary Electrophoresis, Nicole J. Munro, Andreas Hühmer, and James P. Lander

    Gel Electrophoresis of Peptides and Proteins, Michael J. Dunn

    Carbohydrate Analysis of Glycoproteins and Glycopeptides, Nigel Jenkins, Pir M. Shah, and Lorraine D. Buckberry

    Protein Sequence Analysis, Hsieng S. Lu, Lee Anne Merewether, and Michael F. Rohde

    Mass Spectrometry, Vic Garner

    Functional Analysis

    Protein and Peptide Immunoassays, Anthony B. Chen

    Pharmacogenomics, Ann K. Daly and Jane Grove

    Analysis of Polypeptide Bioactivity, David C. Wood, Q. Khai Huynh, and Joseph B. Monahan

    Pharmacokinetics and Pharmacodynamics of Protein Therapeutics, Rene Braeckman

    Approaches to Validating the Identity of Peptides and Proteins,

    Ian R. Tebbett and Nancy D. Denslow

    Structural Analysis

    Solution Structure Determination of Proteins by Nuclear Magnetic Resonance Spectroscopy, Nicholas J. Skelton and Walter J. Chazin

    NMR Studies of Protein-Peptide Complexes: Examples from the Calmodulin System, A. Joshua Wand, Jeffrey L. Urbauer, Mark R. Ehrhardt, and Andrew L. Lee

    Circular Dichroism and Fourier Transform Infrared Analysis of Polypeptide Conformation, Graeme J. Anderson

    Electron Paramagnetic Resonance of Peptides and Proteins, Derek Marsh

    UV-Visible and Fluorescence Spectroscopy of Polypeptides and Proteins, G. M. Anantharamaiah, Vinod K. Mishra, Geeta Datta, and Herbert C. Cheung

    Ultracentrifugation, Light-, X-ray-, and Neutron-Scattering of Peptides, Proteins and Nucleic Acids in Solution, Henryk Eisenberg

    About the Editor

    Ronald E. Reid

    Subject Categories

    BISAC Subject Codes/Headings:
    MED071000
    MEDICAL / Pharmacology
    SCI013000
    SCIENCE / Chemistry / General