Introduces the principles that augment the formulation of products free from traditional preservatives by creating a hostile environment for microorganisms without diminishing quality. The text emphasizes that the preservation of a product should be inherent in the formula and examines the use of multifunctional chemicals whose secondary characteristics include germistatic and germicidal qualities.
Table of Contents
Principles for product preservation; the effect of acid pH on microorganisms and survival strategies that enable microorganisms to grow in products; the effect of water activity on cosmetic and drug preservation; the role of surfactants in self-preserving cosmetic and drug formulas; fatty acids and esters - multifunctional components of product preservative systems; biomimetic phospholipids - components for self-preserving formulae; the role of antioxidants in cosmetic and drug preservation; aroma chemicals as preservatives; chelating agents as preservative potentiators; the role of packaging in product preservation; preservative-free and self-preserving cosmetic and drug products - the future.
"This book describes. . .a unique approach to the formulation of dermatological and cosmetic products and the authors should be congratulated for bringing it to the attention of the interested parties. The book provides a well documented bibliography at the end of each chapter with the most recent references. "
---American Journal of Pharmaceutical Education