5th Edition
Percutaneous Absorption Drugs, Cosmetics, Mechanisms, Methods
Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel.
Key Features:
- Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption
- Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery
- Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption
Chapter 1 Molecular structure and function of the skin barrier
Lars Norlén
Chapter 2 Mathematical Models in Percutaneous Absorption
Michael S. Roberts and Yuri G. Anissimov
Chapter 3 In Vivo Percutaneous Absorption: A Key Role for Stratum Corneum/ Vehicle Partitioning
André Rougier
Chapter 4 The Skin Reservoir for Topically Applied Solutes
Michael S. Roberts, Sheree E. Cross, and Yuri G. Anissimov
Chapter 5 Chemical Partitioning into Powdered Human Stratum Corneum: A Useful In Vitro Model for Studying Interaction of Chemicals and Human Skin
Xiao-Ying Hui and Howard I. Maibach
Chapter 6 Variations of Hair Follicle Size and Distribution in Different Body Sites
Nina Otberg, Heike Richter, Hans Schaefer, Ulrike Blume-Peytavi, Wolfram Sterry, and Jürgen Lademann
Chapter 7 In Vivo Relationship Between Percutaneous Absorption and Transepidermal Water Loss
André Rougier, Claire Lotte, Howard I. Maibach
Chapter 8 The correlation between transepidermal water loss and percutaneous absorption: An updated overview
Marjan Koosha Johnson, Jacquelyn Levin*, and Howard Maibach
Chapter 9 Human Percutaneous Absorption and Transepidermal Water Loss (TEWL) Correlation
Howard I.Maibach
Chapter 10 Evaluation of Stratum Corneum Heterogeneity
Gerald B. Kasting, Matthew A. Miller, and Priya S. Talreja
Chapter 11 Regional Variation in Percutaneous Absorption: Principles and Applications to Human Risk Assessment
Ronald C. Wester and Howard I. Maibach
Chapter 12 Effects of Anatomical Location on In Vivo Percutaneous Penetration in Man
Jordan L Bormann and Howard Maibach
Chapter 13 Interrelationships in the Dose-Response of Percutaneous Absorption
Ronald C. Wester and Howard I. Maibach
Chapter 14 Effects of Occlusion: Percutaneous Absorption
Nina Dragicevic and Howard I. Maibach
Chapter 15 Occlusion Does Not Uniformly Enhance Penetration In Vivo
Daniel Bucks and Howard Maibach
Chapter 16 Effect of Single vs. Multiple Dosing in Percutaneous Absorption
Howard I.Maibach
Chapter 17 Influence of formulation on topical and transdermal drug delivery
Heather A.E Benson, Hamid R. Moghimi, Jeffrey E. Grice and Michael S. Roberts
Chapter 18 In Vitro Release from Semisolid Dosage Forms—What Is Its Value?
Vinod P Shah
Chapter 19 Understanding Skin Metabolism: Effect on Altering In Vitro Skin Absorption and Bioavailability of Topically Applied Chemicals
Jeffrey J. Yourick and Margaret E.K. Kraeling
Chapter 20 Phenomenon of Lateral Spread in Percutaneous Penetration
Rebecca M. Law, Howard I. Maibach
Chapter 21 Clinically Pertinent Factors/Observations Affecting Percutaneous Absorption in Humans
Rebecca M Law, Mai A Ngo, Howard I Maibach
Chapter 22 Percutaneous Absorption of Chemical Mixtures
Jim E. Riviere
Chapter 23 Dermal Decontamination and Percutaneous Absorption
Howard I.Maibach
Chapter 24 Skin Decontaminartion
Annick Roul, Howard HI Maibach
Chapter 25 Chemical Warfare Agent VX Penetration Through Military Uniform and Human Skin: Risk Assessment and Decontamination
Howard I.Maibach
Chapter 26 Percutaneous Absorption of Hazardous Chemicals from Fabric into and Through Human Skin
Howard I.Maibach
Chapter 27 Percutaneous Absorption of Chemicals from Fabric (Textile)
Jordan L Bormann, Ayse Sermin Filiz Acipayam and Howard I Maibach
Chapter 28 The Fate of Material Remaining in Skin in In Vitro Absorption Studies
Margaret E.K. Kraeling and Jeffrey J. Yourick
Chapter 29 Skin Absorption of Hair Dyes
Margaret E.K. Kraeling and Jeffrey J. Yourick
Chapter 30 Hair Dye Penetration in Monkey and Man
Leszek J. Wolfram and Howard I. Maibach
Chapter 31 Percutaneous Absorption of Sunscreens
Heather A.E. Benson, Yousuf H. Mohammed, Kenneth A. Walters and Michael S. Roberts
Chapter 32 Sunscreen Percutaneous Penetration in Vivo in Man
Pranav Vasu and Howard Maibach
Chapter 33 Cutaneous Metabolism of Xenobiotics
Howard I. Maibach
Chapter 34 Chemical modification: an important and feasible method for improving peptide and protein dermal and transdermal delivery
Seyedeh Maryam Mortazavi, Hamid R. Moghimia, Howard I. Maibach
Chapter 35 Enchancing Percutaneous Penetration of Oligonucleotide Drugs
Howard I. Maibach and Myeong Jun Choi
Chapter 36 Use of Microemulsions for Topical Drug Delivery
Efrem N. Tessema, Sandra Heuschkel, Anuj Shukla, and Reinhard H. H. Neubert
Chapter 37 Transdermal Delivery of Vesicular Nanocarriers Under Electrical Potential
Ebtessam A. Essa , Gamal M. El Maghraby, Michael C. Bonner and Brian W. Barry
Chapter 38 Nanocarriers and physical methods
Nina Dragicevic
Chapter 39 Assessment of Microneedles for Transdermal Drug Delivery
Melissa Kirkby, Kurtis J. Moffatt, Aaron. R.J. Hutton, Inken Ramöeller, Peter E. McKenna, Marco T.A. Abbate, Sarah A. Stewart, Ryan F. Donnelly
Chapter 40 Clinical Testing of Microneedles for Transdermal Drug Delivery
Raja K. Sivamani, Gabriel C. Wu, Boris Stoeber, Dorian Liepmann, Hongbo Zhai and Howard I. Maibach
Chapter 41 Delivery of drugs, vaccines, and cosmeceuticals to skin using microneedle patches
Yasmine Gomaa and Mark R. Prausnitz
Chapter 42 Mirconeedle dermatotoxicology
Boen Wang
Chapter 43 Transdermal Transport by sonophoresis
Laurent Machet and Alain Boucaud
Chapter 44 Effect of Tape Stripping on Percutaneous Penetration and Topical Vaccination
Howard I.Maibach, Myeong Jun Choi and Harald Löffler
Chapter 45 Transcutaneous Delivery of Drugs by Electroporation
Shivakumar H Najappa, S.Narasimha Murthy
Chapter 46 IONTOPHORESIS IN PENETRATION ENHANCEMENT
Taís Gratieri, Yogeshvar N. Kalia
Chapter 47 VEHICLES AND TOPICAL THERAPY
Christian Surber
Chapter 48 The role of in vitro skin models in optimization of dermal drug delivery
Gøril Eide Flaten and Željka Vanić and Nataša Škalko-Basnet
Chapter 49 Effects of phospholipids on skin: use of primary human keratinocytes and fibroblasts as 2D cell culture models
Claudia Vater, Claudia Valenta, Victoria Klang
Chapter 50 Human cadaver skin viability for in vitro percutaneous absorption: storage and detrimental effects ...
Ronald C. Wester, Julie Christoffel, Tracy Hartway, Nicholas Poblete, Howard I. Maibach and James Forsell
Chapter 51 Determination of Percutaneous Absorption by In Vitro Techniques
Margaret E.K. Kraeling and Jeffrey J. Yourick
Chapter 52 Stripping Method for Measuring Percutaneous Absorption In Vivo
André Rougier, Claire Lotte, Howard I. Maibach
Chapter 53 Tape Stripping - Technique and Applications
Rebekka Christmann, Anne S. Raber, Ulrich F. Schaefer, Ana Melero and Brigitta Loretz
Chapter 54 Blood flow as technology in percutaneous absorption
Ethel Tur
Chapter 55 Confocal Raman Microspectroscopy in the assessment of skin barrier function and drug penetration
Jacqueline Resende de Azevedo, Yuri Dancik, Marie-Alexandrine Bolzinger, Stéphanie Briançon, Yves Chevalier
Chapter 56 Microscopy methods for assessing percutaneous drug penetration
Miko Yamada, Peter Hoffmann and Tarl Prow
Chapter 57 Dermal sampling techniques with focus on dermal Open Flow Microperfusion
Thomas Birngruber, Beate Boulgaropoulos, Frank Sinner
Chapter 58 Dermal-epidermal Separation Methods: Research Implications
Ying Zou
Chapter 59 Use of Skin Absorption Data in the Safety Evaluation of Cosmetic Ingredients
Jeffrey J. Yourick and Margaret E.K. Kraeling
Chapter 60 BIOEQUIVALENCE, PHARMACEUTICAL EQUIVALENCE AND BIOWAIVERS – TOPICAL DOSAGE FORMS FOR LOCAL ACTION
Isadore Kanfer
Chapter 61 In Vitro Human Nail Model To Evaluate Ungual Absorption and Transungual Delivery
Xaoying Hui, Howard I. Maibach
Chapter 62 Drug Permeation through Burn Eschar: Possibilities and Improvements
Hamid R. Moghimi, Seyedeh Maryam Mortazavi, Howard I. Maibach
Biography
Dr. Nina Dragićević is a professor in Pharmaceutical technology at the Department of Pharmacy at the Singidunum University in Belgrade, Serbia. She earned her master’s degree at the University of Belgrade, Faculty of Pharmacy, in 1999 and subsequently earned a Magister Degree and a PhD (summa cum laude, Dr. rer. nat.) in Pharmaceutical technology from the University of Belgrade and the Friedrich-Schiller University Jena, Germany, respectively. Before her employment at the University Singidunum, Dr. Dragićević worked as an accredited specialist in Pharmaceutical technology in the state pharmaceutical chain Apoteka "Beograd" in Belgrade. From 2007 to 2013 she was responsible for the preparation of compounded drugs for different routes of administration in pharmacies of Apoteka "Beograd", and in 2013 she was appointed director of the Production Department in the same company. She has published in a variety of international journals and she is editor of six books.
Professor Howard I. Maibach, Ph.D. is currently serving as Professor of Dermatology at the University of California, San Francisco. He earned his MD from Tulane University, New Orleans, LA in 1955. Later he served in faculty positions in various levels at the UCSF. Dr. Maibach has over 2,520 published manuscripts. He has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatological Society and the Internal Commission on Occupation Health.
"Understanding dermal absorption and developing mathematical models for absorption and dermal drug development is a complex process. This book is intended for scientists working in dermal absorption, degradation, and toxicities of drugs, cosmetics, and chemicals, who will find it informative. With a few new chapters, this book could be considered a comprehensive and updated reference. There are several books related to this subject matter in the marketplace, but each focuses on a particular area of the broader topic. Thus, this reference is a must-have in a library. "
- Rahmat M. Talukder, PhD, RPh(The University of Texas at Tyler)
Over the last three decades, vesicular phospholipid nanocarriers have been used successfully as tools to improve dermal and transdermal drug delivery as well as in the cosmetic field. The most common nanocarriers used for skin delivery are liposomes. However, since they have failed in efficiently delivering drugs across the intact skin, intensive research has been devoted to the development of new lipid vesicles that are capable of improving this process.
Invasomes represent a new class of vesicles, developed by introducing a mixture of terpenes and ethanol to the classic composition of liposomes, which have shown interesting results both in dermal and transdermal drug delivery.
The book “Invasomes as Drug Nanocarriers for Innovative Pharmaceutical Dosage Forms “ provides a comprehensive source of information for researchers from both academia and industry.
The first chapter deals the skin as a drug delivery route while the next chapter is a comprehensive overview on vesicular phospholipid nanocarriers. Then, the book content deals with preparation, characterization and evaluation of Invasomes, properly designed for delivering drugs and cosmetic active to the skin.
Overall, the book provides readers with comprehensive knowledge about these nanocarriers, since the author of the book is one of the main researchers in the field of Invasomes.- Professor Chiara Sinico, University of Cagliari-Italy
