2 Volume Set, Third Edition
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Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials: from their chemical, physical, and structural properties to current applications in the medical and pharmaceutical fields.
The book is organized into two volumes containing 53 authoritative chapters written by experts from around the world. The first volume, Polymeric Biomaterials: Structure and Function, contains information about the structure and properties of synthetic polymers including polyesters, polyphosphazenes, and elastomers and natural polymers such as mucoadhesives, chitin, lignin, and carbohydrate derivatives. It also describes their blends or composites—for example, metal–polymer composites and biodegradable polymeric/ceramic composites—as well as drug carriers and delivery systems, gene and nucleic acids delivery, and polymer synthesis and processing techniques.
The second volume, Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, addresses processing of polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for various uses in the medical and pharmaceutical arenas. The chapters address numerous medical issues including pulmonary disease, cancer, heart disease, tissue damage, and bone disease. The applications covered include a variety of drug delivery systems, medical devices, anticancer therapies, biological uses for hydrogels, nanotechnology, bioartificial organs, and tissue engineering. This third edition set presents new and substantially revised topics, providing a comprehensive reference of the latest developments and the most up-to-date applications of biomaterials in medicine.
Table of Contents
Volume 1: Synthesis and Fabrication of Polyesters as Biomaterials. Hydrogels Formed by Cross-Linked Poly(Vinyl Alcohol). Development and Evaluation of Poly(Vinyl Alcohol) Hydrogels as a Component of Hybrid Artificial Tissues for Orthopedics Surgery Application. Polyphosphazenes as Biomaterials. Biodegradable Polymers as Drug Carrier Systems. Bioresorbable Hybrid Membranes for Bone Regeneration. Mucoadhesive Polymers: Basics, Strategies, and Future Trends. Biodegradable Polymeric/Ceramic Composite Scaffolds to Regenerate Bone Tissue. Amphiphilic Systems as Biomaterials Based on Chitin, Chitosan, and Their Derivatives. Biomaterials of Natural Origin in Regenerative Medicine. Natural Polymers as Components of Blends for Biomedical Applications. Metal–Polymer Composite Biomaterials. Evolution of Current and Future Concepts of Biocompatibility Testing. Biocompatibility of Elastomers. Preparation and Applications of Modulated Surface Energy Biomaterials. Electrospinning for Regenerative Medicine. Polymeric Nanoparticles for Targeted Delivery of Bioactive Agents and Drugs. Polymeric Materials Obtained through Biocatalysis. Polymer-Based Colloidal Aggregates as a New Class of Drug Delivery Systems. Photoresponsive Polymers for Control of Cell Bioassay Systems. Lignin in Biological Systems. Carbohydrate-Derived Self-Crosslinkable In Situ Gelable Hydrogels for Modulation of Wound Healing. Dental and Maxillofacial Surgery Applications of Polymers. Biomaterials as Platforms for Topical Administration of Therapeutic Agents in Cutaneous Wound Healing. Polymers for Artificial Joints. Volume 2: Antithrombin–Heparin Complexes. Glucose-Sensitive Hydrogels. Advances in Polymeric and Lipid-Core Micelles as Drug Delivery Systems. Modular Biomimetic Drug Delivery Systems. Polymeric Nanoparticles for Drug Delivery. Drug Carrier Systems for Anticancer Agents. Application of Polymer Drugs to Medical Devices and Preparative Medicine. Polymer Implants for Intratumoral Drug Delivery and Cancer Therapy. Biological Stimulus-Responsive Hydrogels. Polymeric Materials for Surface Modification of Living Cells. Biomedical Applications of Shape Memory Polymers and Their Nanocomposites. Bioadhesive Drug Delivery Systems. Nanomedicines Coming of Age. Polymers for Myocardial Tissue Engineering. Acellular Tubular Grafts Constructed from Natural Materials in Vascular Tissue Engineering. pH-Responsive Polymers for Delivery of Nucleic Acid Therapeutics. Adhesive Biomaterials for Tissue Repair and Reconstruction. Polymeric Interactions with Drugs and Excipients. Manufacturing Multifunctional Scaffolds for Tissue Engineering. Virus-Based Nanoparticles as Drug Delivery Systems. Polymeric Biomaterials in Pulmonary Drug Delivery. Polymeric Gene Delivery Carriers for Pulmonary Diseases. Biomedical Application of Membranes in Bioartificial Organs and Tissue Engineering. Controlled Release Systems for Bone Regeneration. Controlled Release Systems Targeting Angiogenesis. Bioceramics for Development of Bioartificial Liver. Materials Biofunctionalization for Tissue Regeneration. Polymers-Based Devices for Dermal and Transdermal Delivery.
Severian Dumitriu (deceased) was a research professor in the Department of Chemical Engineering at the University of Sherbrooke, Quebec, Canada. He edited several books, including Polymeric Biomaterials, Second Edition, Polysaccharides in Medicinal Applications, and Polysaccharides: Structural Diversity and Functional Versatility. He also authored or coauthored more than 190 professional papers and book chapters in the fields of polymer and cellulose chemistry, polyfunctional initiators, and bioactive polymers and held 15 international patents. Professor Dumitriu received his BSc (1959) and MS (1961) in chemical engineering and his Ph.D. (1971) in macromolecular chemistry from the Polytechnic Institute of Jassy, Romania.
Valentin I. Popa earned his BSc and MSc in chemical engineering (1969) and Ph.D. in the field of polysaccharide chemistry (1976) from Polytechnic Institute of Iasi, Romania. He was awarded the Romanian Academy Prize for his contributions in the field of seaweed chemistry (1976). He has published more than 500 papers in the following fields: wood chemistry and biotechnology, biomass complex processing, biosynthesis and biodegradation of natural compounds, allelochemicals, bioadhesives, and bioremediation. Dr Popa is also the author or coauthor of 37 books or book chapters. He holds six patents and has been involved in many Romanian and European research projects as scientific manager. He is also a professor of wood chemistry and biotechnology at "Gheorghe Asachi" Technical University of Iasi, and editor-in-chief of Cellulose Chemistry and Technology.
"This third edition set is a versatile and comprehensive book, presenting new and substantially revised topics, and combining the basic fundamentals of the field of biomaterials with the industrial applications. Thus, the book is a very useful tool for scientists, engineers, pharmacists and other experts from different disciplines, as well as for teachers, graduate and undergraduate students interested in this area."
—Diana Ciolacu, Cellulose Chem. Technol., 47 (5-6), 487-494 (2013)