1st Edition
Phytomedicine and Alzheimer’s Disease
Alzheimer's disease, one of the most rapidly growing neurodegenerative disorders, is characterized by a progressive loss of memory. Despite several advances in the field of medical therapeutics, a viable treatment for Alzheimer's disease would be of great importance. Medicinal plants represent a largely untapped reservoir of natural medicines and potential sources of anti-Alzheimer’s drugs. The structural diversity of their phytoconstituents makes these plants a valuable source of novel lead compounds in the quest for drugs to treat Alzheimer's disease. Based on traditional literature and up-to-date research, various new therapeutically active compounds have been identified from phytoextracts, which could be useful in the treatment of cognitive disorders.
Phytomedicine and Alzheimer’s Disease presents information on
- Mechanistic aspects of neurodegeneration in Alzheimer’s disease and the role of phytochemicals as restorative agents
- Understanding the complex biochemical aspects of Alzheimer’s disease
- Pre-clinical approaches to evaluating drugs to target Alzheimer’s disease
- Assessing alternative approaches to treating Alzheimer’s disease and the role of alternative medicine to delay the symptomatic progression of this disease
- Epigenetic changes in Alzheimer’s disease and possible therapeutic or dietary interventions
This book serves as an excellent resource for scientific investigators, academics, biochemists, botanists, and alternative medicine practitioners who work to advance the role of phytomedicines in treating Alzheimer’s disease.
Preface
Acknowledgment
Editors
List of Contributors
Chapter 1 Annonaceae Species: A Perspective for Developing Phytomedicines for Alzheimer’s Disease
Chistiane Mendes Feitosa, Antônia Laires da Silva Santos, Alyandra de Sousa Nascimento, Veruska Cavalcanti Barros, Valeria Lima Silva Veras, and Mahendra Rai
Chapter 2 An Alternative Approach for Anti-Alzheimer’s Compounds from Plant Extracts
G. K. Pratap and Manjula Shantaram
Chapter 3 Phytotherapeutic Potential For the Treatment of Alzheimer’s Disease
Muhammad Akram, Atanu Bhattacharjee, Naveed Munir, Naheed Akhter, Fozia Anjum, Abida Parveen, Samreen Gul Khan, Muhammad Daniyal, Muhammad Riaz, Fahad Said Khan, Rumaisa Ansari, and Umme Laila
Chapter 4 Cognitive Improvement, Neuroprotective, and Nootropic Effect of Medhya Rasayana Drugs in Alzheimer’s Disease
Rinki Kumari, Jasmit Singh, Bhargawi Mishra, Anamika Tiwari, and Abaidya Nath Singh
Chapter 5 Prevention and Treatment of Alzheimer’s Disease in the Light of Ayurveda
Vinayak Majhi, Bishnu Choudhury, and Sudip Paul
Chapter 6 Medha Rasayana Plants: Ayurvedic Approach to Alzheimer’s Disease
Atanu Bhattacharjee and Biplab Kumar Dey
Chapter 7 Ethnomedicinal Plants Used By The Tribes Of Northeast India To Treat Alzheimer’s Disease
Bapi Ray Sarkar
Chapter 8 Neuroprotective Role of Resveratrol in Alzheimer’s Disease
V. S. Dendi and Magisetty Obulesu
Chapter 9 Pre-Clinical In-Vivo and In-Vitro Methods For Evaluation of Anti-Alzheimer’s Drugs
Shilpa A. Deshpande and Niraj S. Vyawahare
Chapter 10 Antioxidant Phytochemicals and Alzheimer’s Disease: Current Understanding and Future Scope
Saikat Sen, Raja Chakraborty, and Atanu Bhattacharjee
Chapter 11 Neuroprotective Role of Curcumin in Alzheimer’s Disease
Magisetty Obulesu and B. Mahendran
Chapter 12 Epigenetic Alterations in Alzheimer’s Disease and Its Therapeutic and Dietary Interventions
P. M. Aswathy, C. M. Shafeeque, and Moinak Banerjee
Chapter 13 Mechanistic Aspects of Neurodegeneration in Alzheimer’s Disease and the Role of Phytochemicals as Restorative Agents
Anindita Kundu, Vivekananda Mandal, Sujata Wangkheirakpam, and Subhash C. Mandal
Chapter 14 Pre-Clinical Approaches and Methods on Alzheimer’s Disease: In Vivo and In Vitro
S. R. Chandra and Pooja Mailankody
Chapter 15 Ethanolic Extracts of Dysphania ambrosioides Alleviates Scopolamine-Induced Amnesia in Experimental Animals
Rajashri Bezbaruah, Chandana C. Barua, Lipika Buragohain,Pobitra Borah, Iswar Chandra Barua, and Ghanshyam Panigrahi
Chapter 16 Neuroprotective Role of Quercetin in Alzheimer’s Disease
Magisetty Obulesu
Chapter 17 Plant Alkaloids and Their Derivatives Relevant to Alzheimer’s Disease
Atanu Bhattacharjee and Akula Ramakrishna
Chapter 18 Epigallocatechin-3-Gallate in Alzheimer’s Disease
Khaleel Pasha Md and Magisetty Obulesu
Chapter 19 β-Secretase (BACE1) Inhibitors From Natural Products
Atanu Bhattacharjee
Chapter 20 Carotenoids in Alzheimer’s Disease
Magisetty Obulesu
Index
Biography
Atanu Bhattacharjee, Akula Ramakrishna, M. Obulesu
"The organization and structure of the book are outstanding features. The chapter contents are clearly labeled, and the use of shorter topics makes the book easily accessible. This is a useful resource for researchers looking for up-to-date information validating the use of phytomedicine as a potential treatment for Alzheimer's disease. The book includes relevant discussions of mechanisms of action, biochemistry, and pathophysiology."
— Paul Joseph Ratte, Northwestern Health Sciences University
