Photostability of Drugs and Drug Formulations: 2nd Edition (Hardback) book cover

Photostability of Drugs and Drug Formulations

2nd Edition

Edited by Hanne Hjorth Tonnesen

CRC Press

448 pages | 172 B/W Illus.

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Hardback: 9780415303231
pub: 2004-06-29
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Description

Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource.

The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results.

Features

  • Assists non-experts in this field design a test protocol and interpret the results

  • Covers in vitro and in vivo aspects of interactions between drugs and light

  • Explores the kinetic and chemical aspects of drug photodecomposition

  • Discusses the problems frequently encountered in photochemical stability testing

  • Provides guidance on how to address photosafety assessments and labeling requirements of potentially photoreactive drugs

  • Highlights the practical implications of drug photodecomposition from a pharmaceutical viewpoint

  • Offers specific guidance in photostability testing and screening of drug photoreactivity
  • Table of Contents

    Introduction: Photostability Testing of Drugs and Drug Formulations - Why and How? H. Hjorth Tønnesen

    Photophysical and Photochemical Aspects of Drug Stability, D.E. Moore

    Standardization of Kinetic Studies of Photodegradation Reactions, D.E. Moore

    Rationalizing the Photochemistry of Drugs, A. Albini and E. Fasani

    Technical Requirements and Equipment for Photostability Testing, J. Boxhammer and A. Schönlein

    Photostability Testing: Design and Interpretation of Tests on New Drug Substances and Dosage Forms, N.H. Anderson and S.J. Byard

    The Questions Most Frequently Asked, H. Hjorth Tønnesen and S.W. Baertschi

    Inconsistencies and Deficiencies Which Exist in the Current Official Regulations Concerning the Photolytic Degradation of Drugs, J.C. Hung

    Benefits and Adverse Effects from the Combination of Drugs and Light, J. Moan and P. Juzenas

    In Vitro Screening of the Photoreactivity of Antimalarials. A Test Case, H.Hjorth Tønnesen and S. Kristensen

    Screening of Dyes, Drugs and Dietary Supplements for Ocular Phototoxicity, J.E. Roberts

    Photochemical and Photophysical Methods Used in the Study of Drug Photoreactivity, S. Navaratnam

    Addressing the Problem of Light Instability During Formulation Development, D.R. Merrifield, P.L. Carter, D. Clapham, and F.D. Sanderson

    Photostability of Parenteral Products, S. Kristensen

    Photoactivated Drugs and Drug Formulations, J. Karlsen and H . Hjorth Tønnesen

    Formulation Approaches for Improving Solubility and its Impact on Drug Photostability, H.Hjorth Tønnesen

    Appendix 1: Useful Terms and Expressions in the Photoreactivity Testing of Drugs

    Appendix 2: Relevant Literature on the Photostability of Specific Drug Substances and Drug Formulations

    Subject Categories

    BISAC Subject Codes/Headings:
    MED071000
    MEDICAL / Pharmacology