Polymers in Drug Delivery: 1st Edition (Hardback) book cover

Polymers in Drug Delivery

1st Edition

Edited by Ijeoma F. Uchegbu, Andreas G. Schatzlein

CRC Press

280 pages | 78 B/W Illus.

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pub: 2006-05-19
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Description

Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we’ve seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene therapy.

While Polymers in Drug Delivery offers much new insight for the veteran specialist, this work has been compiled with the non-specialist in mind. It includes contributions from many of the world’s leading drug delivery specialists, yet avoids jargon and presents background information that initiates the next generation of scientists into the amazing work going on at the frontiers of this rapidly evolving science.

Targeting specific issues at the forefront of drug delivery today, this engaging volume—

· Outlines the issues that must be considered when selecting a polymer for fabricating a drug delivery agent or other medical devices

· Explains the more commonly used methods by which polymers may be characterized prior to use

· Profiles polymer matrices that have been used in the formulation of solid oral dosage forms, drug delivery scaffolds, and hydrogels

· Examines the issues surrounding the encapsulation of biologics within microspheres

· Explores the use of nanoparticulates, especially solid nanoparticles and nanocapsules prepared from largely-water-insoluble cyanoacrylate polymers

· Discusses polymeric micelles and investigates the potential of soluble polymer prodrugs and polymer nanomedicines

· Details the contribution made by polymers and dendrimers to the gene delivery effort, which may one day lead to effective treatments for  largely incurable diseases 

Noting a dramatic paradigm shift that is bridging the gap between materials science and life science, the editors have compiled this volume to paint an interdisciplinary portrait of drug delivery that will challenge young scientists to turn their attention and effort towards this critical branch of biomedicine. Containing state-of-the-art information for drug delivery scientists, it is also a great choice for medical and  pharmaceutical students and others seeking an in-depth introduction to the field.

Reviews

“… explains the role of polymers in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. It contains 13 chapters, which cover different aspects of polymers in drug delivery. … The book is ideally suited for medical and pharmaceutical scientists and students. ”

— John F. Kennedy, Zaheera Parveen, Chembiotech Laboratories, Institute of Research and Development, University of Birmingham Research Park, UK, in International Journal of Biological Macromolecules, Vol. 41, 2007

Table of Contents

Introduction; Ijeoma F. Uchegbu

Selecting the Right Polymer for Biomaterial Applications; Allan S. Hoffman

Polymer Characterization Techniques; Wei Wang

The Role of Polymers in Solid Oral Dosage Forms; Richard A. Kendall and Abdul W. Basit

Hydrogel Drug Delivery Systems; Seong Hoon Jeong, Kang Moo Huh, and Kinam Park

An Assessment of the Role of Polymers for Drug Delivery in Tissue Engineering; Patrick J. Ginty, Steven M. Howdle, Felicity R.A.J. Rose, and Kevin M. Shakesheff

Poly (lactic-co-glycolic acid) Microspheres; Camille Bouissou and Chris van der Walle

Polymeric Nanoparticles as Drug Carriers; Patrick Couvreur and Hervé Hillaireau

Polymeric Micelles as Pharmaceutical Carriers; Vladimir P. Torchilin

Polymeric Vesicles; Ijeoma Florence Uchegbu, Shona Anderson, and Anthony Brownlie

Polymer–Drug Conjugates; Vaikunth Cuchelkar and Jindrich Kopeek

Polymers Used for the Delivery of Genes in Gene Therapy; Pei Lee Kan, Andreas G. Schätzlein, and Ijeoma F. Uchegbu

Dendrimers in Drug and Gene Delivery; Christine Dufès, Ijeoma F. Uchegbu, and Andreas G. Schätzlein

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
MED071000
MEDICAL / Pharmacology
TEC021000
TECHNOLOGY & ENGINEERING / Material Science