Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.
Introduction to the Concept of Modulation. Modulation of Glutathione. Radioprotectors and Radiosensitizers as Modulating Agents. Modulation of the "Mer Phenotype." Modulation of P-Glycoprotein-Mediated Multidrug Resistance. Modulation of 5-Fluorouracil. Miscellaneous Modulators.