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Pneumocystis Pneumonia book cover

3rd Edition

Pneumocystis Pneumonia

Edited By Peter Walzer, Melanie T. Cushion Copyright 2004
    760 Pages
    by CRC Press

    Continuing to serve as the definitive source on the subject, Pneumocystis Pneumonia offers a detailed update on the biology, pathogenesis, genetics, and immunology of Pneumocystis. This reference offers invaluable research and previously unpublished findings, and provides in-depth reviews on the development of new drugs, insights into host-pathogen interactions, emerging diagnostic techniques, global perspectives of the infection, future directions in the field, and more. This volume also provides a discussion of the genetic diversity of the disease in the context of nomenclature and recognition of species and molecular typing as well as description of the ongoing genome project.

    Part One THE ORGANISM 1. Historical Overview 2. Nomenclature and Genetic Variation of Pneumocystis 3. Pneumocystis Cellular Structure 4. Surface Antigens 5. Signal Transduction and Cellular Communication 6. Transmission and Epidemiology 7. Pneumocystis Genome Project and Genomic Organization Part Two HOST DEFENSES/INTERACTION WITH THE HOST 8. The Neonatal Period 9. Interactions of Pneumocystis with Alveolar Macrophages and Epithelial Cells 10. T Cells in Defense Against Pneumocystis 11. Cytokines 12. The Role of Humoral Immunity in the Defense Against Pneumocystis 13. The Pulmonary Surfactant System in Pneumocystis Pneumonia 14. Mechanisms of Lung Injury During Pneumocystis Pneumonia Part Three INFECTION IN HUMANS 15. Clinical Presentation and Diagnosis of Pneumocystis Pneumonia in HIV-Infected Patients 16. Pneumocystis Pneumonitis in Non-HIV-Infected Patients: Update 17. Pneumocystis jirovecii Pneumonia in AIDS Patients in the Developing World 18. Immunological Features of Pneumocystis Infection in Humans 19. Molecular Typing and Epidemiological Insights 20. Current Regimens for Treatment and Prophylaxis of Pneumocystis jirovecii Pneumonia 21. Lipids 22. Polyamines, Iron, and Pneumocystis carinii 23. DHFR and IMPDH: Enzymes Exploitable as Drug Targets in Pneumocystis 24. Dihydropteroate Synthase and Cytochrome B: The Problem of Emerging Resistance 25. Development of Candidate Anti-Pneumocystis Drugs: In Vitro and In Vivo Approaches

    Biography

    Peter D. Walzer Cincinnati Veterans Affairs Medical Center and University of Cincinnati College of Medicine Cincinnati , Ohio, U.S.A. Melanie T. Cushion Cincinnati Veterans Affairs Medical Center and University of Cincinnati College of Medicine Cincinnati , Ohio, U.S.A.

    "…a comprehensive and invaluable resource for information on the scientific aspects of the study of these remarkable fungi, as well as the clinical issues relevant to Pneumocystis infection. The editors are to be congratulated for assembling the expert team that has produced this solid body of information."
    -Clinical Infectious Diseases

    "…the most comprehensive source of data in the fast evolving field of P carinii infection….it is the reference book on pneumocystis."
    The Journal of Clinical Pathology
    "…a highly recommended treatise for all medical libraries."
    AIDS Book Review Journal


    "…the most comprehensive source of data in the fast evolving field of P carinii infection….it is the reference book on pneumocystis."
    The Journal of Clinical Pathology
    "…a highly recommended treatise for all medical libraries."
    AIDS Book Review Journal
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