Pharmacology of Antimuscarinic Agents: 1st Edition (Hardback) book cover

Pharmacology of Antimuscarinic Agents

1st Edition

By Laszlo Gyermek

CRC Press

528 pages

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Hardback: 9780849385599
pub: 1997-11-25
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Description

The theoretical and practical significance of antimuscarinic drugs is more obvious today than ever before. Antimuscarinics have helped to explore the pathomechanisms of of Alzheimer's disease, and to treat the symptoms of Parkinson's, cardiovascular problems, gastrointestinal diseases, and even nerve gas poisoning. No other drug class can claim as long a history with so many therapeutic applications, yet the most significant developments in this broad chapter of pharmacology come from the discovery of different muscarinic receptor sites in the peripheral and central nervous system and from the availability of many new selective agents, notably antagonists, for these different receptor types.

Pharmacology of Antimuscarinic Agents, written by an expert in anesthesiology and drug research, focuses on the basic principles of antimuscarinic drugs, their therapeutic value, how they work, and what versions are now available in the U.S. and abroad. This is the first time in decades an author has reviewed historical and current literature to present a comprehensive, standard reference on the antimuscarinic family.

Table of Contents

Introduction

History

Nomenclature

Mechanism and Site of Action of Antimuscarinic Agents

Description and Classification of Acetylcholinergic Receptor Sites

The Role of ACh in Neuronal Conduction

Chemical Structural Aspects Related to Stimulation and Block of the ACh Receptors

The Tropane Alkaloids

Chemistry

Absorption, Distribution, Metabolism, and Elimination of Atropine and Related Tropane Alkaloids (Animal and Human Data)

Animal Pharmacology of Atropine

Resistance to Atropine

Hyosciamine

L (-) Hyoscine (Scopolamine) - Introduction

Atropine and L (-) Hyoscine as Pharmacologic Probes in the Pharmacologic Exploration of the CNS

Semisynthetic Derivatives of Tropane Alkaloids and Other Tropine Esters

N-Methylquaternary Derivatives of Tropane Alkaloids - Introduction

Other Tropeines

Synthetic Antimuscarinic Agents

Antimuscarinic Tropane Derivatives

Other Bicyclic and Polycyclic Amines

4-Acyloxy 2,6-Disubstituted Piperidines

Aliphatic and Alicyclic Aminoalcohol Esters of Aromatics Acids

1,3-Dioxolane Derivatives

Amino Alkanols and Amino Alkanes Substituted with Aromatic Groups

Aromatic Acid Amide and Nitrile Derivatives of Alkyl Amines

Aromatic Ether Derivatives of Amino Alkanols

Other Compounds of Various Chemical Structures with Antimuscarinic Properties

Synthetic Agents with Central Acetylcholinolytic Properties Used in Parkinson's Disease

Molecular Design of Antimuscarinic Agents

Muscarinic Receptor Subtype-Nonspecific Agents

Muscarinic Receptor Subtype-Specific Agents

Drug Interactions

Clinical Pharmacology and Therapeutic Uses of Antimuscarinic Agents

Pharmacokinetics

Effects on the Cardiovascular System in Man

Effects on Respiration

Effects on the Motor Functions of the Gastrointestinal and Genitourinary Tract

Action on Secretory Functions

Effects on the Eye

Effects of Antimuscarinics in the CNS

Clinical Studies with Other Antimuscarinic Agents and their Therapeutic Uses

Use of Antimuscarinic Agents as Adjuncts to Anesthesia

Use in Anticholinesterase Poisoning

Emesis and Motion Sickness

Use in Cerebral Injuries

Toxicity of Atropine

Toxicity in Animals

Toxicity in Man

Summary

References

Index

About the Series

Handbooks in Pharmacology and Toxicology

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED006000
MEDICAL / Anesthesiology
MED071000
MEDICAL / Pharmacology