Pharmaceutical Dosage Forms : Capsules book cover
1st Edition

Pharmaceutical Dosage Forms

ISBN 9781315111896
Published October 30, 2017 by CRC Press
435 Pages 25 Color & 198 B/W Illustrations

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Book Description

Pharmaceutical Dosage Forms: Capsules covers the development, composition, and manufacture of capsules. Despite the important role that capsules play in drug delivery and product development, few comprehensive texts on the science and technology of capsules have been available for the research and academic environments. This text addresses this gap, discussing how capsules provide unique capabilities and options for dosage form design and formulation.

Table of Contents

1. Advances in Capsule Formulation Development and Technology

[Larry L. Augsburger and Stephen W. Hoag]

2. An Introduction to Two-Piece Hard Capsules and Their Marketing Benefits

[Dennis Murachanian]

3. Hard Shell Capsules in Clinical Trials

[Moji Christianah Adeyeye and Amusa Adebayo]

4. Capsule Shell Manufacture

[Brian E. Jones, Fridrun Podczeck, and Paul Lukas]

5. Non-Gelatin-Based Capsules

[Sven Stegemann]

6. Hard Shell Capsule Filling Machines

[Donald K. Lightfoot]

7. Instrumented Automatic Capsule Filling Machines and Filling Machine Simulation

[Larry L. Augsburger and Vikas Moolchandani]

8. Dry-Fill Formulation and Filling Technology

[Pavan Heda, Vikas Agarwal, and Shailesh K. Singh]

9. Plug Formation

[Fridrun Podczeck]

10. Modeling Powder Filling during Encapsulation

[Ammar Khawam]

11. Scale-Up and Transfer of Hard Shell Formulations across Machine Types

[Larry L. Augsburger and Michael Levin]

12. Modified-Release Delivery Systems: Extended-Release Capsule Platform

[Reza Fassihi]

13. Analytical Testing and Evaluation of Capsules

[Stuart L. Cantor and Asish K. Dutta]

14. Rheological Aspects of Capsule Shell Excipients and the Manufacture of Encapsulated Formulations

[Lawrence H. Block]

15. Quality-by-Design (QbD) for Capsule Formulation and Process Development: Regulatory Science Relevance, Scientific Case Studies, and Future Challenges

[Huiquan Wu, Lin Xie, Stephen W. Hoag, Larry L. Augsburger, and Mansoor Khan]

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Larry Augsburger is an Emeritus Professor at the University of Maryland School of Pharmacy.

Stephen W. Hoag, Ph.D., is a Professor of Pharmaceutical Sciences at the University of Maryland, Baltimore.