Pharmacology of Cerebral Ischemia: 1st Edition (Hardback) book cover

Pharmacology of Cerebral Ischemia

1st Edition

Edited by Josef Krieglstein


541 pages

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Hardback: 9780849310218
pub: 2001-11-01
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Discussing state of the art techniques and the latest development in the field, Pharmacology of Cerebral Ischemia forges links between basic science and practical therapy.

Table of Contents

Apoptosis and Necrosis After Ischemia

Apoptosis and Neurodegeneration: Role of Caspases, P. Nicotera

Apurinic/Apyrimidinic Endonuclease Expression and Oxidative Stress in Apoptosis after Transient Focal Cerebral Ischemia, M. Fujimura, Y. Morita-Fujimura, M. Kawase, Y.-Y. Chang, and P.H. Chan

A Role for the Transcription Factor E2F1 in Experimental Stroke Damage, J.P. MacManus, S.T. Hou, M. Jian, E. Preston, J. Webster, and B, Zurakowski

Reactive Oxygen and Cytochrome C Release in Neuronal Apoptosis, R.A. Kirkland and J.L. Franklin

The Roles of Beta-Amyloid Percursor Protein and Amyloid Beta Peptide in Ischemic Brain Injury, B. Lin and M.D. Ginsberg

Receptors and Intracellular Signaling

A Possible Role for Tachykinins in Stroke, R.K. Stumm, C. Culmsee, C. Schaper, M.K.-H. Scafer, J. Krieglstein, and E. Weihe

New Insights into the Role of NMDA-Receptors and Nitric Oxide Formation in the Genesis of Spreading Depression, T.P. Obrenovitch

Imaging the Anoxic Depolarization, a Multifocal and Propagating Event, R.D. Andrew, T.R. Anderson, A.J. Biedermann, I. Joshi, and C.R. Jarvis

Protein Phosphatases and Neuronal Apoptosis, S. Klumpp, D. Selke, and J. Krieglstein

Role of Cyclin Dependent Kinases in Neuronal Death, D.S. Park

p21 ras/Erk-Dependent Signaling Activates Ischemic Tolerance, V.L. Dawson and T.M. Dawson

Neuroprotective Potency of Activated NF- B, C. Kaltschmidt and B. Kaltschmidt

NF- B is Activated and Promotes Cell Death in Focal Cerebral Ischemia, A. Schneider, A. Martin-Villalba, F. Weih, J. Vogel, T. Wirth, and M. Schwaniger

Caspases in Cerebral Ischemia, N. Plesnila and M.A. Moskowitz

Intrinsic and Extrinsic Pathways of Caspase Activation in Cerebral Ischemia, K. Jin, J. Chen, and R.P. Simon

Mechanisms of Neuronal Cell Injury: Does Endoplasmic Reticulum Dysfunction Play a Special Role? W. Paschen

Role of Mitochondria in Neuronal Cell Death

The Role of Mitochondrial Dysfunction in Reperfusion Damage of the Brain, B.K. Siesjö, T. Kristián, F. Shibasaki, and H. Uchino

Mitochondria as Targets of Neuroprotection by Bcl-2 Family Proteins, G. Fiskum, B.M. Polster, and A.J. Kowaltowski

Regulation of Active Cell Death in Ischemic Brain Injury: The Role of Bax and the Mitochondrial Pathway, J. Chen and X.M. Yin

The Effect of pH on State 3 and State 4 Brain Mitochondrial Metabolism, D.B. Kintner, K.A. Sailor, and D.D. Gilboe

Cytochrome C Release in Apoptotic and Excito-Toxic Neuron Death, J.H.M. Prehn, N.T. Bui, A.J. Krohn, C.M. Luetjens, M. Poppe, and C. Reimertz

Regulation of the Mitochondrial Permeability Transition Pore by Ubiquinone Analogs, P. Bernardi and E. Fontaine

Inflammation and Neuronal Cell Death

Do Caspase and Proteasome Inhibitors Influence the Delayed Maturation of Cortical Infarction by Preventing Apoptosis or Neuroinflammation? A.M. Buchan

Inflammation-Related Genes and Ischemic Brain Injury, C. Iadecola, M. Alexander, S. Nogawa, E. Araki, and M.E. Ross

Metalloproteinase Generation and Matrix Injury During Focal Cerebral Ischemia, G.J. del Zoppo, J. Lucero, N. Hosomi, and J.H. Heo

Inhibition of Inflammation and Neuroprotection by Tetracyclines, J. Yrjänjeikki, T. Tikka, G. Goldsteins, M. Koistinaho, R. Keinänen, P.H. Chan, and J. Koistinaho

Non-Neuronal Cells in the Injured Brain: Cellular Pathology and Molecular Activation Signals, G. Raivich

Ultrastructural Behavior of Astrocytes to Singly Dying Cortical Neurons, U.Ito, T. Kuroiwa, S. Hanyu, Y. Hakamata, S. Ito, I. Nakano, and K. Oyanagai


Dynamic Investigation of the Rat Cortical Microcirculation Using Confocal Videomicroscopy in Transient Focal Ischemia and Related Penumbral Depolarizations, H. Nallet, S. Roussel, O. Isseratial, E.T. MacKenzie, J. Seylaz, and E. Pinard

Cerebral Vasospasm of Penetrating Arteries in Brain Stem, A.Y. Zubkov and J.H. Zhang

Repair, Recovery, and Neuroprotection

DNA Damage and Repair in the Setting of Mild Injury, H.-M. Lee, G.H. Greeley,Jr., and E.W. Englander

Functional Recovery after Brain Injury: Role of Neurotrophic Factors and Behavior-Driven Structural Events, T. Schallert, S.T. Bland, and S.M. Fleming

Difference in the Time Windows for the Induction of Ischemic Tolerance: Putative Mechanisms, M.A. Pérez-Pinzón

The Neuroprotective Efficacy of Human Serum Albumin Therapy in Focal and Global Cerebral Ischemia and Traumatic Brain Injury, M.D. Ginsberg, L. Belayev, W. Zhao, Y.Liu, E. Pinard, J. Seylaz, H. Nallet, and R. Busto

Growth Factors and Cytokines

Update on Growth Factor Treatment for Stroke: 2000, S.P. Finklestein and K. Wada

Gene Transfer of GDNF Ameliorates Ischemic Rat Brain Injury after Transient MCA Occlusion, K. Abe, H. Kitagawa, and T. Hayashi

The Expression Pattern of TGF- 1 in Rat Hippocampus after Transient Forebrain Ischemia and after Stimulation of 2-Adrenoceptors, Y. Zhu and J. Kreiglstein

Modulation of the Serpine/Serine Proteases Axis by TGF- 1 is a Key Element in the Control of the Glutamatergic Neurotransmission, D. Vivien, C. Ali, O. Nicole, F. Docagne, and A, Buisson

Contextual Actions of TGF- and Cytkine Signaling Pathways in Mediating Neurotrophic Functions, N. Schuster, A. Schober, and K. Kreiglstein

Cytokines as Therapeutic Targets in Stroke, N.J. Rothwell

Inflammatory and Anti-Inflammatory Cytokines and Neuronal Cell Death, S.A. Loddick

Site-Specific Actions of Interleukin-1 in Neurodegeneration, S.M. Allen, L.C. Parker, R.I Grundy, and B. Collins

Genes and Gene Therapy

Expression Analysis and Functional Genomics for Brain Research: Expression Profiling in a Mouse Model for Huntington's Disease, W. Nietfeld, J. Schuchhardt, A. Malik, N. Tandon, E. Rohlfs, E.E. Wanker, H. Eickhoff, and H. Lehrach

High Throughput Transcript Profiling: An Assessment of SAGE in the Context of Stroke Research, G. Trendelenburg and U. Dirnagl

The Role of Gene Therapy in Acute Cerebral Ischemia, M.A. Yenari, T.C. Dumas, R.M. Sapolsky, G.K. Steinberg

Stem Cell Therapy and Neurogenesis

Neurogenesis and Synaptogenesis in Hippocampus Following Global Ischemia, R. Bernabeu, J. Liu, and F.R. Sharp

Treatment if Neural Injury with Bone Marrow, M. Chopp, Y. Li, and J. Chen

Harnessing Neural Stem Cell Biology to Compensate for Cerebral Ischemic Injury, K.I. Park, B.A. Tate, J.M. Ren, D. Sietsma, A. Marciniak, S.P. Finklestein, and E.Y. Snyder

Possible Transplantation Strategies in Stroke: Could Stem Cells be the Answer? C.N. Svendsen

Predictiveness of Animal Models for Clinical Trials

Translating Experimental Neuroprotection to Humans: Failure and Success, J. Grotta

Which Pathophysiologic Mechanisms are Relevant Therapeutic Targets in Ischemic Stroke? W.-D. Heiss, L.W. Kracht, A. Thiel, M. Grond, G. Pawlik, and R. Graf

Pathophysiology of Thrombolytic Reperfusion Versus Reversible Thread Occlusion of Middle Cerebral Artery in Mice, T. Hara, R. Hata, G. Miles, and K.-A. Hossmann

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Neurology
MEDICAL / Pharmacology