1st Edition

Percutaneous Mitral Leaflet Repair
MitraClip Therapy for Mitral Regurgitation

ISBN 9781841849652
Published August 17, 2012 by CRC Press
182 Pages

USD $215.00

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Book Description

Mitral regurgitation (MR) affects millions of patients worldwide. It is a progressive condition that can worsen when left untreated, possibly leading to compensatory remodeling of the left ventricle. This can result in reduced functional capacity, poor quality of life, repeat hospitalizations, and even death from heart failure. Open, arrested heart surgery has until now been the therapeutic treatment of choice. However, many high-risk patients cannot tolerate traditional heart surgery and continue to suffer from severe MR.

In Percutaneous Mitral Leaflet Repair: MitraClip Therapy for Mitral Regurgitation, international experts discuss the clinical application of percutaneous mitral valve therapies for this subsect of patients, focusing on the MitraClip device. These new therapeutic developments will form an essential component of the interventional cardiologists’ armamentarium in treating MR patients and will be of interest to every practicing cardiologist.

Key topics include:

  • An overview of the anatomy and pathophysiology of the mitral valvular complex and MR
  • EVEREST trial outcomes, and the development of percutaneous edge-to-edge repair
  • Updates on the global experience with this new therapy
  • Patient selection and the role of percutaneous therapies for high-risk patients
  • Echocardiographic guidance, including practical tips for the use of transesophageal echocardiography during a procedure
  • Step-by-step techniques, plus tips and tricks for getting the best results for your patients
  • Special considerations for treating the returning MR repair patient
  • Discussion of the European experience since CE approval
  • Future directions in percutaneous mitral valve therapies


Table of Contents

Foreword - Mehmet Oz   
Foreword - Ferolyn T. Powell  
Preface - Alfieri Ottavio 

1. Anatomy of the Mitral Valvular Complex 
Nicolas M. Van Mieghem, Jackie S. McGhie, Margot M. Bartelings

2. The Pathophysiology of Mitral Regurgitation 
Blase A. Carabello

3. Genesis of the surgical edge-to-edge (E2E) repair 
Ottavio Alfieri, Michele De Bonis MD
4. Outcomes from surgical edge-to-edge repair 
Francesco Maisano

5. An overview of the literature on surgical mitral valve repair 
Sophie Jones, Michael Argenziano, Allan Schwartz

6. Development of Percutaneous Edge-to-Edge Repair: The MitraClip Story 
Frederick St Goar

7. MitraClip® System Design and History of Development 
Troy Thornton, Liz McDermott,

8. EVEREST Trial Results 
Alice Perlowski, Ted Feldman

9. Outcomes for Functional Mitral Regurgitation (FMR) 
James B Hermiller

10. The role of percutaneous mitral repair for high risk patients 
Patrick Whitlow    

11. Echocardiographic Evaluation for Mitral Regurgitation Grading and Patient Selection 
Ehrin J. Armstrong, Elyse Foster 

12. Understanding the Limits of Patient Selection for Edge-to-Edge Repair 
Jason Rogers, Ehrin J. Armstrong  

13. The basic technique for the Evalve MitraClip procedure 
Gretchen Gary, Ted Feldman 

14. Procedural tips & tricks 
Saibal Kar   

15. Training and simulation 
Scott Lim 

16. Special techniques for FMR 
Olaf Franzen   

17. The European experience since CE approval 
Corrado Tamborino, Gian Paolo Ussia, Valeria Cammalleri

18. An Interventionalist’s Approach to the Practical Use of TEE Guidance 
Howard C. Herrmann

19. Echo guidance 
Frank Silvestry   

20. A Critical Appraisal of Edge-To-Edge Repair with the MitraClip 
Peter C. Block

21. Technique for surgical removal of the MitraClip 
Michael Argenziano, Lori Soni 

22. Special considerations for MV repair after prior clip therapy 
Subhasis Chatterjeea, David A. Heimansohnb, John C. Alexandera

23. Gross and histologic findings after MitraClip placement 
Renu Vermani, Elena Ladich

24. Future directions in percutaneous mitral therapy 
Ted Feldman, Fred St. Goar 

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Ted Feldman, MD, FESC FACC FSCAI is director, Cardiac Catheterization Laboratory at NorthShore University Health System and Evanston Hospital, IL, USA. He has been a contributor to the development of percutaneous valve therapies, beginning with balloon valvuloplasty in the 1980s, and now with new methods for catheter-based valve repair and replacement.

Frederick St Goar, MD, FACC is an interventional cardiologist with Advanced Cardiovascular Specialists and a director of the Fogarty Institute for Innovation at El Camino Hospital, Mt View, CA, USA. He was the physician founder of Evalve.


" … offers a unique, comprehensive overview of transcatheter edge-to-edge repair … ."
—Volkmar Falk, MD, in CardioPulse