The Present book is aimed at providing a readable account of physical methods and results required to measure cell adhesion and interpret experimental data. Since on the one hand readability seemed a major quality for a book, and on the other hand, the problems posed referred to a wide range of domains of physics, chemistry, and biology, completeness had to sacrificed. Indeed, a whole book would not suffice to quote the relevant literature (and many more authors would be required to have read it). Hence, only a limited number of topics were selected for reliability of methods, availability of enough experimental results to illustrate basic conception or potential use in the future. These were discussed in three sections.
Section 1: Basic Physical Background 1. Intermolecular Forces 2. Model Polymers at Interfaces 3. Surface Physics and Cell Adhesion 4. Mechanics of Cell Deformation and Cell-Surface Adhesion Section 2: Selected Experimental Methods and Results 5. Use of Hydrodynamic Flows to Study Cell Adhesion 6. Use of Flow Cytometry in the Study of Intercellular Aggregation 7. Micropipette Studies of Cell and Vesicle Adhesion 8. Electron Microscopic Study of the Surface Topography of Isolated and Adherent Cells Section 3: Results and Models 9. The Data on Cell Adhesion 10. Models of Cell Adhesion Involving specific Binding