First Published in 1979, this book offers a full comprehensive guide to the applications and uses of radiopharmacology. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for radiologists and other practitioners in their respective fields.
PART I: RADIOPHARMACOLOGY TECHNIQUES
1. Introduction. 2. The Training of Radiopharmacologists. 3. Isotopic Labeling with Carbon-14 and Tritium. 4. Nonisotopic Labeling. 5. Tissue Preparation for Liquid Scintillation and Gamma Counting – The Counting Process. 6. Tissue Preparation for Autoradiography – The Autoradiographic Process. 7. Method of Fractioning Subcellar Particles to Determine Intracellular Localization of Radiotracers. 8. Data Analysis in Radiotracer Studies. 9. Use of Computers in Radiotracer Studies.
PART II: RADIOTRACER DESIGN
1. Introduction. 2. Radiotracer Design Using Mathematical Models. 3. Biochemical and Pharmacological Rationales in Radiotracer Design. 4. The Design of Receptor-Binding Radiotracers. Index.
PART III: BASIC RADIOTRACER AND RECEPTOR PROPERTIES
1. Introduction. 2. Molecular Properties of Radiotracer Receptors. 3. Radiotracer Localization by Receptor-Ligand Interactions. 4. Radiolabeled Enzyme Inhibitors for Imaging. 5. Radiotracer Interactions with Sex Steroid Hormone Receptor Proteins (Receptor Mapping). 6. Stimulating and Depressing Radiotracer Metabolism. 7. In Vitro Experiments to Demonstrate Radiotracer Metabolism. 8. In Vivo Measurement of Transport and Metabolic Processes Using Radiotracers. 9. Fate of Radiometabolites. 10. Adverse Reactions to Radiotracers. 11. In Vitro Stability of Radiotracers.
PART IV: BIOLOGICAL TRANSPORT OF RADIOTRACERS
1. Introduction. 2. Structure and Function of Cell Membranes, and Cellular Transport of Drugs. 3. Effect of Transport in Distribution of Radioions and Radiolabeled Metabolites. 4. Effects of Solute Structure in the Transport of Radiotracers. 5. Techniques to Study the Transport of Radiotracers. Index.
PART V: MECHANISMS OF LOCALIZATION OF RADIOTRACERS
1. Introduction. 2. A Kinetic Approach to the Mechanisms of Localization of Radiotracers. 3. Single Compartmental Distribution by Dilution. 4. Multiple Compartmental Localization by Diffusion. 5. Radiotracer Distribution by Active Transport. 6. Function of Muscle Cells and Myocardial Imaging. 7. Study of Renal Cell Function by Radiotracer Fixation. 8. Kidney Secretion and Filtration Studies Using Radiotracers. 9. Thyroid Cell Kinetics Studies Using Radiotracers. 10. Adrenal Uptake and Metabolism of Labeled Phosphorous Compounds in Bone. 11. Study of Hepatocyte Function Using Radiotracers. 12. Assessment of Hepatic Function by ¹⁴CO₂ Breath Analysis. 13. Passive Exchange of Labeled Phosphorous Compounds in Bone. 14. Kinetic Analysis of Bone Imaging Agent. 15. Radiofluoride Kinetics. 16. Mechanisms of Localization of Free Radioions. 17. Mechanism of Localization of Metallic Radioions in Soft Tissue Tumors. 18. The Role of Phagocytosis and Pinocytosis in the Localization of Radiotracers. 19. Trapping of Amino Acids. 20. Radiotracer Techniques to Study Fibrin Deposition and Lysis. 21. Radiation Dose Calculations in Radiotracer Studies. 22. SI Units in Radiopharmacology. Index.
Are there elusive titles that you need and have been trying to source for years but thought that you would never be able to find?
Well this may be the end of your quest – here is a fantastic opportunity for you to discover past brilliance and purchase previously out of print and unavailable titles by some of the world’s most eminent academic scholars.
Drawing from over 100 years of innovative, cutting-edge publishing, Routledge Revivals is an exciting programme whereby key titles from the distinguished and extensive backlist of the many acclaimed imprints associated with Routledge will be re-issued.
The programme draws upon the illustrious backlists of Kegan Paul, Trench & Trubner, Routledge & Kegan Paul, Methuen, Allen & Unwin and Routledge itself.
Routledge Revivals spans the whole of the Humanities and Social Sciences, and includes works by some of the world’s greatest thinkers including Emile Durkheim, Max Weber, Simone Weil, Martin Buber, Karl Jaspers and Max Beloff.
If you are interested in Revivals in the Behavioral Sciences, please visit https://www.routledge.com/series/PSYREVIVALS