This two-volume text provides a summary of current studies relating to the use of photosensitizing agents in the diagnosis and therapy of cancer. This interesting work describes synthesis of new sensitizers, photochemical and photobiological properties of dyes currently used for photodynamic therapy, plus those being examined with a view toward providing therapeutic advantages. It contains results and methodology from leading experts on the use of porphyrins and other photosensitizers for detection of neoplastic disease and for photodynamic therapy of neoplastic disease. The volumes focus on the major clinical and pre-clinical research groups. They also include an appended bibliography which lists all pertinent publications in this field. This easy-to-understand book is written for all workers in the field of photodynamic therapy and provides an introduction to those beginning research on some aspect of tumor photosensitization.
VOLUME I: CLINICAL and PRE-CLINICAL STUDIES. Photodynamic Therapy for the Treatment of Cancer: Current Status and Advances. Clinical Experiences with PDT-A Five Year Study. Photodynamic Therapy of Neoplastic Disease. Urologic Use of Photodynamic Therapy. Fluorescence Diagnosis and Dosimetry Using Porphyrins. Optical Dosimetry in PDT. The Quantitative Determination of Porphyrins in Tissues and Body Fluids: Applications in Studies of Photodynamic Therapy. The Determination of Light Fluence Distributions for Photodynamic Therapy. Cellular and Tumor Model Studies Using Several Photodynamic Sensitizers. Probing the Effects of Photodynamic Therapy Through In Vivo-In Vitro Methods. Examination of In Vitro and In Vivo Photodamage Induced By Photodynamic Therapy. Effects of PDT on DNA and DNA-Related Cell Reactions. Photochemotherapy: Application of Photosensitized Reactions in the Treatment of Disease. Photosensitized Lipid Peroxidation in Biological Membranes. New Tetrapyrroles for Photodynamic Therapy. Relative Merits of Porphyrin and Phthalocyanine Sensitization for PDT. Phthalocyanines as Sensitizers for PDT of Cancer. Selective Photochemotherapy with Cationic Photosensitizers. Photosensitization of Malignant Gliomas with Cationic Lipophilic Dyes. Index.