Completely revised and updated, this third edition of Pharmaceutical Dosage Forms and Drug Delivery elucidates the basic principles of pharmaceutics, biopharmaceutics, dosage form design, and drug delivery – including emerging new biotechnology-based treatment modalities. The authors integrate aspects of physical pharmacy, chemistry, biology, and biopharmaceutics into drug delivery.
This book highlights the increased attention that the recent spectacular advances in gene therapy and nanotechnology have brought to dosage form design and drug delivery. With the expiration of older patents and generic competition, the biopharmaceutical industry is evolving faster than ever.
Apart from revising and updating existing chapters on the basic principles, this edition highlights the emerging emphasis on drug discovery, antibodies and antibody-drug conjugates as therapeutic moieties, individualized medicine including patient stratification strategies, targeted drug delivery, and the increasing role of modeling and simulation.
Although there are numerous books on pharmaceutics and dosage forms, most cover different areas of the discipline and do not provide an integrated approach. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors and professionals, saving their time and money.
Introduction: Drug Discovery. Drug Development and Regulatory Process. Pharmaceutical Considerations. Biopharmaceutical Considerations. Pharmacy Math and Statistics. Radiopharmaceuticals. Physicochemical Principles: Complexation and Protein Binding. Chemical Kinetics and Stability. Interfacial Phenomena. Disperse Systems. Surfactants and Micelles. Pharmaceutical Polymers. Rheology. Drug Delivery Systems. Targeted Drug Delivery. Dosage Forms: Suspensions. Emulsions. Solutions. Powders and Granules. Tablets. Capsules. Parenteral Dosage Forms. Semisolid Dosage Forms. Inserts, Implants, and Devices. Protein- and Peptide-Based Dosage Forms. Biotechnology-Based Dosage Forms. Answers. Index.