Phylogenomics: A Primer (Paperback) book cover


A Primer

By Rob DeSalle, Jeffrey Rosenfeld

© 2009 – Garland Science

352 pages | 160 Color Illus.

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Paperback: 9780815342113
pub: 2012-12-18
eBook (VitalSource) : 9781135038717
pub: 2012-12-01
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Phylogenomics: A Primer is for advanced undergraduate and graduate biology students studying molecular biology, comparative biology, evolution, genomics, and biodiversity. It

explores the origins of organic life on the planet, examines the use of scientific databases to understand the function of proteins within organisms, and provides insight into the interpretation of linear sequence information in the context of organismal change. This book explains the essential concepts underlying the storage and manipulation of genomics level data, construction of phylogenetic trees, population genetics, natural selection, the

tree of life, DNA barcoding, and metagenomics. The inclusion of problem-solving exercises in each chapter provides students with a solid grasp of the important molecular and evolutionary questions facing modern biologists as well as the tools needed to answer them. Online exercises are also available to assist students in working with the programs and databases used to analyze phylogenomic data.

Table of Contents

1. Why Phylogenomics Matters

2. The Biology of Linear Molecules: DNA and Proteins

3. Evolutionary Principles: Populations and Trees

4. Databases

5. Homology and Pairwise Alignment

6. Multiple Alignments and Constructing Phylogenomic Matrices

7. Genome Sequencing and Annotation

8. Tree Building

9. Robustness and Rate Heterogeneity in Phylogenomics

10. A Beginner's Guide to Bayesian Approaches in Evolution 11. Incongruence

12. Adapting Population Genetics to Genomics

13. Detecting Natural Selection in Genomes – Part 1

14. Detecting Natural Selection in Genomes – Part 2

15. Advanced Population Genetics Topics

16. Genome Content Analysis

17. A Phylogenomic Perspective of Biological Diversity: Tree of Life, DNA Barcoding and Metagenomics

18. Microarrays in Evolutionary Studies and Functional Phylogenomics

Subject Categories

BISAC Subject Codes/Headings:
COMPUTERS / Computer Science
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / Evolution
SCIENCE / Life Sciences / Genetics & Genomics
SCIENCE / Life Sciences / Biology / Molecular Biology