Pharmacological Effects of Ethanol on the Nervous System: 1st Edition (Hardback) book cover

Pharmacological Effects of Ethanol on the Nervous System

1st Edition

Edited by Richard A. Deitrich, V. Gene Erwin

CRC Press

480 pages

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Hardback: 9780849383892
pub: 1995-12-21
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This book dissects the effects of ethanol on the major neurotransmitter systems affected by ethanol and correlates these actions with the behavioral consequences. The subject is approached first from the perspective of the neurochemical system and the behaviors resulting from ethanol's effects on that system. The behaviors themselves are discussed in later chapters. Some older theories of the effects of ethanol such as the membrane fluidization hypothesis are evaluated in light of new and updated information. Fetal Alcohol Syndrome (FAS) as well as the structural damage in the brain by long term ethanol exposure are also discussed.


"This is an exciting, useful and affordable book. . . . The editors have done a remarkable job of assembling much of the molecular/cellular, behavioral and chemical aspects of ethanol into some 450 pages."

-Journal of Studies on Alcohol

Table of Contents

Introduction, R.A. Deitrich and V.G. Erwin

Overview, G. Koob

Section I: Effects of Ethanol at the Molecular/Cellular Level

Cell Membrane Structure, W.G. Wood, F. Schroeder, R.M. Adibhatla, U. Igbavboa, N.A. Avdulov

Calcium Channels, D. Mullikin-Kilpatrick and S.N. Treistman

Chloride Channels/GABA, S.J. Mihic and R. A. Harris

Glutamate Receptors, B. Tabakoff and P.L. Hoffman

Cholinergic Systems, A.C. Collins

Phosphorylation, K. T. Eggeman and M.D. Browning

G-Proteins, F.Y.G. Lee, Sr. and G.S. Wand

Adenosine, T.V. Dunwiddie

Neurotensin, V.G. Erwin

Peptides, G.R. Siggins, Z. Nie, P. Schweitzer, S. Madamba, S.J. Henriksen

Thyrotropin Releasing Hormone, T.J. McCown and G.R. Breese

Section II: Behavioral Effects of Ethanol

Ethanol Intake, H.H. Samson and C.W. Hodge

Initial Sensitivity, L.J. Draski and R.A. Deitrich

Acute Tolerance, A.D. Le and J.M. Mayer

Dependence and Withdrawal, P. Metten and J.C. Crabbe

Ethanol's Acute Effects on Thermoregulation: Mechanisms and Consequences, R. Alkana and A.D. Le

Section III: Toxicity of Ethanol in the Central Nervous System

Free Radicals, R. Nordmann and H. Rouach

Fetal Damage-Mechanisms, W.-J.A. Chen, S.E. Maier, and J.R. West

Structural Damage, M.E. Charness

Neurological Damage and Stroke, M.E. Hillbom

Fetal Damage-Behavior, H.C. Becker

About the Series

Handbooks in Pharmacology and Toxicology

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
MEDICAL / Toxicology
SCIENCE / Chemistry / General
SCIENCE / Life Sciences / Neuroscience