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Polymeric Gene Delivery
Principles and Applications




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ISBN 9780849319341
Published September 29, 2004 by CRC Press
704 Pages - 15 Color & 291 B/W Illustrations

 
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Book Description

To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry, and limited scale of industrial production.

Polymeric Gene Delivery: Principles and Applications is the first comprehensive book to specifically address polymeric gene delivery systems. Uniting the expertise of international academic and industrial scientists who are working in the area of polymeric vectors for gene delivery, it is written by prominent researchers directly involved in this field. The book is divided into five sections that deal with challenges and opportunities in gene delivery and the efficient delivery of genes into somatic cells using polymeric vectors. The authors discuss using biodegradable polymers, condensing and non-condensing polymeric systems, microspheres and nanospheres, and designing specialized delivery systems based on targeting strategies.

Polymeric Gene Delivery: Principles and Applications accentuates the versatility of polymeric delivery systems, including the potential for biocompatibility, the ability to design their formulation and geometry for a specific purpose, and the ease of modification to the surface of polymeric carriers. This book is an up-to-date guide for researchers in the field and those interested in entering this dynamic field.

Table of Contents

Introduction; Robert Langer, MIT, Cambridge, MA

GENE DELIVERY: CHALLENGES AND OPPORTUNITIES
Tissue and Cell Specific Targeting for the Delivery of Genetic Information; Randall J. Mrsny, University of Wales, UK
Biological Barriers to Gene Transfer; Yasufumi Kaneda, Osaka University, Japan
Cellular Uptake and Trafficking; Sujatha Dokka and Yon Rojanasakul, West Virginia University. Morgantown, WV, USA
Pharmacokinetics of Polymer/Plasmid DNA Complex; Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida, Kyoto University, Japan

CONDENSING POLYMERIC SYSTEMS
A. Non-Degradable Polymers
Poly(L-Lysine) and Copolymers for Gene Delivery; Minhyung Lee and Sung Wan Kim, University of Utah, Salt Lake City, USA
Gene Delivery Using Polyethyleneimine and Copolymers; Manfred Ogris, Centre of Drug Research, LMU Munich, Germany
Chapter 8. Poly(2-(Dimethylamino)Ethyl Methacrylate)-Based Polymers for the Delivery of Genes In Vitro and In Vivo; .J. Verbaan, D.J.A. Crommelin, W.E. Hennink, and G. Storm, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
Cationic Dendrimers as Gene Transfection Vectors; Lori A. Kubasiak and Donald A. Tomalia, Dendritic Nanotechnologies, Inc., Mt. Pleasant, MI
Poly(ethylene glycol)-Conjugated Cationic Dendrimers; Joon Sig Choi, Tae-il Kim, and Jong-Sang Park, Seoul National University, Korea
Water Soluble Lipopolymers for Gene Delivery; Ram I. Mahato, University of Tennessee Health Science Center, Memphis, and Sung Wan Kim, University of Utah, Salt Lake City, USA
Cyclodextrin-Containing Polymers for Gene Delivery; Suzie Hwang Pun, Insert Therapeutics, Pasadena, CA, and Mark E. Davis, California Institute of Technology, Pasadena, CA, USA

B. Biodegradable Polymers
Gene Delivery Using Polyimidazoles and Related Polymers; Sharon Wong and David Putnam, Cornell University, Ithaca, NY, USA
Poly(?-amino ester)s for Gene Delivery; David M. Lynn, University of Wisconsin, Madison, WI, and Daniel G. Anderson, Akin Akinc, and Robert Langer, Massachusetts Institute of Technology, Cambridge, MA, USA
Cationic Polyesters as Biodegradable Gene Delivery Carriers; Yong-beom Lim, Yan Lee, and Jong-Sang Park, Seoul National University, Korea
Poly(amidoamine)s for Gene Delivery; Paolo Ferruti and Jacopo Franchini, University of Milan, Italy
Chapter 17. Cationic Polysaccharides for Gene Delivery; Tony Azzam and Abraham J. Domb, The Hebrew University - Hadassah Medical School, Jerusalem, Israel
Chitosan Complexes; Gerrit Borchard and Maytal Bivas-Benita, Leiden University, The Netherlands

NON-CONDENSING POLYMERIC SYSTEMS
Pluronic® Block Copolymers for Non-Viral Gene Delivery; Alexander V. Kabanov and Srikanth Sriadibhatla, University of Nebraska Medical Center, Omaha, NE, and Valery Yu. Alakhov, Supratek Pharma, Inc., Dorval, Quebec, Canada
Use of Poly(N-vinyl pyrrolidone) with Noncondensed Plasmid DNA Formulations for Gene Therapy and Vaccines; Michael Nicolaou and Mark Newman, Epimmune, Inc., San Diego, CA, Polly Chang, SRI International, Menlo Park, CA, USA
Use of HPMA Copolymers for Gene Delivery; David Oupicky, Wayne State University, Detroit, MI, USA

POLYMERIC NANOSPHERES AND MICROSPHERES
A. Polymeric Nanospheres
Biodegradable Nanoparticles as Gene Expression Vector; Swayam Prabha, Wenxue Ma, and Vinod Labhasetwar, University of Nebraska Medical Center, Omaha, USA
Nanoparticles Made of Poly(lactic acid) and Poly(ethylene oxide) as Carriers
of Plasmid DNA; Noemi Csaba, Celso Perez, Alejandro Sanchez, and Maria Jose Alonso, University of Santiago de Compostela, Spain
Poly(alkylcyanoacrylate) Nanoparticles for Nucleic Acid Delivery; Elias Fattal and Patrick Couvreur, University of Paris-Sud, France
Layer-by-Layer Nanoengineering with Polyelectrolytes for Bioactive Compound Delivery Applications; Dinesh B. Shenoy, Alexei A. Antipov, and Gleb B. Sukhorukov, Max-Planck Institute of Colloids and Interfaces, Potsdam/Golm, Germany
Ex Vivo and In Vivo Adenovirus-Mediated Gene Delivery intro Refractory
Cells via Nanoparticle Hydrogel Formulation; Ales Prokop and Gianluca Carlesso, Vanderbilt University, Nashville, TN, and Jeffrey M. Davidson, Department of Veteran Affairs Medical Center, Nashville, TN, USA
Protein Nanoparticles for Gene Delivery; Goldie Kaul and Mansoor Amiji, Northeastern University, Boston, MA, USA

B. Polymeric Microspheres
Gene Delivery Using Poly(lactide-co-glycolide) Microspheres; Mary Lynne Hedley; Zycos, Inc.; Lexington, MA, USA
Polyanhydride Microspheres for Gene Delivery; Yong S Jong and Camilla A Santos, Spherics Inc., Lincoln, RI, and Edith Mathiowitz, Brown University, Providence, RI, USA
Microspheres Formulated with Native Hyaluronan for Applications in Gene
Therapy; Yang H. Yun and Weiliam Chen, State University of New York at Stony Brook, Stony Brook, NY, USA

SPECIALIZED DELIVERY SYSTEMS
Genetically Engineered Protein-Based Polymers: Potential in Gene Delivery; Zaki Mageed and Hamid Ghandehari, University of Maryland, Baltimore, MD, USA
Glycopolymer Tools for Studying Targeted Non-Viral Gene Delivery; Kevin G. Rice, Je-Seon Kim, and Dijie Liu, University of Iowa, Iowa City, USA
Targeted Gene Delivery via the Folate Receptor; Shih-Jiuan Chiu and Robert J. Lee, Ohio State University, Columbus, USA
Transferrin Receptor-Targeted Gene Delivery Systems; Ralf Kircheis, Igeneon Immunotherapy of Cancer, Vienna, Austria, and Ernst Wagner, Pharmaceutical Biology/Biotechnology, Ludwig-Maximilians University, Munich, Germany
Gene Delivery to the Lungs; Berma M. Kinsey, Charles L. Densmore, and Frank M. Orson, Baylor College of Medicine, Houston, TX, USA
Cutaneous Gene Delivery; James C. Birchall, Cardiff University, Wales, UK
Enhancement of Wound Repair by Sustained Gene Transfer via Hyaluronan
Matrices; Angela Kim, Daniel M. Checkla, Don Wen, Philip Dehazya, and Weiliam Chen1, Clear Solutions Biotech, Inc., Stony Brook, NY, and 1State University of New York at Stony Brook, NY, USA
Gene Delivery from Tissue Engineering Matrices; Zain Bengali, Christopher B. Rives, and Lonnie D. Shea, Northwestern University, Evanston, IL, USA
Gene Therapy Stents for Instent Restenosis; Ilia Fishbein, Itay Perlstein, and Robert Levy, University of Pennsylvania Medical Center and Children's
Hospital of Philadelphia, PA USA
Gene Delivery Using BioMEMS; Krishnendu Roy, University of Texas, Austin, USA

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Reviews

"…this excellent book was a pleasure to read and a must for anybody interested in polymers…I highly recommend it …to everybody in the research area polymetric and colloidal drug delivery…"
European Journal of Pharmaceutics and Biopharmaceutics, 2005