Preclinical and Clinical Modulation of Anticancer Drugs: 1st Edition (Hardback) book cover

Preclinical and Clinical Modulation of Anticancer Drugs

1st Edition

By Kenneth D. Tew, Peter J. Houghton, Janet A. Houghton

CRC Press

384 pages

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Hardback: 9780849372919
pub: 1993-09-15
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Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.

Table of Contents

Introduction to the Concept of Modulation. Modulation of Glutathione. Radioprotectors and Radiosensitizers as Modulating Agents. Modulation of the "Mer Phenotype." Modulation of P-Glycoprotein-Mediated Multidrug Resistance. Modulation of 5-Fluorouracil. Miscellaneous Modulators.

About the Series

Handbooks in Pharmacology and Toxicology

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
MEDICAL / Pharmacology