In recent years, research into prions has progressed at an impressive pace. In this book internationally renowned experts provide an up-to-date description of the great advances made in our understanding of prions and prion diseases. This volume provides a comprehensive overview of the pathogenesis, molecular biology, biochemistry, cellular biology, animal biology, animal models and immunology. This book is essential to all researchers working in this highly topical field and is recommended reading for scientists in other areas of biology and medicine.
Table of Contents
1. Peripheral Pathogenesis of Prion Diseases. 2. The Prion Protein in Cell Culture. 3. A Functional Role for a Copper Binding Prion Protein. 4. Binding and Conversion Reactions Between Prion Protein Isoforms. 5. Cellular Control of Prion Formation and propagation in Yeast. 6. Targeting the Murine PrP Gene. 7. PrP Deletion Mutants. 8. Transgenic Mouse Models of Prion Disease. 9. Prnd and the Doppel Protein. 10. Immunological Advances in Prion Diseases.
The quality of the science is high...a useful stepping-stone and should be read as such by those working in this field. - Microbiology Today, Vol. 31, November 2004
Prions and Prion Diseases: Current Perspectives provides an excellent summary of scientific methods and progerss associated with this unusual ethological agent. The book is highly recommended for those researchers examining prion-associated diseases and to scientists interested in learning more about prions and unusual fatal brain diseases. - SIM News, July/August, 2005