2nd Edition

Pharmaceutical Biotechnology

Edited By Michael J. Groves Copyright 2005
    428 Pages
    by CRC Press

    428 Pages
    by CRC Press

    Since the publication of the first edition of Pharmaceutical Biotechnology over a decade ago, a not-so-subtle shift in the meaning of the term "biotechnology" has occurred. It has come to mean something very specific, namely the development of drug substances with large protein and polypeptide molecules. These substances can be used as drugs in their own right but may also be used to manipulate cellular DNA in order to produce a required molecule that is believed to have desirable properties in the treatment of a disease. Accordingly, the second edition of this popular text reflects that change of definition by including new material that explores the development of these protein-based therapeutic substances.

    See what's new in the Second Edition:

  • Expanded coverage of the formulation of proteins
  • Additional information on proteins used as drug delivery systems
  • Detailed discussion of interactions between proteins and phospholipids
  • Increased information on proteomics and gene therapy
  • Exploration of pulmonary administration and oral delivery of proteins
  • A broad review of vaccines
  • Discussion of genetic engineering and genomics
  • Challenges and issues involved in the development and the production of a drug
  • Introduction. The Structure of Proteins. Recombinant DNA Basics. Monoclonal Antibodies. Proteomics: A New Emerging Area of Biotechnology. Commonly Used Analytical Techniques for Biotechnology Products. Proteins as Drug Delivery Systems. Formulation of Proteins and Peptides. Proteins and Phospholipids. Vaccines: Ancient Medicines to Modern Therapeutics. Pulmonary Drug Delivery System for Biomarcromolecule. Polymeric Systems for Oral Protein and Peptide Delivery. Regulatory and Compendial Issues. Some Challenges Relating to the future of Biopharmaceutical Technology.


    A pharmacist with a doctorate in chemical engineering, Dr. Groves has spent much of his career working in industry and academe. Now retired, his scientific interests include dispersed drug delivery systems and quality control issues for parenteral drug products. Editor or joint editor of a number of books, he has published 400 research papers, patents, reviews and book reviews. He is a Fellow of the Royal Pharmaceutical Society of Great Britain, the Institute of Biology and the American Association of Pharmaceutical Scientists.