Polymer and Polymer-Hybrid Nanoparticles: From Synthesis to Biomedical Applications, 1st Edition (Hardback) book cover

Polymer and Polymer-Hybrid Nanoparticles

From Synthesis to Biomedical Applications, 1st Edition

By Stanislav Rangelov, Asterios Pispas

CRC Press

499 pages | 263 B/W Illus.

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Description

Polymeric and hybrid nanoparticles have received increased scientific interest in terms of basic research as well as commercial applications, promising a variety of uses for nanostructures in fields including bionanotechnology and medicine. Condensing the relevant research into a comprehensive reference, Polymer and Polymer-Hybrid Nanoparticles: From Synthesis to Biomedical Applications covers an array of topics from synthetic procedures and macromolecular design to possible biomedical applications of nanoparticles and materials based on original and unique polymers.

The book presents a well-rounded picture of objects ranging from simple polymeric micelles to complex hybrid polymer-based nanostructures, detailing synthetic procedures, techniques for characterization and analysis, properties, and behavior in selective solvents and dispersions. Each chapter contains background and introductory information, summarizing generalities on the nanosystems being discussed. The chapters also describe representative works of experts and provide in-depth, focused discussions.

The authors present current knowledge on the following topics:

  • Designed synthesis of functional polymers
  • Construction of block copolymer micellar and nonmicellar self-assembled structures
  • Construction of organic–organic hybrid nanosized particles
  • Construction of organic–inorganic hybrid nanoparticles and nanoassemblies

The final chapter addresses biological applications of polymeric nanoparticles, including delivery of low-molecular-weight drugs, macromolecular drugs, imaging and diagnostics, and photodynamic therapy. Summarizing important developments in the field, the authors condense relevant research into a comprehensive resource.

Table of Contents

Polymer Synthesis

Introduction

Generalities on Living/Controlled Polymerizations

Block Copolymers

Heterogeneous Polymerization Techniques for Polymeric Nanoparticle Synthesis

References

Polymeric Nanoparticles from Pure Block Copolymers

General Aspects of Copolymer Self-Assembly

Self-Assembled Polymeric Aggregates: From Micelles to Vesicles and More Complex Structures

References

Organic–Organic Hybrid Nanoassemblies

Introductory Notes

Polymer–Surfactant Hybrid Structures

Polymer–Lipid Hybrid Structures

Polymer–Polymer Hybrid Structures

Hybrid Structures Formed upon Interaction of Polymers with Proteins and Peptides

Hybrid Structures Formed upon Interactions of Polymers with Oligo- and Polynucleotides

References

Hybrid Polymeric Nanoparticles Containing Inorganic Nanostructures

Introduction

Some General Features of Inorganic Nanoparticles

Polymers as Ligands for Nanoparticle Formation and Stabilization

Synthesis of Inorganic Nanoparticles in Block Copolymer Micelles and Other Polymeric Nanostructures in Solutions

Hybrid Nanostructures from Preformed Inorganic Nanoparticles and Block Copolymers

Hybrid Polymersomes

Surface-Modified Inorganic Nanoparticles by Grafted Polymer Chains

Hybrid Polymeric Nanoparticles via (Mini)Emulsion Polymerization

Hybrid Nanoparticles by LbL Approaches and Hybrid Polymeric (Polyelectrolyte) Nanocapsules

Hybrid Nanoparticles Incorporating Block Copolymers and Carbon Nanomaterials

References

Biological Applications of Polymeric Nanoparticles

Delivery of Low-Molecular-Weight Drugs

Delivery of Macromolecular Drugs

Applications in Imaging and Diagnostics

Polymeric Nanoparticles for Photodynamic Therapy

Multifunctional Polymeric Nanoparticles

References

Index

About the Authors

Stanislav Rangelov, Ph.D., has served as an associate professor at the Institute of Polymers, Bulgarian Academy of Sciences, Sofia, since 2005 and as a full professor since 2011. Presently, he serves as head of the Laboratory of Polymerization Processes and chair of the Scientific Council of the Institute of Polymers. His research interests include controlled polymerization processes, self-assembly of amphiphilic copolymers, and polymer and polymer–hybrid nanosized particles.

Stergios Pispas, Ph.D., has served as a senior researcher at the Theoretical and Physical Chemistry Institute of theNational Hellenic Research Foundation (TPCI-NHRF), Athens, Greece, since 2009. He also served as editor of the European Physical Journal E (2003–2012). Dr. Pispas received the American Institute of Chemists Foundation Award (1995) and the ACS A. K. Doolittle Award (2003). His current research focuses on the synthesis of functional block copolymers and polyelectrolytes, as well as the study of complex, self-organized, "hybrid" nanosystems based on polymers and surfactants, biomacromolecules, and inorganic nanomaterials.

Subject Categories

BISAC Subject Codes/Headings:
SCI010000
SCIENCE / Biotechnology
TEC021000
TECHNOLOGY & ENGINEERING / Material Science
TEC055000
TECHNOLOGY & ENGINEERING / Textiles & Polymers