1st Edition

Pharmaceutical Powder ComPattion Technology

Edited By Goran Alderborn, Christer Nystrom Copyright 1995
    1016 Pages
    by CRC Press

    1014 Pages
    by CRC Press

    This unique reference examines the modern pharmaceutical compacting techniques used to form tablets out of powders-describing the physical structure of pharmaceutical compacts, the bonding phenomena that occur during powder compaction, and the compression mechanisms of pharmaceutical particles.

    Interparticulate Bonding Characteristics of Pharmaceutical Compacts

    Interparticulate Attraction Mechanisms, Claus Führer
    The Importance of Intermolecular Bonding Forces and the Concept of Bonding Surface Area, Christer Nyström and Per-Gunnar Karehill

    Characterization of the Compression Process

    Porosity-Pressure Functions, Petteri Paronen and Jukka Ilkka
    Force-Displacement and Network Measurements, Gert Ragnarsson
    Viscoelastic Models, Fritz Müller
    Application of Percolation Theory and Fractal Geometry to Tablet Compaction, Hans Leuenberger, Ruth Leu, and Jean-Daniel Bonny

    Characterization of Compact Properties

    Mechanical Strength, Peter N. Davies and J. Michael Newton
    Tablet Surface Area, N. Anthony Armstrong
    Rationale for and the Measurement of Tableting Indices, Everett N. Hiestand

    Material Properties of Importance for Powder Volume Reduction and Compact Strength

    Particle Dimensions, Göran Alderborn
    Mechanical Properties, Ray C. Rowe and Ron J. Roberts
    Granule Properties, Göran Alderborn and Martin Wikberg
    Modeling the Compression Behavior of Particle Assemblies from the Mechanical Properties of Individual Particles, Wendy C. Duncan-Hewitt

    Compaction Properties of Excipients and Powder Mixtures

    Materials for Direct Compaction, Gerald K. Bolhuis and Zak T. Chowhan
    Compaction Properties of Binary Mixtures, John T. Fell
    Lubricant Sensitivity, Gerad K. Bolhuis and Arne W. Hölzer
    The Development and Optimization of Tablet Formulations Using Mathematical Methods, Fridrun Podczeck

    Biography

    Göran Alderborn, Christer Nyström