Polymers in Medicine: Biomedical and Pharmaceutical Applications, 1st Edition (Hardback) book cover

Polymers in Medicine

Biomedical and Pharmaceutical Applications, 1st Edition

By Emo Chiellini, Raphael M. Ottenbrite

CRC Press

272 pages

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Hardback: 9780877629290
pub: 1992-06-13
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Description

The utilization of polymers in medicine has become a reality in the last decade. This book is a concise presentation of the fundamentals, applications, and methods of optimization of polymeric drugs and polymeric drug delivery systems for medicinal purposes. The basic rationale for the use of polymeric drugs and polymer delivery systems is the possibility to alter the pharmacokinetics and pharmacodynamics of therapeutic agents so as to maintain an adequate therapeutic environment at the site of disfunction for an extended period of time.

The primary objectives for using polymeric drugs and polymeric drug delivery systems are to introduce new and efficient methods of drug administration, to improve efficacy and patient compliance, to decrease toxicity, and to ensure safety. The following factors influence the design and performance of polymers for medicinal applications: disease, drug properties, type of therapy (acute or chronic), physiology of the patient, administration route, and the site requiring therapy.

Table of Contents

Microencapsulation of Mammalian Cells in Biocompatible Polyacrylate: A Progress Report

M. Sefton and others, Dept. of Chemical Engineering and Applied Chemistry, Center for Biomaterials, University of Toronto

Methacrylic Polymers Obtained by Radiation Induced Polymerization for the Slow Release of Peptide and Protein Drugs

F. M. Veronese and others, Dept. of Pharmaceutical Science, CNR, University of Padova; S. Lora and M. Carenza, Institute of High Energy Photochemistry and Radiation, CNR (Italy)

Poly(ethylene oxide) (PEO) Constant Release Monolithic Devices

Apicella and others, Dept. of Materials and Production Engineering, University of Naples; B. Capello, Dept. of Pharmaceutical and Toxologic Chemistry, University of Naples; M. La Rotonda, Dept. of Pharmaceutical and Toxologic Chemistry, University of Cagliari

Versions of Immobilized Poly(ethylene oxide) for Medical Applications

E. W. Merrill and others, MIT; R. W. Pekala, Lawrence Livermore Laboratory; K. A. Dennison, 3M Corp.; S-W. Tay, St. Jude Memorial Corp.; C. Sung, NIH; E. Chaikof, Massachusetts General Hospital; P. Rempp and P. Lutz, Institute C. Sadron (France); A. D. Callow and others, New England Medical Center, Tufts University Medical School

Potentiators of Prostaglandin Antiaggregatory Action on Platelets: Some Studies of Phosphodiesterase Inhibition and Platelet Membrane Penetration

H. Bamford, I. P. Middleton and K. G. Al-Lamee, The Institute of Medical and Dental Bioengineering, University of Liverpool

Wound Dressings Made of N-Carboxybutyl Chitosan

Riccardo Muzzarelli, Institute of Biochemistry; Graziella Biagini, Institute of Anatomy; Aldo Bertani, Clinic of Plastic Surgery, University of Ancona

Drug Release from Hydrocortisone Esters of Hyaluronic Acid: Influence of Ester Hydrolysis Rate on Release Rate

L. Goei and others, Dept. of Pharmaceutical Chemistry, University of Kansas; L. Benedetti and others, Advanced Technology Div., FIDIA Research Laboratories

Polymeric Prodrugs: Recent Experience with Devices Formed from Steroid Esters of Hyaluronic Acid

L. Goei and others, Dept. of Pharmaceutical Chemistry, University of Kansas; L. Benedetti and others, Advanced Technology Div., FIDIA Research Laboratories

Development and In Vitro Evaluation of an Oral Formulation for Monosialoganglioside GM1

L. Polato and others, Advanced Technology Div., FIDIA SpA

Drug-Polymer Systems Based on Semisynthetic Hydrogels

S. Dumitriu and M. Dumitriu, Polytechnic Institute of Jassy; D. Dumitriu, Institute of Medicine and Pharmacy; Cristina Medvichi, University of Jassy, Centre for Biological Researches (Romania)

Synthesis and Pharmacological Action of Some Cholestyramin Analogs

Mihia Nechifor and others, Institute of Medicine and Pharmacy; Marieta Nichifor and others, ``Petru Poni'' Institute of Macromolecular Chemistry (Romania)

Muramyl Dipeptide Polymer Conjugates

T. M. Turk, S. Webb and R. M. Ottenbrite, Departments of Biology and Chemistry, Virginia Commonwealth University

Antitumor and Antiviral Activities of Certain Polyoxometalates

Toshihiro Yamase and Kazufumi Tomita, Research Laboratory of Resources Utilization, Tokyo Institute of Technology; Yoshiko Seto and Haruhisa Fujita, Div. of Chemotherapy, Pharmaceutical Institute, Keio University (Japan)

Selective In Vitro Tumor Localization of Chlorine 6 and Its Related Derivatives; A Preliminary and Comparative Biochemical Study of Biodistribution and Photosensitization

Mohamed El-Far, Biochemistry Div., Mansoura University (Egypt)

Promising Applications of Lovastatin for Combatting Photosensitivity Side Effects Caused by Polymeric Hematoporphyrin Derivative: A Novel Therapeutic Approach

Mohamed El-Far, Biochemistry Div., Mansoura University; M. Ghoneim, Urology and Nephrology Center, Mansoura University (Egypt)

Lipopeptide Based Biomaterials for Cosmetology and Dermatology

Bernard R. Gallot, Laboratoire des Materiaux Organiques, CNRS (France)

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
TEC021000
TECHNOLOGY & ENGINEERING / Material Science