This two-volume text provides a summary of studies relating to the use of photosensitizing agents in the diagnosis and therapy of cancer. This interesting work describes synthesis of new sensitizers, photochemical and photobiological properties of dyes currently used for photodynamic therapy, plus those being examined with a view toward providing therapeutic advantages. It contains results and methodology from leading experts on the use of porphyrins and other photosensitizers for detection of neoplastic disease and for photodynamic therapy of neoplastic disease. The volumes focus on the major clinical and pre-clinical research groups. They also include an appended bibliography which lists all pertinent publications in this field. This easy-to-understand book is written for all workers in the field of photodynamic therapy and provides an introduction to those beginning research on some aspect of tumor photosensitization.
LOCALIZATION. HPD: Structure and Determinants of Localization. Sites of Photodamage. The Relationship Between Porphyrin Transport and Tissue Uptake with Photosensitization From Singlet Oxygen. Binding of Photodynamic Photosensitizers to Human Plasma Studied By Ultracentrifugation. Localization Phenomena: pH Effects. Selective Localization of Photosensitizers in Tumors: A Review of the Phenomenon and Possible Mechanisms. Subcellular Sites of Photosensitization. Strategies for Tumor Targeting by Photodynamic Sensitizers. The Chemistry Associated with HPD. Porphyrin Chemistry. Meso-Tetra (Hydroxyphenyl) Porphyrins. The Triplet State and Singlet Oxygen Generation. Lifetime Measurements of Photosensitizers. Porphyrin Binding and Aggregation. Index.