Pharmaceutical Powder Compaction Technology: 2nd Edition (Hardback) book cover

Pharmaceutical Powder Compaction Technology

2nd Edition

Edited by Metin Çelik

CRC Press

344 pages | 205 B/W Illus.

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Hardback: 9781420089172
pub: 2011-08-22
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Description

Compaction of powder constituents—both active ingredient and excipients—is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application.

This unique reference covers:

  • The physical structure of pharmaceutical compacts
  • Bonding phenomena that occur during powder compaction
  • Compression mechanisms of pharmaceutical particles
  • Theories and basic principles of powder compaction

New topics include:

  • Compaction data analysis techniques
  • The migration of powder constituents into commercial manufacture
  • Instrumentation for compaction
  • Compaction functionality testing, which is likely to become a USP requirement
  • Design space for compaction
  • Metrics required for scalability in tablet compression
  • Interactive compaction and preformulation database for commonly used excipients

Table of Contents

THEORY OF COMPACTION

Intermolecular Bonding Forces: where materials and process come together

Graham Buckton

COMPACTION DATA ANALYSIS TECHNIQUES

Viscoelastic Models

Susan K. Lum

Application of Percolation Theory and Fractal Geometry to Tablet Compaction

Hans Leuenberger, Maxim Puchkov, Ruth Leu-Marseiler, Jean-Daniel Bonny, Michael N. Leuenberger

Post Compaction Data Analysis Techniques

Gary Bubb

INTRUMENTATION AND EQUIPMENT IN COMPACTION

Tablet Press Instrumentation in the Research and Development Environment

Gary Bubb

Advanced Compaction Research Equipment: Compaction Simulators

Colleen Ruegger, Metin Çelik

Compactability Functionality Test

Eșay Okutgen

ROLE OF COMPACTION IN THE FORMULATION AND PROCESS DEVELOPMENT OF TABLETTING

Compaction Properties of Directly Compressible Materials

Gerad K. Bolhuis, Hans de Waard

Lubrication Issues in Direct Compaction

Gerad K. Bolhuis, Arne W. Hölzer

Crystal Engineering and Particle Design for the Powder Compaction Process

Anant Paradka, Peter York

Compaction of Combination Products

Carl T. Allenspach, Erika A. Zannou

Quality by Design and Compression

Chris Balducci, Rosario LoBrutto, Alan Royce, James Cheney, Dong Xiang, Olivia Darmuzey, Hedinn Valthorsson

Expert Systems and Their Use in Pharmaceutical Applications

Metin Çelik

Press-To-Press Scalability and Transitioning Factors

Gary Bubb

About the Series

Drugs and the Pharmaceutical Sciences

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology