Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell function. The discovery of this cellular interaction has led to an abundance of scientific, medical, and commercial applications with unlimited potential.
Pore-forming Peptides and Protein Toxins describes how natural and synthetic peptides and toxins form pores and ionic channels that cause cell membrane collapse and cell death. Divided into two parts on pore-forming proteins and pore-forming peptides, each chapter reviews the normal physiological cellular structure and function, discusses the interference of toxins with this process, and considers the use of specific toxins in research. Written by researchers from around the world, the text includes such topics as the channel-forming properties of Helicobacter pylori and the role of amyloid peptide channels in the development of amyloid diseases.
This authoritative volume provides a multidisciplinary approach to understanding the basic principles and cellular mechanisms of the action of toxins and their potential use as research tools. It is an essential work for researchers and students in the fields of biochemistry, toxicology, biophysics, and pharmaceutical science.
PART 1 PORE-FORMING PROTEINS
Staphylococcal Bicomponent Leucotoxins, Mechanisms of Action, Impact on Cells and Contribution to Virulence, Gilles Prévost, Gianfranco Menestrina, Didier A. Colin, Sandra Werner, Stephen Bronner, Mauro Dalla Serra, Lamin Baba Moussa, Manual Coraiola, Alain Gravet, and Henri Monteil
The Formulation of Ion-permeable Channels by RTX-toxins in Lipid Bilayer Membranes: Basis for Their Biological Activity, Roland Benz
Properties of the Monomeric and the Pentameric Pseudomonas Cytotoxin, Annette Sliwinski-Korell, Takako Nakada, Dietmar Linder, Monica Linder, Sabine Geis, Marita Langewische, and Freider Lutz
Helicobacter pylori Vacuolating Toxin VacA: Channel-forming Properties and Cell Intoxication, Mario Zoratti, Francesco Tombola, Cesare Montecucco, Locantonio Debellis, and Emanuelle Papini
Delta-endotoxin Mode of Action, Doron Gerber and Yechiel Shai
Functional Studies of Helix a-5 Region from Bacillus Thuringiensis Cryl1Ab d-endotoxin, Mario Soberón, Rigoberto V. Pérez, María E. Nuñez-Valdez, Isabel Gómez, Jorge Sánchez, Leopoldo Güereca, and Alejandra Bravo
Colicin Channels and Protein Translocation: Parallels with Diphtheria Toxin,Stephen L. Slatin and Paul Kienker
Actinoporins, Pore-forming Toxins of Sea Anemones (Actiniaria), Gregor Anderluh and Peter Macek
PART 2 PORE-FORMING PEPTIDES
Structural and Change Requirements for Antimicrobial Peptide Insertion into Biological and Model Membranes, Hong Xia Zhoa, Andrea C. Rinaldi, Anna Rufo, Argante Bozzi, Paavo K. Kinnunen, and Antonio Di Giulio
Pardaxins - Pore-forming Neurotoxins as Pharmaceutical Tools in Dissecting Neurotransmitter Exocytosis and Neurotoxicity, Philip Lazarovici
Cecropin-melittin Hybrid Peptides as Versatile Templates in the Development of Membrane-active Antibiotic Agents, Luis Rivas and David Andreu
The Syringomycins: Lipodepsipeptide Pore Formers from Plant Bacterium Pseudomonas syringae, Jon Y. Takemoto, Joseph G. Brand, Yuri A. Kaulin, Valery V. Malev, Ludmila V. Schagina, and Katalin Blasko
Molecular Mechanisms of Action of Syringopeptins, Antifungal Peptides from Pseudomonas syringae pv. syringae, Mauro Dalla Serra, Gianfranco Menestrina, Armando Carpaneto, Franco Gambale, Vincenzo Fogliano, and Alessandro Ballio
The Role of Amyloid Peptide Channels in Amyloid Disease, Yutaka Hirakura, Rustam Azimova, Meng-Chin Lin, and Bruce L. Kagan