600 pages | 225 Color Illus.
This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.
1. Overview of the Mucosal Immune System Structure 2. Phylogeny of the Mucosal Immune System 3. Immunological and Functional Differences among Individual Compartments of the Mucosal Immune System 4. Secreted Effectors of the Innate Mucosal Barrier 5. Immune Function of Epithelial Cells 6. Intraepithelial Lymphocytes: Unusual T Cells at Epithelial Surfaces 7. Lymphocyte Populations within the Lamina Propria 8. Innate Lymphoid Cells in Mucosal Immunobiology 9. Role of T regulatory Cells in Mucosal Immunoregulation 10. Mucosal B cells and Their Function 11. Secretory Immunoglobulins and Their Transport 12. Role of Dendritic Cells in Integrating Immune Responses to Lumenal Antigens 13. Intestinal Macrophages in Defense of the Mucosa 14. Mucosal Basophils, Mast Cells and Eosinophils 15. M Cells and the Follicle-Associated Epithelium 16. Lymphocyte Trafficking from Inductive Sites to Effector Sites 17. Mucosal Tolerance 18. Recognition of Microbe-Associated Molecular Patterns by Pattern Recognition Receptors 19. The Commensal Microbiota and Its Relationship to Homeostasis and Disease 20. The Immune System of the Genitourinary Tract 21. Mucosal Immune Responses to Microbes in the Genital Tract 22. The Nasopharyngeal and Oral Immune System 23. Bronchus-associated Lymphoid Tissue and Immune-mediated Respiratory Diseases 24. The Ocular Surface as a Mucosal Immune Site 25. Mucosal Interactions with Enteropathogenic Bacteria 26. Helicobacter pylori Infection 27. Mucosal Responses to Helminth Infections 28. Viral infections 29. Infection-driven Periodontal Disease 30. Principles of Mucosal Vaccine Strategies 31. Celiac Disease 32. IgA Nephropathy 33. Mucosal Manifestations of Immunodeficiencies 34. Inflammatory Bowel Disease 35. Food Sensitive and Eosinophilic Enteropathies